YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: Dscam-PK
Organism: Drosophila melanogaster
Length: 701 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PK.

Description E-value Query
Range
Subject
Range
Dscam-PN - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
607.0 [0..1] [701..1]

Back

Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVSQH Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.154902
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [142-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEDIHKAFVI RGNSAILKCD IPSFVADFVN VISWHSDEKE NFYPGTEYDG KYLVLPSGEL  60
   61 HIREVGPEDG YKSYQCRTKH RLTGETRLSA TKGRLVITEP VGSVSPQLSG N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.221849
Match: 1f3rB
Description: Immunoglobulin light chain kappa variable domain, VL-kappa; Immunoglobulin heavy chain variable domain, VH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
antigen binding 4.06466268219034 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
receptor activity 2.6260148704617 bayes_pls_golite062009
transmembrane receptor activity 2.26083981067854 bayes_pls_golite062009
molecular transducer activity 2.26075587783872 bayes_pls_golite062009
signal transducer activity 2.26075587783872 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
peptide antigen binding 1.32632044811608 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.24415316737453 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
myosin light chain kinase activity 0.87238163212 bayes_pls_golite062009
receptor binding 0.838643016003073 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
IgG binding 0.68435857661103 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
protein kinase activity 0.589015157128768 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
G-protein coupled receptor activity 0.51084773288725 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.5037774536831 bayes_pls_golite062009
olfactory receptor activity 0.44769371137055 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.300034766861208 bayes_pls_golite062009
protein complex binding 0.24709070548365 bayes_pls_golite062009
kinase activity 0.232190923918901 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.182775558017364 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
protein serine/threonine kinase activity 0.026512949804781 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.00722693352608417 bayes_pls_golite062009
structural molecule activity 0.00139730528977644 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [253-620]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNQEHITLTR VPKMGSVTLM CPAQAYPVPF FRWYKFIEGT TRKQAVVLND RVKQVSGTLI  60
   61 IKDAVVEDSG KYLCVVNNSV GGESVETVLT VTAPLSAKID PPTQTVDFGR PAVFTCQYTG 120
  121 NPIKTVSWMK DGKAIGHSEP VLRIESVKKE DKGMYQCFVR NDQESAEASA ELKLGGRFDP 180
  181 PVIRQAFQEE TMEPGPSVFL KCVAGGNPTP EISWELDGKK IANNDRYQVG QYVTVNGDVV 240
  241 SYLNITSVHA NDGGLYKCIA KSKVGVAEHS AKLNVYGLPY IRQMEKKAIV AGETLIVTCP 300
  301 VAGYPIDSIV WERDNRALPI NRKQKVFPNG TLIIENVERN SDQATYTCVA KNQEGYSARG 360
  361 SLEVQVMV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.154902
Match: 1mcoH
Description: Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma; Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma; Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.38949638288343 bayes_pls_golite062009
alpha-actinin binding 5.53326178500376 bayes_pls_golite062009
actinin binding 5.48624955510658 bayes_pls_golite062009
structural constituent of muscle 4.78053264661873 bayes_pls_golite062009
antigen binding 3.60138508313109 bayes_pls_golite062009
binding 3.05950525762784 bayes_pls_golite062009
receptor activity 2.40849844553572 bayes_pls_golite062009
molecular transducer activity 2.11593100581996 bayes_pls_golite062009
signal transducer activity 2.11593100581996 bayes_pls_golite062009
transmembrane receptor activity 2.05813971124837 bayes_pls_golite062009
cytoskeletal protein binding 1.54995469932689 bayes_pls_golite062009
actin binding 1.40773197641911 bayes_pls_golite062009
nucleic acid binding 1.33341865156235 bayes_pls_golite062009
DNA binding 1.20391708320115 bayes_pls_golite062009
transcription regulator activity 1.19332924581774 bayes_pls_golite062009
protein binding 1.10840622828945 bayes_pls_golite062009
peptide antigen binding 0.972620809539712 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.917911781808094 bayes_pls_golite062009
receptor binding 0.766394469651557 bayes_pls_golite062009
myosin light chain kinase activity 0.727812088393571 bayes_pls_golite062009
actin filament binding 0.684482417673051 bayes_pls_golite062009
protein kinase activity 0.605125585768526 bayes_pls_golite062009
transcription factor activity 0.554724181253623 bayes_pls_golite062009
myosin heavy chain binding 0.543143020355849 bayes_pls_golite062009
G-protein coupled receptor activity 0.485782264748744 bayes_pls_golite062009
titin binding 0.395513709080215 bayes_pls_golite062009
IgG binding 0.33386837457402 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.328985661202282 bayes_pls_golite062009
kinase activity 0.268573733052192 bayes_pls_golite062009
olfactory receptor activity 0.232427547336012 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.232191642090185 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.229394368927229 bayes_pls_golite062009
protein complex binding 0.0847341919733864 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0426518119496661 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [621-701]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPQIVPFAYE DLINMGDSID LFCQIQKGDR PIKVHWSFER SAGDYGFDQV QPQMRTNRIS  60
   61 EKTSMISIPS ASPAHTGRIP V

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.93
Match: 1nctA
Description: TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.38949638288343 bayes_pls_golite062009
alpha-actinin binding 5.53326178500376 bayes_pls_golite062009
actinin binding 5.48624955510658 bayes_pls_golite062009
structural constituent of muscle 4.78053264661873 bayes_pls_golite062009
antigen binding 3.60138508313109 bayes_pls_golite062009
binding 3.05950525762784 bayes_pls_golite062009
receptor activity 2.40849844553572 bayes_pls_golite062009
molecular transducer activity 2.11593100581996 bayes_pls_golite062009
signal transducer activity 2.11593100581996 bayes_pls_golite062009
transmembrane receptor activity 2.05813971124837 bayes_pls_golite062009
cytoskeletal protein binding 1.54995469932689 bayes_pls_golite062009
actin binding 1.40773197641911 bayes_pls_golite062009
nucleic acid binding 1.33341865156235 bayes_pls_golite062009
DNA binding 1.20391708320115 bayes_pls_golite062009
transcription regulator activity 1.19332924581774 bayes_pls_golite062009
protein binding 1.10840622828945 bayes_pls_golite062009
peptide antigen binding 0.972620809539712 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.917911781808094 bayes_pls_golite062009
receptor binding 0.766394469651557 bayes_pls_golite062009
myosin light chain kinase activity 0.727812088393571 bayes_pls_golite062009
actin filament binding 0.684482417673051 bayes_pls_golite062009
protein kinase activity 0.605125585768526 bayes_pls_golite062009
transcription factor activity 0.554724181253623 bayes_pls_golite062009
myosin heavy chain binding 0.543143020355849 bayes_pls_golite062009
G-protein coupled receptor activity 0.485782264748744 bayes_pls_golite062009
titin binding 0.395513709080215 bayes_pls_golite062009
IgG binding 0.33386837457402 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.328985661202282 bayes_pls_golite062009
kinase activity 0.268573733052192 bayes_pls_golite062009
olfactory receptor activity 0.232427547336012 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.232191642090185 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.229394368927229 bayes_pls_golite062009
protein complex binding 0.0847341919733864 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0426518119496661 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle