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View Structure Prediction Details

Protein: CG8594-PA
Organism: Drosophila melanogaster
Length: 813 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG8594-PA.

Description E-value Query
Range
Subject
Range
CLCN3_RABIT - H(+)/Cl(-) exchange transporter 3 OS=Oryctolagus cuniculus GN=CLCN3 PE=2 SV=3
CLCN3 - chloride channel 3
gi|114596820, gi... - gi|114596820|ref|XP_001153970.1| PREDICTED: chloride channel 3 isoform 5 [Pan troglodytes], gi|11459...
444.0 [0..31] [812..3]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDRKALITL DGESSAEDDP IILQKEAGPT SKAVQDFGLH QREEPSTSAL ARRATLSGNN  60
   61 HLLDDSQPLL MGNNSVPPDI PINGSAGSPN RNINSSEPIF HLRSRTAAAS TPNYESLDYE 120
  121 VCE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [124-638]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTLFQDEQRK RLTERFSLRK DIIRWIIFIQ IGIITALIAC TIDIIIEELS IRKYTFLYNS  60
   61 VKENVPLSDA SDRDLLIPYL YWLLFSIVPV AFGAAMVTYI EPITAGSGIP QVKSYLNGVK 120
  121 IPRIVRIKTL AVKAIGVITS VVGGLAGGKE GPMIHAGAVV AAGISQGKST TFLKDFRIFK 180
  181 AFRDDHEKRD FVLGGGAAGV SAAFGAPIGG MLFSLEEAAS FWNQNLIWRT LVASIISVFT 240
  241 LNIVLSAYHG LNDFTFTGLF NLGKFDTPLK FDYFELPIFM ILGVTGGLLG AAWNSLNTKI 300
  301 NKFRKRFIPW KIGKVLEAVV VAMMGVTLAC LMIYFINDCR PLGNDPTNNP VQLFCEDNEY 360
  361 NAVAALWFQT PEATVRSLFH DPPGSHKILT LALFTVVYYV LSCATFGLNV SLGVFIPTAL 420
  421 VGAAWGRLLA MLTYYVFPQA EFLHPGKYAL IGAAANLGGV LRMTISLSVI LMETTGVETS 480
  481 FFFPLIIALI SAKWVGDYFN EGIYDTQIQV NHVPM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.39794
Match: 1kplA
Description: Clc chloride channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
anion channel activity 6.77290758049983 bayes_pls_golite062009
chloride channel activity 6.77290758049983 bayes_pls_golite062009
anion transmembrane transporter activity 6.08111514985329 bayes_pls_golite062009
voltage-gated chloride channel activity 5.99544422864122 bayes_pls_golite062009
voltage-gated anion channel activity 5.99544422864122 bayes_pls_golite062009
ion transmembrane transporter activity 5.07840957725271 bayes_pls_golite062009
ion channel activity 4.93164650815682 bayes_pls_golite062009
substrate-specific channel activity 4.81149777353187 bayes_pls_golite062009
channel activity 4.78965126968592 bayes_pls_golite062009
passive transmembrane transporter activity 4.78965126968592 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.67227438984104 bayes_pls_golite062009
voltage-gated ion channel activity 4.27956097534048 bayes_pls_golite062009
voltage-gated channel activity 4.255638017629 bayes_pls_golite062009
gated channel activity 4.1072949331811 bayes_pls_golite062009
transporter activity 2.94995161862691 bayes_pls_golite062009
transmembrane transporter activity 2.84443650880263 bayes_pls_golite062009
substrate-specific transporter activity 2.82470397063503 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [639-813]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTWEPLPQYK GLKAREILSK PVICIKIRDS ANYIYEMLKK CDHNGFPVVD DVCGDRRSEG  60
   61 RVCGIILRSQ LIVILLKSLY VENKRFWLPE TSIQTFRDLY PRFPSIKSVR KLDEKINYTV 120
  121 DLSMFMNPSP IRVNPHDSVP RIFQIFRALG LRHLLVINHE NRIAGIITRR DFIYK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1zfjA
Description: Inosine monophosphate dehydrogenase (IMPDH); Type II inosine monophosphate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
anion channel activity 4.72273788503492 bayes_pls_golite062009
chloride channel activity 4.72273788503492 bayes_pls_golite062009
ion transmembrane transporter activity 4.33792188010109 bayes_pls_golite062009
anion transmembrane transporter activity 4.07884311796555 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.93353180499293 bayes_pls_golite062009
voltage-gated chloride channel activity 3.88653297495834 bayes_pls_golite062009
voltage-gated anion channel activity 3.88653297495834 bayes_pls_golite062009
metal ion transmembrane transporter activity 3.3574064637316 bayes_pls_golite062009
cation transmembrane transporter activity 3.18351510675711 bayes_pls_golite062009
ion channel activity 2.96289511581809 bayes_pls_golite062009
substrate-specific channel activity 2.85393728592978 bayes_pls_golite062009
channel activity 2.83666655624333 bayes_pls_golite062009
passive transmembrane transporter activity 2.83666655624333 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.73643550405923 bayes_pls_golite062009
voltage-gated ion channel activity 2.26198818630559 bayes_pls_golite062009
voltage-gated channel activity 2.23919445086891 bayes_pls_golite062009
transporter activity 2.21524357108065 bayes_pls_golite062009
gated channel activity 2.18781915118831 bayes_pls_golite062009
transmembrane transporter activity 2.10896266379801 bayes_pls_golite062009
substrate-specific transporter activity 2.087339200694 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 1.81809447487679 bayes_pls_golite062009
binding 1.44413793636898 bayes_pls_golite062009
magnesium ion transmembrane transporter activity 1.02459848653197 bayes_pls_golite062009
protein binding 0.5290109527055 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle