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View Structure Prediction Details

Protein: cg-PC
Organism: Drosophila melanogaster
Length: 629 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cg-PC.

Description E-value Query
Range
Subject
Range
gi|76651068 - gi|76651068|ref|XP_887912.1| PREDICTED: similar to zinc finger protein 192 isoform 5 [Bos taurus]
812.0 [0..1] [628..337]

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Predicted Domain #1
Region A:
Residues: [1-119]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYLLSTDGS LAVQKDVKGL TAGGKNNVVR RMFVVNDPSF PPGTQRVITA GGASTVVKKQ  60
   61 DNNQQVLSLD KNCDILPGIS VQVQKVIQGL EDNEDSQGEA PNLKLEPGTL ELSPKTELQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [120-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESMHFSETDA TIKKERPYSC DECGKSFLLK HHLTTHARVH TGERPHICTH CGKSFAHKHC  60
   61 LNTHLLLHST ERPYQCQECK KSFTLKHHLL THSRVHSRER PFVCQECGRA FPLKRHLVTH 120
  121 SKFHAGERPY VCEECGESFA QENHLIMHSR FHGSLNPFVC AECGASFPRK FQLVNHGRIH 180
  181 GKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.30103
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [303-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHSCTVCGKE FLQKRTLVSH MRRVHTGEQA HPCVSCGEGF LTKAELHQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.56
Match: 2dlqA
Description: No description for 2dlqA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.47951889934838 bayes_pls_golite062009
nucleic acid binding 4.35187767955595 bayes_pls_golite062009
DNA binding 4.31051339571017 bayes_pls_golite062009
transcription factor activity 3.28758716579796 bayes_pls_golite062009
transcription repressor activity 3.07956158665183 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.96255357208943 bayes_pls_golite062009
transcription activator activity 1.97757778483124 bayes_pls_golite062009
chromatin binding 1.91511881662436 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.35857850481346 bayes_pls_golite062009
structure-specific DNA binding 1.33097016250582 bayes_pls_golite062009
sequence-specific DNA binding 1.26862497534835 bayes_pls_golite062009
transcription factor binding 1.23738346570539 bayes_pls_golite062009
transcription corepressor activity 1.16887811832337 bayes_pls_golite062009
double-stranded DNA binding 1.00239065862819 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
transcription cofactor activity 0.627794176881836 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [351-459]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVRTAHNGVN PNTSSATIIA NQQLQQAHHH QAGQQTHPQT ITVVSNPGNS TLLTVSTTDA  60
   61 NGVARPQFVC RECGSAFNSR EALALHLRLH TGDKSLMTDL CALTAALPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1g2dC
Description: TATA box-binding zinc finger, TATAZF
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [460-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HFLSTASLNP GTVVTANPNL VGQSPVPVQI ISSTGQVMSQ TTLVQAANST HPQAVVTAVP  60
   61 TMPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [524-629]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGQQQHLQHV AQQQQQQQQQ QQQQQQHVVS VAPANKPKSH FCASCGKGFA AKHGLMQHNR  60
   61 RHPNGGCTVR THVCECGKAF FQKNHLMLHQ RQHLETKPAI SQQQVC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.09691
Match: 1x6hA
Description: Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle