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View Structure Prediction Details

Protein: ASCL3_MOUSE
Organism: Mus musculus
Length: 174 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASCL3_MOUSE.

Description E-value Query
Range
Subject
Range
gi|34859995 - gi|34859995|ref|XP_344948.1| PREDICTED: similar to Achaete-scute homolog 3 (bHLH transcriptional reg...
140.0 [0..1] [174..1]
gi|109107347 - gi|109107347|ref|XP_001102401.1| PREDICTED: similar to ASCL3 [Macaca mulatta]
123.0 [0..1] [164..2]
gi|18249655 - gi|18249655|dbj|BAB83913.1| putative bHLH transcription factor [Homo sapiens]
122.0 [0..1] [164..1]
gi|114636046 - gi|114636046|ref|XP_522303.2| PREDICTED: similar to putative bHLH transcription factor [Pan troglody...
122.0 [0..1] [164..2]
MYF6_BOVIN - Myogenic factor 6 OS=Bos taurus GN=MYF6 PE=2 SV=1
109.0 [0..11] [172..16]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTRSYPSPP DRLSVFAESA HLPLSRPFYL DPMVTVHLCP ETPVPASYTD ELPLLPFSSD  60
   61 TLIMNNYGDP YPFPFPMPYT NYR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [84-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RCDYTYGPAF IRKRNERERQ RVKCVNEGYA RLRRHLPEDY LEKRLSKVET LRAAIKYISY  60
   61 LQSLLYPDES ETKKNPRTAS CGSLDPALRV I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.09691
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
promoter binding 1.56457725225443 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription coactivator activity 1.39260472877067 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
structure-specific DNA binding 0.3655541712365 bayes_pls_golite062009
double-stranded DNA binding 0.29436315000437 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle