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View Structure Prediction Details

Protein: FBpp0297513, Rpn6-PB
Organism: Drosophila melanogaster
Length: 422 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0297513, Rpn6-PB.

Description E-value Query
Range
Subject
Range
gi|91090690 - gi|91090690|ref|XP_974687.1| PREDICTED: similar to CG10149-PA, isoform A [Tribolium castaneum]
259.0 [0..1] [422..214]

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Predicted Domain #1
Region A:
Residues: [1-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGATLFERA QALSSVNREE QDSSLLNKLV RDQEGAENDE ERIRIKEQGI LQQGELYKQE  60
   61 GKAKELADLI KVTRPFLSSI SKAKAAKLVR SLVDMFLDMD AGTGIEVQLC KDCIEWAKQE 120
  121 KRTFLRQSLE ARLIALYFDT ALYTEALALG AQLLRELKKL DDKNLLVEVQ LLESKTYHAL 180
  181 SNLPKARAAL TSARTTANAI YCPPKVQGAL DLQSGILHAA DERDFKTAFS YFYEAFEGFD 240
  241 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.0
Match: 2fo7A
Description: Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [241-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVDSVKALTS LKYMLLCKIM LGQSDDVNQL VSGKLAITYS GRDIDAMKSV AEASHKRSLA  60
   61 DFQA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [305-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALKEYKKELA EDVIVQAHLG TLYDTMLEQN LCRIIEPYSR VQVAHVAESI QLPMPQVEKK  60
   61 LSQMILDKKF SGILDQGEGV LIVFEETPVD KTYERVLETI QSMGKVVDTL YQKAKKLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.522879
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.50995556050336 bayes_pls_golite062009
nucleic acid binding 3.38144578566524 bayes_pls_golite062009
binding 3.33026160538031 bayes_pls_golite062009
DNA binding 3.30822066787723 bayes_pls_golite062009
transcription factor activity 2.60537570879007 bayes_pls_golite062009
hydrolase activity 2.30467124306022 bayes_pls_golite062009
structural constituent of ribosome 1.46680509390433 bayes_pls_golite062009
sequence-specific DNA binding 1.32971938164691 bayes_pls_golite062009
transcription activator activity 1.08566311616647 bayes_pls_golite062009
transcription repressor activity 0.95491822926452 bayes_pls_golite062009
protein binding 0.653872239015235 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.42135864069093 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
small conjugating protein ligase activity 0.118016217031359 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle