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View Structure Prediction Details

Protein: gi|11641415, gi|...
Organism: Homo sapiens
Length: 601 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|11641415, gi|....

Description E-value Query
Range
Subject
Range
gi|114680703 - gi|114680703|ref|XP_001162213.1| PREDICTED: cell division cycle 25B isoform 4 [Pan troglodytes]
0.0 [1..601] [1..601]
gi|119630903, gi... - gi|4757950|ref|NP_004349.1| cell division cycle 25B isoform 2 [Homo sapiens], gi|180173|gb|AAA58416....
0.0 [1..601] [1..566]
gi|248473 - gi|248473|gb|AAB22026.1| Cdc25M2 [Mus sp.]
MPIP2_MOUSE - M-phase inducer phosphatase 2 OS=Mus musculus GN=Cdc25b PE=1 SV=1
0.0 [1..601] [1..576]
gi|30584239, gi|... - gi|60653191|gb|AAX29290.1| cell division cycle 25B [synthetic construct], gi|30584239|gb|AAP36368.1|...
0.0 [1..601] [1..580]
gi|7435156 - gi|7435156|pir||I66868 cdc25B - rat
MPIP2_RAT - M-phase inducer phosphatase 2 OS=Rattus norvegicus GN=Cdc25b PE=1 SV=1
0.0 [1..601] [1..574]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS PVTTLTQTMH  60
   61 DLAGLGSRSR LTHLSLSRRA SESSLSSESS ESSDAGLCMD SPSPMDPHMA EQT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [114-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FEQAIQAASR IIRNEQFAIR RFQSMPVRLL GHSPVLRNIT NSQAPDGRRK SEAGSGAASS  60
   61 SGEDKENVRF 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [184-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WKAGVGALRE EEGACWGGSL ACEDPPLPSW LQDGFVFKMP WKPTHPSSTH ALAEWASRRE  60
   61 AFAQRPSSAP DLMCLSPDRK MEVEELSPLA LGRFSLTPAE GDTEEDDGFV DILESDLKDD 120
  121 DAVPPGMESL ISAPLVKTLE KEEEKDLVMY SKCQRLFRSP SMPCSVIRPI LKRLERPQDR 180
  181 DTPVQNKRRR SVTPPEEQQE 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [384-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEEPKARVLR SKSLCHDEIE NLLDSDHREL IGDYSKAFLL QTVDGKHQDL KYISPETMVA  60
   61 LLTGKFSNIV DKFVIVDCRY PYEYEGGHIK TAVNLPLERD AESFLLKSPI APCSLDKRVI 120
  121 LIFHCEFSSE RGPRMCRFIR ERDRAVNDYP SLYYPEMYIL KGGYKEFFPQ HPNFCEPQDY 180
  181 RPMNHEAFKD ELKTFRLKTR SWAGERSRRE LCSRLQDQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.0
Match: 1cwrA
Description: CDC25b
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.72957395505299 bayes_pls_golite062009
protein binding 1.56606332199727 bayes_pls_golite062009
transferase activity 1.33105059149882 bayes_pls_golite062009
WW domain binding 1.14539899569473 bayes_pls_golite062009
phosphatase activity 0.885629090118187 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.802155325212406 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.71357098492815 bayes_pls_golite062009
catalytic activity 0.687308230067573 bayes_pls_golite062009
protein tyrosine phosphatase activity 0.257287361342848 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle