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View Structure Prediction Details

Protein: CCS_MOUSE
Organism: Mus musculus
Length: 274 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCS_MOUSE.

Description E-value Query
Range
Subject
Range
CCS - copper chaperone for superoxide dismutase
290.0 [0..1] [274..1]
gi|60830005 - gi|60830005|gb|AAX36906.1| copper chaperone for superoxide dismutase [synthetic construct]
290.0 [0..1] [274..1]
CCS_PIG - Copper chaperone for superoxide dismutase OS=Sus scrofa GN=CCS PE=2 SV=1
286.0 [0..1] [274..1]
gi|57099643 - gi|57099643|ref|XP_533218.1| PREDICTED: similar to Copper chaperone for superoxide dismutase (Supero...
284.0 [0..1] [274..1]
CCS_RAT - Copper chaperone for superoxide dismutase OS=Rattus norvegicus GN=Ccs PE=1 SV=1
281.0 [0..1] [274..1]
gi|109105430 - gi|109105430|ref|XP_001118002.1| PREDICTED: copper chaperone for superoxide dismutase [Macaca mulatt...
268.0 [0..20] [274..1]
gi|47212233 - gi|47212233|emb|CAF96200.1| unnamed protein product [Tetraodon nigroviridis]
250.0 [0..12] [269..7]
gi|52139009, gi|... - gi|58332386|ref|NP_001011020.1| copper chaperone for superoxide dismutase [Xenopus (Silurana) tropic...
246.0 [0..4] [274..3]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASKSGDGGT VCALEFAVQM SCQSCVDAVH KTLKGVAGVQ NVDVQLENQM VLVQTTLPSQ  60
   61 EVQALLESTG RQAVLKGMGS SQLQNLGAAV A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.522879
Match: 2crlA
Description: The apo form of HMA domain of copper chaperone for superoxide dismutase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [92-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILEGCGSIQG VVRFLQLSSE LCLIEGTIDG LEPGLHGLHV HQYGDLTRDC NSCGDHFNPD  60
   61 GASHGGPQDT DRHRGDLGNV RAEAGGRATF RIEDKQLKVW DVIGRSLVID EGEDDLGRGG 120
  121 HPLSKITGNS GKRLACGIIA RSAGLFQNPK QICSCDGLTI WEERGRPIAG QGRKDSAQPP 180
  181 AHL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1do5A
Description: Copper chaperone for superoxide dismutase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein phosphatase 2B binding 13.5719110466797 bayes_pls_golite062009
superoxide dismutase activity 12.1093323949609 bayes_pls_golite062009
oxidoreductase activity, acting on superoxide radicals as acceptor 12.1093323949609 bayes_pls_golite062009
superoxide dismutase copper chaperone activity 5.30724557593005 bayes_pls_golite062009
chaperone binding 5.11696266714142 bayes_pls_golite062009
copper ion binding 4.51765925795625 bayes_pls_golite062009
copper chaperone activity 3.53752588768671 bayes_pls_golite062009
protein phosphatase binding 3.26481550276071 bayes_pls_golite062009
phosphatase binding 3.1414149853516 bayes_pls_golite062009
metallochaperone activity 2.82622922333955 bayes_pls_golite062009
copper ion transmembrane transporter activity 2.53311528765098 bayes_pls_golite062009
ion transmembrane transporter activity 2.46331862428318 bayes_pls_golite062009
transition metal ion binding 2.451533032488 bayes_pls_golite062009
cation transmembrane transporter activity 2.41954384727602 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.30916666149383 bayes_pls_golite062009
binding 2.28211284921339 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.0278666635337 bayes_pls_golite062009
protein binding 1.96660745768497 bayes_pls_golite062009
enzyme binding 1.82618630359051 bayes_pls_golite062009
metal ion binding 1.79413011653575 bayes_pls_golite062009
cation binding 1.79413011653575 bayes_pls_golite062009
ion binding 1.78699219376941 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.64083855886256 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 1.63756992236587 bayes_pls_golite062009
transporter activity 1.33910763967058 bayes_pls_golite062009
transmembrane transporter activity 1.12504351752996 bayes_pls_golite062009
catalytic activity 1.09233965765942 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.704985452118462 bayes_pls_golite062009
substrate-specific transporter activity 0.618042428454534 bayes_pls_golite062009
zinc ion binding 0.25600715352161 bayes_pls_golite062009
antioxidant activity 0.240491838042064 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle