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View Structure Prediction Details

Protein: ASCL3_MOUSE
Organism: Mus musculus
Length: 174 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASCL3_MOUSE.

Description E-value Query
Range
Subject
Range
gi|34859995 - gi|34859995|ref|XP_344948.1| PREDICTED: similar to Achaete-scute homolog 3 (bHLH transcriptional reg...
140.0 [0..1] [174..1]
gi|109107347 - gi|109107347|ref|XP_001102401.1| PREDICTED: similar to ASCL3 [Macaca mulatta]
123.0 [0..1] [164..2]
gi|18249655 - gi|18249655|dbj|BAB83913.1| putative bHLH transcription factor [Homo sapiens]
122.0 [0..1] [164..1]
gi|114636046 - gi|114636046|ref|XP_522303.2| PREDICTED: similar to putative bHLH transcription factor [Pan troglody...
122.0 [0..1] [164..2]
MYF6_BOVIN - Myogenic factor 6 OS=Bos taurus GN=MYF6 PE=2 SV=1
109.0 [0..11] [172..16]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTRSYPSPP DRLSVFAESA HLPLSRPFYL DPMVTVHLCP ETPVPASYTD ELPLLPFSSD  60
   61 TLIMNNYGDP YPFPFPMPYT NYR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.216 d.129.1 TATA-box binding protein-like
View Download 0.237 d.58.1 4Fe-4S ferredoxins
View Download 0.238 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.492 a.60.8 HRDC-like
View Download 0.271 a.36.1 Signal peptide-binding domain

Predicted Domain #2
Region A:
Residues: [84-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RCDYTYGPAF IRKRNERERQ RVKCVNEGYA RLRRHLPEDY LEKRLSKVET LRAAIKYISY  60
   61 LQSLLYPDES ETKKNPRTAS CGSLDPALRV I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.09691
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
promoter binding 1.56457725225443 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription coactivator activity 1.39260472877067 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
structure-specific DNA binding 0.3655541712365 bayes_pls_golite062009
double-stranded DNA binding 0.29436315000437 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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