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View Structure Prediction Details

Protein: EMX2_MOUSE
Organism: Mus musculus
Length: 253 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMX2_MOUSE.

Description E-value Query
Range
Subject
Range
gi|16549686 - gi|16549686|dbj|BAB70842.1| unnamed protein product [Homo sapiens]
156.0 [0..1] [253..1]
gi|73998900 - gi|73998900|ref|XP_853333.1| PREDICTED: similar to empty spiracles homolog 2 [Canis familiaris]
gi|157821339, gi... - gi|62642544|ref|XP_574698.1| PREDICTED: similar to empty spiracles homolog 2 [Rattus norvegicus], gi...
tr|G1U020|G1U020... - pep:novel chromosome:oryCun2:18:64946421:64951155:1 gene:ENSOCUG00000012088 transcript:ENSOCUT000000...
EMX2_MOUSE - Homeobox protein EMX2 OS=Mus musculus GN=Emx2 PE=1 SV=3
gi|146327286 - gi|146327286|gb|AAI41563.1| Empty spiracles homolog 2 (Drosophila) [synthetic construct]
155.0 [0..1] [253..1]
EMX2_BOVIN - Homeobox protein EMX2 OS=Bos taurus GN=EMX2 PE=2 SV=1
155.0 [0..1] [253..1]
gi|50749851 - gi|50749851|ref|XP_421783.1| PREDICTED: similar to emx2 homeoprotein [Gallus gallus]
150.0 [0..1] [253..111]
gi|21902138 - gi|21902138|gb|AAM78421.1| Emx2 [Scyliorhinus canicula]
143.0 [0..1] [253..1]
gi|182891742, gi... - gi|65301426|ref|NP_571355.2| empty spiracles homeobox 2 [Danio rerio], gi|62202080|gb|AAH92713.1| Em...
142.0 [0..1] [253..1]
gi|49257830, gi|... - gi|49257830|gb|AAH74130.1| MGC81839 protein [Xenopus laevis], gi|147904461|ref|NP_001086052.1| MGC81...
142.0 [0..1] [253..1]
gi|116294310 - gi|116294310|gb|AAP79287.2| hox 7 [Saccoglossus kowalevskii]
142.0 [0..8] [242..2]

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Predicted Domain #1
Region A:
Residues: [1-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAA  60
   61 GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL PSLHSPHPLF ASQQRDPSTF 120
  121 YPWLIHRYRY LGHRFQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [137-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNDTSPESFL LHNALARKPK RIRTAFSPSQ LLRLEHAFEK NHYVVGAERK QLAHSLSLTE  60
   61 TQVKVWFQNR RTKFKRQKLE EEGSDSQQKK KGTHHINRWR IATKQASPEE IDVTSDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1b8iA
Description: Ultrabithorax (ubx) homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.67711146264366 bayes_pls_golite062009
DNA binding 4.26679916438424 bayes_pls_golite062009
nucleic acid binding 4.10991419309805 bayes_pls_golite062009
transcription factor activity 3.74788993580019 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.16521751467289 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.96364983538233 bayes_pls_golite062009
transcription repressor activity 1.79427849359671 bayes_pls_golite062009
transcription activator activity 1.6126228397074 bayes_pls_golite062009
transcription factor binding 1.32991027110041 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.9526286147364 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
chromatin binding 0.775421813815509 bayes_pls_golite062009
transcription cofactor activity 0.71989890364863 bayes_pls_golite062009
transcription corepressor activity 0.0615820877359203 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle