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View Structure Prediction Details

Protein: EMX2_MOUSE
Organism: Mus musculus
Length: 253 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMX2_MOUSE.

Description E-value Query
Range
Subject
Range
gi|16549686 - gi|16549686|dbj|BAB70842.1| unnamed protein product [Homo sapiens]
156.0 [0..1] [253..1]
gi|73998900 - gi|73998900|ref|XP_853333.1| PREDICTED: similar to empty spiracles homolog 2 [Canis familiaris]
gi|157821339, gi... - gi|62642544|ref|XP_574698.1| PREDICTED: similar to empty spiracles homolog 2 [Rattus norvegicus], gi...
tr|G1U020|G1U020... - pep:novel chromosome:oryCun2:18:64946421:64951155:1 gene:ENSOCUG00000012088 transcript:ENSOCUT000000...
EMX2_MOUSE - Homeobox protein EMX2 OS=Mus musculus GN=Emx2 PE=1 SV=3
gi|146327286 - gi|146327286|gb|AAI41563.1| Empty spiracles homolog 2 (Drosophila) [synthetic construct]
155.0 [0..1] [253..1]
EMX2_BOVIN - Homeobox protein EMX2 OS=Bos taurus GN=EMX2 PE=2 SV=1
155.0 [0..1] [253..1]
gi|50749851 - gi|50749851|ref|XP_421783.1| PREDICTED: similar to emx2 homeoprotein [Gallus gallus]
150.0 [0..1] [253..111]
gi|21902138 - gi|21902138|gb|AAM78421.1| Emx2 [Scyliorhinus canicula]
143.0 [0..1] [253..1]
gi|182891742, gi... - gi|65301426|ref|NP_571355.2| empty spiracles homeobox 2 [Danio rerio], gi|62202080|gb|AAH92713.1| Em...
142.0 [0..1] [253..1]
gi|49257830, gi|... - gi|49257830|gb|AAH74130.1| MGC81839 protein [Xenopus laevis], gi|147904461|ref|NP_001086052.1| MGC81...
142.0 [0..1] [253..1]
gi|116294310 - gi|116294310|gb|AAP79287.2| hox 7 [Saccoglossus kowalevskii]
142.0 [0..8] [242..2]

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Predicted Domain #1
Region A:
Residues: [1-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAA  60
   61 GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL PSLHSPHPLF ASQQRDPSTF 120
  121 YPWLIHRYRY LGHRFQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [137-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNDTSPESFL LHNALARKPK RIRTAFSPSQ LLRLEHAFEK NHYVVGAERK QLAHSLSLTE  60
   61 TQVKVWFQNR RTKFKRQKLE EEGSDSQQKK KGTHHINRWR IATKQASPEE IDVTSDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1b8iA
Description: Ultrabithorax (ubx) homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.67711146264366 bayes_pls_golite062009
DNA binding 4.26679916438424 bayes_pls_golite062009
nucleic acid binding 4.10991419309805 bayes_pls_golite062009
transcription factor activity 3.74788993580019 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.16521751467289 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.96364983538233 bayes_pls_golite062009
transcription repressor activity 1.79427849359671 bayes_pls_golite062009
transcription activator activity 1.6126228397074 bayes_pls_golite062009
transcription factor binding 1.32991027110041 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.9526286147364 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
chromatin binding 0.775421813815509 bayes_pls_golite062009
transcription cofactor activity 0.71989890364863 bayes_pls_golite062009
transcription corepressor activity 0.0615820877359203 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle