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View Structure Prediction Details

Protein: Dscam-PAV
Organism: Drosophila melanogaster
Length: 2034 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PAV.

Description E-value Query
Range
Subject
Range
Dscam-PAR - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
1488.0 [0..3] [2034..3]

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Predicted Domain #1
Region A:
Residues: [1-428]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVHQF YQTRVIDEFV LRGNSATLKC LVPSFVADFI DVEGWIDEEG 180
  181 VEILRPLPDD SVDGKYLVLP SGELHIREVG PEDGYKSYQC RTKHRLTGET RLSATKGRLV 240
  241 ITEPVGSVAP KVDIKDEINY ARVGQDRSLA IVCPAQSYPV PAFRWYKFIE GTTRKQAVVL 300
  301 NDRVKQVSGT LIIKDAVVED SGKYLCVVNN SVGGESVETV LTVTAPLSAK IDPPTQTVDF 360
  361 GRPAVFTCQY TGNPIKTVSW MKDGKAIGHS EPVLRIESVK KEDKGMYQCF VRNDQESAEA 420
  421 SAELKLGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.221849
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [429-537]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFDPPVIRQA FQEETMEPGP SVFLKCVAGG NPTPEISWEL DGKKIANNDR YQVGQYVTVN  60
   61 GDVVSYLNIT SVHANDGGLY KCIAKSKVGV AEHSAKLNVY GLPYIRQME

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 2v9qA
Description: No description for 2v9qA was found.

Predicted Domain #3
Region A:
Residues: [538-820]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKAIVAGETL IVTCPVAGYP IDSIVWERDN RALPINRKQK VFPNGTLIIE NVERNSDQAT  60
   61 YTCVAKNQEG YSARGSLEVQ VMVLPQIVPF DFGEETVNEL DMVSASCTVN KGDLPIDVAW 120
  121 TKNGGRVYTN DGIVVTKTST RMSVLSIESA RARHAGNYSC VATNNAGETR QWAVLAVNVP 180
  181 PRWILEPTDK AFAQGSDAKV ECKADGFPKP QVTWKKAVGD TPGEYKDLKK SDNIRVEEGT 240
  241 LHVDNIQKTN EGYYLCEAIN GIGSGLSAVI MISVQAPPEF TEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.0
Match: 1ry7B
Description: Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
olfactory receptor activity 4.21057154107121 bayes_pls_golite062009
antigen binding 4.06466268219034 bayes_pls_golite062009
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
peptide antigen binding 2.94721224577771 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.83860944503193 bayes_pls_golite062009
growth factor binding 2.28613301180608 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
extracellular matrix structural constituent 1.97667893885412 bayes_pls_golite062009
IgG binding 1.92633562075074 bayes_pls_golite062009
receptor binding 1.70260377709721 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.52958974617075 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.30657787244536 bayes_pls_golite062009
fibroblast growth factor binding 1.27793818082552 bayes_pls_golite062009
fibroblast growth factor receptor activity 1.24730237107473 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
immunoglobulin binding 0.64138121404685 bayes_pls_golite062009
collagen binding 0.635057461053063 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
myosin heavy chain binding 0.49788128784685 bayes_pls_golite062009
cytokine receptor activity 0.34165331857492 bayes_pls_golite062009
protein tyrosine kinase activity 0.318890055375093 bayes_pls_golite062009
immunoglobulin receptor activity 0.117547357032989 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
cell surface binding 0.0515688920405171 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [821-1281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRNQTARRGE PAVLQCEAKG EKPIGILWNM NNMRLDPKND NRYTIREEIL STGVMSSLSI  60
   61 KRTERSDSAL FTCVATNAFG SDDASINMIV QEVPEMPYAL KVLDKSGRSV QLSWAQPYDG 120
  121 NSPLDRYIIE FKRSRASWSE IDRVIVPGHT TEAQVQKLSP ATTYNIRIVA ENAIGTSQSS 180
  181 EAVTIITAEE APSGKPQNIK VEPVNQTTMR VTWKPPPRTE WNGEILGYYV GYKLSNTNSS 240
  241 YVFETINFIT EEGKEHNLEL QNLRVYTQYS VVIQAFNKIG AGPLSEEEKQ FTAEGTPSQP 300
  301 PSDTACTTLT SQTIRVGWVS PPLESANGVI KTYKVVYAPS DEWYDETKRH YKKTASSDTV 360
  361 LHGLKKYTNY TMQVLATTAG GDGVRSVPIH CQTEPDVPEA PTDVKALVMG NAAILVSWRP 420
  421 PAQPNGIITQ YTVYSKAEGA ETETKTQKVP HYQMSFEATE L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.39794
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #5
Region A:
Residues: [1282-1321]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKNKPYEFWV TASTTIGEGQ QSKSIVAMPS DQVPAKIASF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1zlgA
Description: No description for 1zlgA was found.

Predicted Domain #6
Region A:
Residues: [1322-1392]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDTFTATFKE DAKMPCLAVG APQPEITWKI KGVEFSANDR MRVLPDGSLL IKSVNRQDAG  60
   61 DYSCHAENSI A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.69897
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #7
Region A:
Residues: [1393-1598]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDSITHKLIV LAPPQSPHVT LSATTTDALT VKLKPHEGDT APLHGYTLHY KPEFGEWETS  60
   61 EVSVDSQKHN IEGLLCGSRY QVYATGFNNI GAGEASDILN TRTKGQKPKL PEKPRFIEVS 120
  121 SNSVSLHFKA WKDGGCPMSH FVVESKKRDQ IEWNQISNNV KPDNNYVVLD LEPATWYNLR 180
  181 ITAHNSAGFT VAEYDFATLT VTGGTI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 2ibgA
Description: No description for 2ibgA was found.

Predicted Domain #8
Region A:
Residues: [1599-1776]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APLDDGSGHG NVHTRIRLPA WMPEWLDLNF MVPLIATVVV VAVGICVVCV ALSRRRADDM  60
   61 RGGQKDVYYD VVYNQTMGPG ATLDKRRPDL RDELGYIAPP NRKLPPVPGS NYNTCDRIKR 120
  121 GRGGLRSNHS TWDPRRNPNL YEELKAPPVP MHGNHYGHAH GNAECHYRHP GMEDEICP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1777-1862]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YATFHLLGFR EEMDPTKAMN FQTFPHQNGH AGPVPGHAGT MLPPGHPGHV HSRSGSQSMP  60
   61 RANRYQRKNS QGGQSSIYTP APEYDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1863-2034]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PANCAEEDQY RRYTRVNSQG GSLYSGPGPE YDDPANCAPE EDQYGSQYGG PYGQPYDHYG  60
   61 SRGSMGRRSI GSARNPGNGS PEPPPPPPRN HDMSNSSFND SKESNEISEA ECDRDHGPRG 120
  121 NYGAVKRSPQ PKDQRTTEEM RKLIERNETG PKQLQLQQAN GAGFTAYDTM AV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle