YRC Public Data Repository - Protein Structure Prediction

Protein:	HLDE_YERPN
Organism:	Yersinia pestis Nepal516
Length:	476 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HLDE_YERPN.

Description	E-value	Query Range	Subject Range
gi\|53732809 - gi\|53732809\|ref\|ZP_00155099.2\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran...	2.0E-95	[1..472]	[1..472]
HLDE_HAEIN - Bifunctional protein hldE OS=Haemophilus influenzae GN=hldE PE=3 SV=1 HLDE_HAEIN - Bifunctional protein HldE OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=h...	4.0E-95	[1..472]	[1..472]
HLDE_HAEI8 - Bifunctional protein HldE OS=Haemophilus influenzae (strain 86-028NP) GN=hldE PE=3 SV=1 HLDE_HAEIE - Bifunctional protein HldE OS=Haemophilus influenzae (strain PittEE) GN=hldE PE=3 SV=1 gi\|145269265, gi... - gi\|145637579\|ref\|ZP_01793236.1\| ADP-heptose synthase [Haemophilus influenzae PittHH], gi\|145269265\|g... gi\|145632917, gi... - gi\|145632917\|ref\|ZP_01788650.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr...	5.0E-95	[1..472]	[1..472]
gi\|42631637 - gi\|42631637\|ref\|ZP_00157175.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|145272041, gi... - gi\|145639069\|ref\|ZP_01794677.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr...	1.0E-94	[1..472]	[1..472]
HLDE_ACTPL - Bifunctional protein HldE OS=Actinobacillus pleuropneumoniae GN=hldE PE=3 SV=1	3.0E-94	[1..475]	[1..475]
gi\|126207886, gi... - gi\|126207886\|ref\|YP_001053111.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenylt... gi\|32034719 - gi\|32034719\|ref\|ZP_00134850.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran...	4.0E-94	[1..475]	[2..476]
HLDE_ACTSZ - Bifunctional protein HldE OS=Actinobacillus succinogenes (strain ATCC 55618 / 130Z) GN=hldE PE=3 SV=...	2.0E-93	[1..473]	[1..473]
HLDE_MANSM - Bifunctional protein HldE OS=Mannheimia succiniciproducens (strain MBEL55E) GN=hldE PE=3 SV=1	1.0E-92	[1..473]	[1..473]
gi\|32028852, gi\|... - gi\|32028852\|ref\|ZP_00131970.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran...	2.0E-92	[1..473]	[1..473]
HLDE_ECO24 - Bifunctional protein HldE OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=hldE PE=3 SV=1 gi\|194426262, gi... - gi\|75212315\|ref\|ZP_00712339.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|190901150, gi... - gi\|75227962\|ref\|ZP_00714657.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|192959254, gi... - gi\|75239377\|ref\|ZP_00723348.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|194436680, gi... - gi\|83587510\|ref\|ZP_00926137.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... HLDE_ECOL5 - Bifunctional protein HldE OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=hldE PE=3 SV=1 HLDE_ECOSE - Bifunctional protein HldE OS=Escherichia coli (strain SE11) GN=hldE PE=3 SV=1 HLDE_ECOSM - Bifunctional protein HldE OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=hldE PE=3 SV=1 HLDE_ECO8A - Bifunctional protein HldE OS=Escherichia coli O8 (strain IAI1) GN=hldE PE=3 SV=1 HLDE_ECO27 - Bifunctional protein HldE OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hldE PE=3 SV=1 HLDE_ECO7I - Bifunctional protein HldE OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=hldE PE=3 SV=1 HLDE_ECO55 - Bifunctional protein HldE OS=Escherichia coli (strain 55989 / EAEC) GN=hldE PE=3 SV=1 HLDE_ECOLI - Bifunctional protein hldE [Includes: D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.-) (D-beta-D-hept... gi\|124526037, gi... - gi\|124526037\|ref\|ZP_01698042.1\| rfaE bifunctional protein [Escherichia coli B], gi\|124502141\|gb\|EAY4... sp\|B7UIW0\|HLDE_ECO27 - Bifunctional protein hldE OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hldE PE=3 SV=1 HLDE_ECOBW - Bifunctional protein HldE OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=hldE PE=3 SV=1 gi\|251786329, gi... - gi\|251786329\|ref\|YP_003000633.1\| hypothetical protein B21_02872 [Escherichia coli BL21], gi\|24237860... gi\|253979056, gi... - gi\|254289749\|ref\|YP_003055497.1\| fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransfer... gi\|254038219, gi... - gi\|254038219\|ref\|ZP_04872277.1\| hldE [Escherichia sp. 1_1_43], gi\|226839843\|gb\|EEH71864.1\| hldE [Esc... gi\|254162999, gi... - gi\|254162999\|ref\|YP_003046107.1\| fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransfer... HLDE_ECODH - Bifunctional protein HldE OS=Escherichia coli (strain K12 / DH10B) GN=hldE PE=3 SV=1 HLDE_ECOLC - Bifunctional protein HldE OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=hldE PE=3 SV... gi\|192932382, gi... - gi\|75259985\|ref\|ZP_00731263.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... EG13416 - heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase / Heptose 7-P kinase /heptose 1-... gi\|188491309, gi... - gi\|75511264\|ref\|ZP_00733962.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|89109822, gi\|... - gi\|89109822\|ref\|AP_003602.1\| fused heptose 7-phosphate kinase and heptose 1-phosphate adenyltransfer... EG13416 - heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase / Heptose 7-P kinase /heptose 1-...	3.0E-92	[1..475]	[1..475]

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Predicted Domain #1

Region A:
Residues: [1-317]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVTLPDFRR AGVLVVGDVM LDRYWYGPTC RISPEAPVPV VKVDTIEERP GGAANVAMNI  60
   61 ASLGAVARLV GLTGIDDAAR ALICKLSEVR VRCDFVSVPT HPTITKLRVL SRNQQLIRLD 120
  121 FEEGFDGVDP TPIFERIQLA LPQIGALVLS DYAKGALNSV QPMIQLARKA NVPVLIDPKG 180
  181 SDFERYRGAT LLTPNLSEFE AVVGRCKNEE ELVNRGMQLV ADFELSALLV TRSEQGMTLL 240
  241 QLGKPPLHLP TQAKEVFDVT GAGDTVIGVL AAALAAGNSL EESCFLANAA AGVVVGKLGT 300
  301 STVSPIELEN AIRGRAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.154902
Match:	1gqtA
Description:	Ribokinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribokinase activity	4.25786236481087	bayes_pls_golite062009
catalytic activity	2.11518580948187	bayes_pls_golite062009
carbohydrate kinase activity	1.99025603598964	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.69918601153494	bayes_pls_golite062009
transferase activity	1.65599843675995	bayes_pls_golite062009
kinase activity	1.6060752218324	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.143446029424335	bayes_pls_golite062009
phosphofructokinase activity	0.0784945911925501	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [318-476]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGFGVMDEQQ LKIAVAQARQ RGEKVVMTNG IFDILHAGHV SYLANARKLG DRLIVAVNSD  60
   61 ASTKRLKGEK RPVNPLEQRM VVLGALEAVD WVVPFEEDTP QRLIADILPD LLVKGGDYKP 120
  121 HEIAGSEEVW AAGGEVKVLN FEDGVSTTNI IQSIKNGRG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.69897
Match:	1cozA
Description:	CTP:glycerol-3-phosphate cytidylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.74718220535323	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	2.59548305938725	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	2.59548305938725	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	2.58249040683736	bayes_pls_golite062009
ligase activity	2.24624957842862	bayes_pls_golite062009
acid-amino acid ligase activity	0.12185374712018	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: