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View Structure Prediction Details

Protein: cid-PA
Organism: Drosophila melanogaster
Length: 225 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cid-PA.

Description E-value Query
Range
Subject
Range
gi|32345668 - gi|32345668|gb|AAM80988.1| centromeric histone H3-like protein Cid [Drosophila melanogaster]
253.0 [0..1] [225..1]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRHSRAKRA PRPSANNSKS PNDDDTAFRS PEPEDGTDYG LEFTTSQLTL QDNNRRSSTL  60
   61 RRDAGRRQPA ARDSSTSGEE EDQENRY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTTRSPQTRR MTVQQESKTR AAGPVAAQNQ TRRRKAANPM SRAKRMDREI RRLQHHPGTL  60
   61 IPKLPFSRLV REFIVKYSDD EPLRVTEGAL LAMQESCEMY LTQRLADSYM LTKHRNRVTL 120
  121 EVRDMALMAY ICDRGRQF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.045757
Match: 1u35A
Description: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.77402874003635 bayes_pls_golite062009
binding 3.12722734218139 bayes_pls_golite062009
centromeric DNA binding 2.60445660474495 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.17470289921427 bayes_pls_golite062009
DNA binding 1.81202026929492 bayes_pls_golite062009
nucleic acid binding 1.77431079461635 bayes_pls_golite062009
transcription factor binding 1.49909125565453 bayes_pls_golite062009
transcription cofactor activity 1.37016786211811 bayes_pls_golite062009
protein binding 1.2861218811362 bayes_pls_golite062009
transcription regulator activity 1.07001118921201 bayes_pls_golite062009
transcription coactivator activity 0.483720456107869 bayes_pls_golite062009
transcription repressor activity 0.38665562690801 bayes_pls_golite062009
histone acetyltransferase activity 0.322861678821436 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.322861678821436 bayes_pls_golite062009
histone binding 0.218942897869955 bayes_pls_golite062009
transcription corepressor activity 0.0581806902793005 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle