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View Structure Prediction Details

Protein: cg-PC
Organism: Drosophila melanogaster
Length: 629 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cg-PC.

Description E-value Query
Range
Subject
Range
gi|76651068 - gi|76651068|ref|XP_887912.1| PREDICTED: similar to zinc finger protein 192 isoform 5 [Bos taurus]
812.0 [0..1] [628..337]

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Predicted Domain #1
Region A:
Residues: [1-119]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYLLSTDGS LAVQKDVKGL TAGGKNNVVR RMFVVNDPSF PPGTQRVITA GGASTVVKKQ  60
   61 DNNQQVLSLD KNCDILPGIS VQVQKVIQGL EDNEDSQGEA PNLKLEPGTL ELSPKTELQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [120-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESMHFSETDA TIKKERPYSC DECGKSFLLK HHLTTHARVH TGERPHICTH CGKSFAHKHC  60
   61 LNTHLLLHST ERPYQCQECK KSFTLKHHLL THSRVHSRER PFVCQECGRA FPLKRHLVTH 120
  121 SKFHAGERPY VCEECGESFA QENHLIMHSR FHGSLNPFVC AECGASFPRK FQLVNHGRIH 180
  181 GKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.30103
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [303-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHSCTVCGKE FLQKRTLVSH MRRVHTGEQA HPCVSCGEGF LTKAELHQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.56
Match: 2dlqA
Description: No description for 2dlqA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.47951889934838 bayes_pls_golite062009
nucleic acid binding 4.35187767955595 bayes_pls_golite062009
DNA binding 4.31051339571017 bayes_pls_golite062009
transcription factor activity 3.28758716579796 bayes_pls_golite062009
transcription repressor activity 3.07956158665183 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.96255357208943 bayes_pls_golite062009
transcription activator activity 1.97757778483124 bayes_pls_golite062009
chromatin binding 1.91511881662436 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.35857850481346 bayes_pls_golite062009
structure-specific DNA binding 1.33097016250582 bayes_pls_golite062009
sequence-specific DNA binding 1.26862497534835 bayes_pls_golite062009
transcription factor binding 1.23738346570539 bayes_pls_golite062009
transcription corepressor activity 1.16887811832337 bayes_pls_golite062009
double-stranded DNA binding 1.00239065862819 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
transcription cofactor activity 0.627794176881836 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [351-459]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVRTAHNGVN PNTSSATIIA NQQLQQAHHH QAGQQTHPQT ITVVSNPGNS TLLTVSTTDA  60
   61 NGVARPQFVC RECGSAFNSR EALALHLRLH TGDKSLMTDL CALTAALPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1g2dC
Description: TATA box-binding zinc finger, TATAZF
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [460-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HFLSTASLNP GTVVTANPNL VGQSPVPVQI ISSTGQVMSQ TTLVQAANST HPQAVVTAVP  60
   61 TMPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [524-629]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGQQQHLQHV AQQQQQQQQQ QQQQQQHVVS VAPANKPKSH FCASCGKGFA AKHGLMQHNR  60
   61 RHPNGGCTVR THVCECGKAF FQKNHLMLHQ RQHLETKPAI SQQQVC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.09691
Match: 1x6hA
Description: Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle