YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: Dscam-PAG
Organism: Drosophila melanogaster
Length: 2032 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PAG.

Description E-value Query
Range		 Subject
Range
Dscam-PAO - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
 1506.0 [0..3] [2032..3]

Back

Predicted Domain #1
Region A:
Residues: [1-152] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF YGADILMEYV IR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.0
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [153-242] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNAAVLKCSI PSFVADFVRV ESWIDEEGTE LRPSENYDGK YLVLPSGELH IREVGPEDGY  60
   61 KSYQCRTKHR LTGETRLSAT KGRLVITEPV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 2ig2H
Description: Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
olfactory receptor activity 4.21057154107121 bayes_pls_golite062009
antigen binding 4.06466268219034 bayes_pls_golite062009
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
peptide antigen binding 2.94721224577771 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.83860944503193 bayes_pls_golite062009
growth factor binding 2.28613301180608 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
extracellular matrix structural constituent 1.97667893885412 bayes_pls_golite062009
IgG binding 1.92633562075074 bayes_pls_golite062009
receptor binding 1.70260377709721 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.52958974617075 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.30657787244536 bayes_pls_golite062009
fibroblast growth factor binding 1.27793818082552 bayes_pls_golite062009
fibroblast growth factor receptor activity 1.24730237107473 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
collagen binding 0.635057461053063 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
myosin heavy chain binding 0.49788128784685 bayes_pls_golite062009
cytokine receptor activity 0.34165331857492 bayes_pls_golite062009
protein tyrosine kinase activity 0.318890055375093 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [243-910] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAKAPTFSLE YKLIEVQKSK GTAFALLCQA QAFPVPIIRW YKFIEGTTRK QAVVLNDRVK  60
   61 QVSGTLIIKD AVVEDSGKYL CVVNNSVGGE SVETVLTVTA PLSAKIDPPT QTVDFGRPAV 120
  121 FTCQYTGNPI KTVSWMKDGK AIGHSEPVLR IESVKKEDKG MYQCFVRNDQ ESAEASAELK 180
  181 LGGRFDPPVI RQAFQEETME PGPSVFLKCV AGGNPTPEIS WELDGKKIAN NDRYQVGQYV 240
  241 TVNGDVVSYL NITSVHANDG GLYKCIAKSK VGVAEHSAKL NVYGLPYIRQ MEKKAIVAGE 300
  301 TLIVTCPVAG YPIDSIVWER DNRALPINRK QKVFPNGTLI IENVERNSDQ ATYTCVAKNQ 360
  361 EGYSARGSLE VQVMVAPKIA PFDFGDEPSN FGESASVQCL VTSGDFPVSF AWLFNGREIN 420
  421 ENVYDVSMVK LGKKISALSI DIVRDHHAGN YTCVAVNRAT SVNFTAELVV NVPPRWILEP 480
  481 TDKAFAQGSD AKVECKADGF PKPQVTWKKA VGDTPGEYKD LKKSDNIRVE EGTLHVDNIQ 540
  541 KTNEGYYLCE AINGIGSGLS AVIMISVQAP PEFTEKLRNQ TARRGEPAVL QCEAKGEKPI 600
  601 GILWNMNNMR LDPKNDNRYT IREEILSTGV MSSLSIKRTE RSDSALFTCV ATNAFGSDDA 660
  661 SINMIVQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.221849
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [911-996] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEMPYALKV LDKSGRSVQL SWAQPYDGNS PLDRYIIEFK RSRASWSEID RVIVPGHTTE  60
   61 AQVQKLSPAT TYNIRIVAEN AIGTSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #5
Region A:
Residues: [997-1114] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSEAVTIITA EEAPSGKPQN IKVEPVNQTT MRVTWKPPPR TEWNGEILGY YVGYKLSNTN  60
   61 SSYVFETINF ITEEGKEHNL ELQNLRVYTQ YSVVIQAFNK IGAGPLSEEE KQFTAEGT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.39794
Match: 2edxA
Description: No description for 2edxA was found.

Predicted Domain #6
Region A:
Residues: [1115-1214] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSQPPSDTAC TTLTSQTIRV GWVSPPLESA NGVIKTYKVV YAPSDEWYDE TKRHYKKTAS  60
   61 SDTVLHGLKK YTNYTMQVLA TTAGGDGVRS VPIHCQTEPD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1qg3A
Description: Integin beta-4 subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1215-1672] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEAPTDVKA LVMGNAAILV SWRPPAQPNG IITQYTVYSK AEGAETETKT QKVPHYQMSF  60
   61 EATELEKNKP YEFWVTASTT IGEGQQSKSI VAMPSDQVPA KIASFDDTFT ATFKEDAKMP 120
  121 CLAVGAPQPE ITWKIKGVEF SANDRMRVLP DGSLLIKSVN RQDAGDYSCH AENSIAKDSI 180
  181 THKLIVLAPP QSPHVTLSAT TTDALTVKLK PHEGDTAPLH GYTLHYKPEF GEWETSEVSV 240
  241 DSQKHNIEGL LCGSRYQVYA TGFNNIGAGE ASDILNTRTK GQKPKLPEKP RFIEVSSNSV 300
  301 SLHFKAWKDG GCPMSHFVVE SKKRDQIEWN QISNNVKPDN NYVVLDLEPA TWYNLRITAH 360
  361 NSAGFTVAEY DFATLTVTGG TIAPLDDGSG HGNVHTRIRL PAWMPEWLDL NFMVPLIATV 420
  421 VVVAVGICVV CVALSRRRAD DMRGGQKDVY YDVVYNQT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #8
Region A:
Residues: [1673-1799] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPGATLDKR RPDLRDELGY IAPPNRKLPP VPGSNYNTCD RIKRGRGGLR SNHSTWDPRR  60
   61 NPNLYEELKA PPVPMHGNHY GHAHGNAECH YRHPGMEDEI CPYATFHLLG FREEMDPTKA 120
  121 MNFQTFP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1800-2032] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HQNGHAGPVP GHAGTMLPPG HPGHVHSRSG SQSMPRANRY QRKNSQGGQS SIYTPAPEYD  60
   61 DPANCAEEDQ YRRYTRVNSQ GGSLYSGPGP EYDDPANCAP EEDQYGSQYG GPYGQPYDHY 120
  121 GSRGSMGRRS IGSARNPGNG SPEPPPPPPR NHDMSNSSFN DSKESNEISE AECDRDHGPR 180
  181 GNYGAVKRSP QPKDQRTTEE MRKLIERNET GPKQLQLQQA NGAGFTAYDT MAV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle