YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|126509508, gi...
Organism:	Vibrio cholerae NCTC 8457
Length:	214 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|126509508, gi....

Description	E-value	Query Range	Subject Range
PYRE_VIBCH - Orotate phosphoribosyltransferase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N... gi\|254847045, gi... - gi\|254851340\|ref\|ZP_05240690.1\| orotate phosphoribosyltransferase [Vibrio cholerae MO10], gi\|2548470... PYRE_VIBCH - Orotate phosphoribosyltransferase OS=Vibrio cholerae GN=pyrE PE=1 SV=2	206.0	[0..2]	[214..1]
gi\|75816555 - gi\|75816555\|ref\|ZP_00747022.1\| COG0461: Orotate phosphoribosyltransferase [Vibrio cholerae V52] gi\|75828202 - gi\|75828202\|ref\|ZP_00757637.1\| COG0461: Orotate phosphoribosyltransferase [Vibrio cholerae O395]	204.0	[0..2]	[214..1]
PYRE_PHOLL - Orotate phosphoribosyltransferase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / C... PYRE_PHOLL - Orotate phosphoribosyltransferase OS=Photorhabdus luminescens subsp. laumondii GN=pyrE PE=3 SV=1	202.0	[0..2]	[214..1]
gi\|116220658, gi... - gi\|75819962\|ref\|ZP_00750022.1\| COG0461: Orotate phosphoribosyltransferase [Vibrio cholerae V51], gi\|...	201.0	[0..2]	[214..1]
gi\|89093848, gi\|... - gi\|89093848\|ref\|ZP_01166794.1\| orotate phosphoribosyltransferase [Oceanospirillum sp. MED92], gi\|890...	201.0	[0..2]	[214..1]
PYRE_SHISS - Orotate phosphoribosyltransferase OS=Shigella sonnei (strain Ss046) GN=pyrE PE=3 SV=1	200.0	[0..2]	[214..1]
gi\|85711492, gi\|... - gi\|85711492\|ref\|ZP_01042550.1\| orotate phosphoribosyltransferase [Idiomarina baltica OS145], gi\|8569...	200.0	[0..2]	[214..1]
gi\|30043343, gi\|... - gi\|30065082\|ref\|NP_839253.1\| orotate phosphoribosyltransferase [Shigella flexneri 2a str. 2457T], gi... PYRE_SHIFL - Orotate phosphoribosyltransferase OS=Shigella flexneri GN=pyrE PE=3 SV=4 gi\|56480392, gi\|... - gi\|56480392\|ref\|NP_709421.2\| orotate phosphoribosyltransferase [Shigella flexneri 2a str. 301], gi\|5...	200.0	[0..2]	[214..1]
PYRE_VIBPA - Orotate phosphoribosyltransferase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN... gi\|149748730, gi... - gi\|153837867\|ref\|ZP_01990534.1\| orotate phosphoribosyltransferase [Vibrio parahaemolyticus AQ3810], ... PYRE_VIBPA - Orotate phosphoribosyltransferase OS=Vibrio parahaemolyticus GN=pyrE PE=3 SV=1	199.0	[0..2]	[214..1]
gi\|254038842, gi... - gi\|254038842\|ref\|ZP_04872894.1\| orotate phosphoribosyltransferase [Escherichia sp. 1_1_43], gi\|22683... gi\|227883810, gi... - gi\|227883810\|ref\|ZP_04001615.1\| orotate phosphoribosyltransferase [Escherichia coli 83972], gi\|22783... gi\|26110718, gi\|... - gi\|26250288\|ref\|NP_756328.1\| orotate phosphoribosyltransferase [Escherichia coli CFT073], gi\|2611071... gi\|75514296 - gi\|75514296\|ref\|ZP_00736604.1\| COG0461: Orotate phosphoribosyltransferase [Escherichia coli 53638]	199.0	[0..2]	[214..6]

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Predicted Domain #1

Region A:
Residues: [1-214]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKAYQREFI EFALEKQVLK FGEFTLKSGR KSPYFFNAGL FNTGRDLARL GRFYAAALVD  60
   61 SGIEFDVLFG PAYKGIPIAT TTAVALADHH DVDTPYCFNR KEAKNHGEGG NLVGSKLEGR 120
  121 VMLVDDVITA GTAIRESMEL IQANKADLAG VLVAIDRQEK GKGELSAIQE VERDFGCAVI 180
  181 SIVSLTDLIT YLEQQGNNTE HLEAVKAYRA QYGI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.30103
Match:	1oroA
Description:	Orotate PRTase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
adenine phosphoribosyltransferase activity	3.1748712918814	bayes_pls_golite062009
uracil phosphoribosyltransferase activity	3.0470646511978	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	2.97347277288245	bayes_pls_golite062009
transferase activity	2.73727660668741	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.21367942706564	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	2.02298774328915	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	1.51875493459374	bayes_pls_golite062009
nucleobase binding	1.28671115202467	bayes_pls_golite062009
purine binding	1.24786927434743	bayes_pls_golite062009
amidophosphoribosyltransferase activity	0.932396739123353	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
nucleic acid binding	0.552133387792911	bayes_pls_golite062009
binding	0.535390228935555	bayes_pls_golite062009
DNA binding	0.439741935655503	bayes_pls_golite062009
transcription regulator activity	0.396538943915776	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: