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View Structure Prediction Details

Protein: gi|309315, gi|73...
Organism: Mus musculus
Length: 218 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|309315, gi|73....

Description E-value Query
Range
Subject
Range
HPRT_RAT - Hypoxanthine-guanine phosphoribosyltransferase OS=Rattus norvegicus GN=Hprt1 PE=1 SV=1
gi|244376, gi|21... - gi|244376|gb|AAB21288.1| hypoxanthine phosphoribosyltransferase; HPRT [Rattus sp.], gi|2117729|pir||...
187.0 [0..1] [218..1]
gi|109088576 - gi|109088576|ref|XP_001101923.1| PREDICTED: similar to phosphoribosyl transferase domain containing ...
185.0 [0..3] [217..160]
HPRT_CHICK - Hypoxanthine-guanine phosphoribosyltransferase OS=Gallus gallus GN=HPRT1 PE=2 SV=1
184.0 [0..1] [218..1]
gi|61368202, gi|... - gi|61368202|gb|AAX43128.1| hypoxanthine phosphoribosyltransferase 1 [synthetic construct], gi|546955...
184.0 [0..1] [218..1]
gi|47115227 - gi|47115227|emb|CAG28573.1| HPRT1 [Homo sapiens]
183.0 [0..1] [218..1]
gi|67970557 - gi|67970557|dbj|BAE01621.1| unnamed protein product [Macaca fascicularis]
183.0 [0..1] [218..1]
gi|13435621 - gi|13435621|gb|AAH04686.1| Hypoxanthine guanine phosphoribosyl transferase 1 [Mus musculus]
183.0 [0..1] [218..1]
HPRT_PIG - Hypoxanthine-guanine phosphoribosyltransferase OS=Sus scrofa GN=HPRT1 PE=2 SV=3
183.0 [0..1] [218..1]

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Predicted Domain #1
Region A:
Residues: [1-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTRSPSVVI SDDEPGYDLD LFCIPNHYAE DLEKVFIPHG LIMDRTERLA RDVMKEMGGH  60
   61 HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI RLKSYCNDQS TGDIKVIGGD 120
  121 DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV KQYSPKMVKV ASLLVKRTSR SVGYRPDFVG 180
  181 FEIPDKFVVG YALDYNEYFR NLNHVCVISE TGKAKYKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.522879
Match: 1bzyA
Description: Hypoxantine-guanine PRTase (HGPRTase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
adenine phosphoribosyltransferase activity 4.07252508868782 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 3.91023158228049 bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity 3.89356447922614 bayes_pls_golite062009
transferase activity 2.73727660668741 bayes_pls_golite062009
nucleobase binding 2.70671399975507 bayes_pls_golite062009
purine binding 2.63033967717893 bayes_pls_golite062009
transferase activity, transferring pentosyl groups 2.53679639481311 bayes_pls_golite062009
uracil phosphoribosyltransferase activity 2.36237864658341 bayes_pls_golite062009
catalytic activity 2.30431811394775 bayes_pls_golite062009
amidophosphoribosyltransferase activity 1.6596316647688 bayes_pls_golite062009
ribose phosphate diphosphokinase activity 1.51875493459374 bayes_pls_golite062009
protein binding 1.02514711359042 bayes_pls_golite062009
adenine binding 0.817887117933035 bayes_pls_golite062009
diphosphotransferase activity 0.749909396904601 bayes_pls_golite062009
binding 0.644392905117932 bayes_pls_golite062009
nucleic acid binding 0.439453264070391 bayes_pls_golite062009
transcription regulator activity 0.369893745269311 bayes_pls_golite062009
DNA binding 0.275043319532312 bayes_pls_golite062009
orotate phosphoribosyltransferase activity 0.148898393751978 bayes_pls_golite062009

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