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View Structure Prediction Details

Protein: SYJ1_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 1076 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYJ1_SCHPO.

Description E-value Query
Range
Subject
Range
SYNJ2_MOUSE - Synaptojanin-2 OS=Mus musculus GN=Synj2 PE=1 SV=2
971.0 [0..1] [1072..7]
INP52 - Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI...
INP52_YEAST - Polyphosphatidylinositol phosphatase INP52 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
969.0 [0..1] [1075..1]
gi|44984180, gi|... - gi|45198293|ref|NP_985322.1| AFL228Wp [Ashbya gossypii ATCC 10895], gi|44984180|gb|AAS53146.1| AFL22...
gi|44984180 - gi|44984180|gb|AAS53146.1| AFL228Wp [Ashbya gossypii ATCC 10895]
964.0 [0..1] [1046..1]
gi|38104181, gi|... - gi|39945134|ref|XP_362104.1| hypothetical protein MGG_04549 [Magnaporthe grisea 70-15], gb|EAA50790....
962.0 [0..2] [1062..48]
gi|16647984 - gi|16647984|gb|AAK61722.1| synaptojanin 2B1 [Rattus norvegicus]
960.0 [0..1] [1072..7]
gi|46108722, gi|... - gi|46108722|ref|XP_381419.1| hypothetical protein FG01243.1 [Gibberella zeae PH-1], gi|42545261|gb|E...
951.0 [0..3] [1014..21]

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Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQCLLREKPR SLALVNKDHA LMFHSVPQNK NSLSVCVAEF TALSEKPLEG FRKISSHRIY  60
   61 GTLGLIELEG SNFLCVISGA SEVARVRDKE RVFRIMEVCF YSVNRSNWDH IRQENYSPDI 120
  121 PDGYDTDTQG YDSYK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [136-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YAAEPFSSLR KLLTNGSFYF SLDFDITTRL QLRTSQTMTE PQYDSMHTQF MWNEFMLRQL  60
   61 IKFRSHLNGD EKSALDGCRF FTCAIRGFAS TEQFKLGIQT IRLSLISRLS SLRAGTRFLS 120
  121 RGVDDDGNVA NFVETETILD SSKYCVSYCQ VRGSIPIFWE QEGVQMFGQK IDITRSLEAT 180
  181 RAAFEKHFTS LIEEYGPVHI INLLGTGSGE RSLSERLRQH IQLSPEKDLI HLTEFDYHSQ 240
  241 IR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [378-529]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFEDANKIRP MIYSDAETFG FYFENNEGQS IVVQDGVFRT NCLDCLDRTN VIQNLVSRVF  60
   61 LEQVMIYTRQ NAGYDFWQVH STIWANNGDA LARIYTGTGA LKSSFTRKGK LSIAGALNDL 120
  121 SKSVGRMYIN NFQDKGRQET IDLLLGRLID QH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.930 0.012 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore

Predicted Domain #4
Region A:
Residues: [530-885]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVILYDPIHE YVNHELRKRE NEFSEHKNVK IFVASYNLNG CSATTKLENW LFPENTPLAD  60
   61 IYVVGFQEIV QLTPQQVISA DPAKRREWES CVKRLLNGKC TSGPGYVQLR SGQLVGTALM 120
  121 IFCKESCLPS IKNVEGTVKK TGLGGVSGNK GAVAIRFDYE DTGLCFITSH LAAGYTNYDE 180
  181 RDHDYRTIAS GLRFRRGRSI FNHDYVVWFG DFNYRISLTY EEVVPCIAQG KLSYLFEYDQ 240
  241 LNKQMLTGKV FPFFSELPIT FPPTYKFDIG TDIYDTSDKH RVPAWTDRIL YRGELVPHSY 300
  301 QSVPLYYSDH RPIYATYEAN IVKVDREKKK ILFEELYNQR KQEVRDASQT SYTLID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 112.0
Match: 1i9yA
Description: Synaptojanin, IPP5C domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 6.16986356176974 bayes_pls_golite062009
phosphatase activity 5.90350467872925 bayes_pls_golite062009
phosphoric ester hydrolase activity 5.84927924311254 bayes_pls_golite062009
phosphatidylinositol bisphosphate phosphatase activity 5.76202422677892 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5.57319461575586 bayes_pls_golite062009
phosphoinositide 5-phosphatase activity 5.57319461575586 bayes_pls_golite062009
inositol-polyphosphate 5-phosphatase activity 4.20215185632047 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 3.88924621938812 bayes_pls_golite062009
lipid phosphatase activity 3.07322777760243 bayes_pls_golite062009
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity 2.64934277728302 bayes_pls_golite062009
phosphatidylinositol-4-phosphate phosphatase activity 2.64934277728302 bayes_pls_golite062009
inositol trisphosphate phosphatase activity 2.32855198081691 bayes_pls_golite062009
phosphatidylinositol-3-phosphatase activity 1.98439062808392 bayes_pls_golite062009
hydrolase activity 1.94088348434922 bayes_pls_golite062009
catalytic activity 1.76511376991978 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 1.43486520454637 bayes_pls_golite062009
binding 1.10604548818653 bayes_pls_golite062009
nucleic acid binding 1.10196417513158 bayes_pls_golite062009
DNA binding 1.08923919229723 bayes_pls_golite062009
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity 0.938520838175434 bayes_pls_golite062009
transcription regulator activity 0.934018277503377 bayes_pls_golite062009
deoxyribonuclease activity 0.620825895803427 bayes_pls_golite062009
nuclease activity 0.531982382500929 bayes_pls_golite062009
protein binding 0.476649214025345 bayes_pls_golite062009
exonuclease activity 0.219613338022829 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.213742479001316 bayes_pls_golite062009
phosphoric diester hydrolase activity 0.137101173922861 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [886-1076]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAGSVAGKPN LIPHLPANGV DKIKQPSSER SKWWFDDGLP AKSIAAPPGP EYRLNPSRPI  60
   61 NPFEPTAEPD WISNTKQSFD KKSSLIDSIP ALSPAPSSLA RSSVSSQRSS TSIIPIKPNK 120
  121 PTKPDHLVAP RVKPLLPPRS GSSSSGVPAP NLTPVNVPPT PPPRKSSASQ RSGDLLASSP 180
  181 EESSISWKPL V

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.11
Match: 2j63A
Description: No description for 2j63A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle