YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|254900172, gi...
Organism:	Listeria monocytogenes J0161
Length:	425 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|254900172, gi....

Description	E-value	Query Range	Subject Range
gi\|241904139, gi... - gi\|241904139\|ref\|ZP_04788848.1\| O-acetylhomoserine/O-acetylserine sulfhydrylase [Thermoanaerobacter ... gi\|76589009, gi\|... - gi\|76795695\|ref\|ZP_00778067.1\| O-acetylhomoserine/O-acetylserine sulfhydrylase [Thermoanaerobacter e...	401.0	[0..1]	[422..1]
gi\|242257839, gi... - gi\|242257839\|ref\|ZP_04802688.1\| O-acetylhomoserine/O-acetylserine sulfhydrylase [Thermoanaerobacter ... gi\|114805914, gi... - gi\|167039628\|ref\|YP_001662613.1\| O-acetylhomoserine/O-acetylserine sulfhydrylase [Thermoanaerobacter...	399.0	[0..1]	[422..1]
gi\|125974346, gi... - gi\|67874928\|ref\|ZP_00504479.1\| O-acetylhomoserine/O-acetylserine sulfhydrylase [Clostridium thermoce...	392.0	[0..1]	[424..1]
gi\|20808539 - gi\|20808539\|ref\|NP_623710.1\| O-acetylhomoserine sulfhydrylase [Thermoanaerobacter tengcongensis MB4] gi\|20517164, gi\|... - gi\|20808539\|ref\|NP_623710.1\| O-acetylhomoserine sulfhydrylase [Thermoanaerobacter tengcongensis MB4]...	391.0	[0..1]	[422..1]
gi\|83573070, gi\|... - gi\|83590156\|ref\|YP_430165.1\| O-acetylhomoserine/O-acetylserine sulfhydrylase [Moorella thermoacetica...	383.0	[0..2]	[424..4]
gi\|56418819, gi\|... - gi\|56418819\|ref\|YP_146137.1\| O-acetylhomoserine aminocarboxypropyltransferase [Geobacillus kaustophi...	383.0	[0..1]	[424..1]
gi\|254824132 - gi\|254824132\|ref\|ZP_05229133.1\| hypothetical protein LmonFS_03150 [Listeria monocytogenes FSL J1-194... gi\|226223224, gi... - gi\|226223224\|ref\|YP_002757331.1\| hypothetical protein Lm4b_00621 [Listeria monocytogenes Clip81459],... gi\|254879508 - gi\|254879508\|ref\|ZP_05252218.1\| hypothetical protein LmonFSL_09939 [Listeria monocytogenes FSL J2-07... gi\|254853207 - gi\|254853207\|ref\|ZP_05242555.1\| hypothetical protein LmonoFSL_07878 [Listeria monocytogenes FSL R2-5... gi\|255521143 - gi\|255521143\|ref\|ZP_05388380.1\| hypothetical protein LmonocFSL_07951 [Listeria monocytogenes FSL J1-... gi\|133727973, gi... - gi\|153165891\|ref\|ZP_01926556.1\| O-acetylhomoserine (thiol)-lyase [Listeria monocytogenes FSL N1-017]... gi\|133736144, gi... - gi\|254932130\|ref\|ZP_05265489.1\| hypothetical protein LmonH_06852 [Listeria monocytogenes HPB2262], g... gi\|46880106, gi\|... - gi\|46906840\|ref\|YP_013229.1\| O-acetylhomoserine (thiol)-lyase [Listeria monocytogenes str. 4b F2365]... gi\|47093336, gi\|... - gi\|47093336\|ref\|ZP_00231105.1\| O-acetylhomoserine (thiol)-lyase [Listeria monocytogenes str. 4b H785... gi\|217334580, gi... - gi\|217965310\|ref\|YP_002350988.1\| O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase ...	381.0	[0..1]	[425..1]
gi\|56962212, gi\|... - gi\|56962212\|ref\|YP_173935.1\| O-acetylhomoserine (thiol)-lyase [Bacillus clausii KSM-K16], gi\|5690844...	379.0	[0..1]	[424..1]
gi\|147676588, gi... - gi\|98660749\|dbj\|GAA02076.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476765...	378.0	[0..1]	[424..1]
gi\|89336386, gi\|... - gi\|89896938\|ref\|YP_520425.1\| hypothetical protein DSY4192 [Desulfitobacterium hafniense Y51], gi\|893...	376.0	[0..1]	[424..2]

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Predicted Domain #1

Region A:
Residues: [1-425]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNEYKFETI QVHGGHTPDG DTHSRAVPIY QTTSYTFDSP EHAAALFGLQ ETGNIYTRIM  60
   61 NPTTAVLEER LTLLEGGIGA VATASGMAAI TYSILNIAGS GDHIVAAATL YGGTHTLFSH 120
  121 TFKTFGIDVT FVDPNEPENF EKAIKDNTKA VFIETIGNPD INIVDIEKVA KIAHASDIPL 180
  181 IVDNTFATAY LNRPFDFGAD IVVYSATKFI GGHGVAIGGA VIDSGKFNWA NGKFPKLVVP 240
  241 DDSYNGLSYT NDVGAAAYIT KLRVSLLRDT GAALSPFNAF LLILGLETLS LRLEQHVKNA 300
  301 KQVANFLNDH PKVAWVNYPG LKDNKYHELA QKYLPKGPGS IFTFGVKGGY EAGKKVIESV 360
  361 ELFSHLANVG DAKSLIIHPA STTHQQLSEE QQLTAGVKPE SIRLSIGIEN ADDIIQDLTK 420
  421 ALEQI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.30103
Match:	2ctzA
Description:	Crystal structure of o-acetyl homoserine sulfhydrylase from Thermus thermophilus HB8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	2.82824364293374	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	2.82824364293374	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	1.87460342369605	bayes_pls_golite062009
transcription regulator activity	1.67701710033155	bayes_pls_golite062009
DNA binding	1.4774443071095	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
nucleic acid binding	1.39741122443159	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
transcription factor activity	1.15775909410582	bayes_pls_golite062009
binding	1.09053123792737	bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity	0.994935084630764	bayes_pls_golite062009
ligase activity	0.827063849687833	bayes_pls_golite062009
carbon-sulfur lyase activity	0.698312655247044	bayes_pls_golite062009
cystathionine beta-lyase activity	0.6849039330512	bayes_pls_golite062009
vitamin binding	0.66463470119531	bayes_pls_golite062009
cystathionine gamma-lyase activity	0.505859361763689	bayes_pls_golite062009
alanine-glyoxylate transaminase activity	0.48682493494502	bayes_pls_golite062009
O-acyltransferase activity	0.452440867878365	bayes_pls_golite062009
cysteine synthase activity	0.417849187928985	bayes_pls_golite062009
structural molecule activity	0.347975812448725	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.271623203801431	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity	0.0669652799570574	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: