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View Structure Prediction Details

Protein: FSHB_RAT
Organism: Rattus norvegicus
Length: 130 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FSHB_RAT.

Description E-value Query
Range
Subject
Range
FSHB_MOUSE - Follitropin subunit beta OS=Mus musculus GN=Fshb PE=2 SV=1
189.0 [0..1] [130..1]
FSHB_MASCO - Follitropin subunit beta OS=Mastomys coucha GN=FSHB PE=2 SV=1
188.0 [0..1] [130..1]
gi|89274058 - gi|89274058|dbj|BAE80738.1| follicle stimulating hormone beta-subunit precursor protein [Phodopus su...
188.0 [0..2] [130..1]
gi|81295283 - gi|81295283|dbj|BAE48271.1| follicle stimulating hormone beta-subunit precursor protein [Mesocricetu...
188.0 [0..2] [130..1]
gi|73948014 - gi|73948014|ref|XP_533624.2| PREDICTED: similar to Lutropin beta chain precursor (Luteinizing hormon...
185.0 [0..11] [126..356]
gi|86439875 - gi|86439875|dbj|BAE78968.1| follicle stimulating hormone beta-subunit precursor protein [Cricetulus ...
185.0 [0..2] [130..1]
FSHB_MERUN - Follitropin subunit beta OS=Meriones unguiculatus GN=FSHB PE=2 SV=1
184.0 [0..2] [130..1]
gi|75992453 - gi|75992453|dbj|BAE45118.1| follicle stimulating hormone beta-subunit precursor protein [Cricetulus ...
184.0 [0..2] [130..1]
gi|108743544 - gi|108743544|dbj|BAE95635.1| follicle stimulating hormone beta-subunit precursor protein [Microtus m...
183.0 [0..2] [130..1]

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Predicted Domain #1
Region A:
Residues: [1-130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKSIQLCIL LWCLRAVCCH SCELTNITIS VEKEECRFCI SINTTWCEGY CYTRDLVYKD  60
   61 PARPNTQKVC TFKELVYETI RLPGCARHSD SLYTYPVATE CHCGKCDSDS TDCTVRGLGP 120
  121 SYCSFGEMKE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1xwdB
Description: Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.98600168355158 bayes_pls_golite062009
receptor serine/threonine kinase binding 4.8369569327215 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 4.69128752159226 bayes_pls_golite062009
transforming growth factor beta receptor binding 4.69128752159226 bayes_pls_golite062009
growth factor activity 4.01406832911234 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 3.35517597922994 bayes_pls_golite062009
cytokine activity 2.90799896011039 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 2.76400237542695 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 2.7562170740679 bayes_pls_golite062009
binding 2.64101807129423 bayes_pls_golite062009
growth factor binding 2.41942870726502 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 2.36823915226245 bayes_pls_golite062009
protein binding 2.36794464190805 bayes_pls_golite062009
cell surface binding 2.33284053060339 bayes_pls_golite062009
glycosaminoglycan binding 1.9734035688309 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.78479767888975 bayes_pls_golite062009
heparin binding 1.73353807509439 bayes_pls_golite062009
pattern binding 1.34327634476459 bayes_pls_golite062009
polysaccharide binding 1.17302952845956 bayes_pls_golite062009
platelet-derived growth factor binding 1.16893591942376 bayes_pls_golite062009
hormone activity 0.94314407550729 bayes_pls_golite062009
SMAD binding 0.918765103972039 bayes_pls_golite062009
collagen binding 0.894753581887191 bayes_pls_golite062009
protein dimerization activity 0.697058311884552 bayes_pls_golite062009
follicle-stimulating hormone activity 0.648906125812902 bayes_pls_golite062009
carbohydrate binding 0.37618196282327 bayes_pls_golite062009
protein homodimerization activity 0.344090347736442 bayes_pls_golite062009
identical protein binding 0.273591586673912 bayes_pls_golite062009
fibronectin binding 0.1110090445978 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.0796166411998893 bayes_pls_golite062009

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