YRC Public Data Repository - Protein Structure Prediction

Protein:	SMARCE1
Organism:	Homo sapiens
Length:	411 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMARCE1.

Description	E-value	Query Range	Subject Range
SMCE1_MOUSE - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Mus...	1.0E-41	[1..411]	[1..411]
gi\|73965989 - gi\|73965989\|ref\|XP_851010.1\| PREDICTED: similar to SWI/SNF-related matrix-associated actin-dependent...	2.0E-41	[1..411]	[1..411]
gi\|61862520 - gi\|61862520\|ref\|XP_613654.1\| PREDICTED: similar to BAF57 isoform 1 [Bos taurus]	7.0E-40	[1..411]	[1..411]
gi\|123993611, gi... - gi\|61361541\|gb\|AAX42064.1\| SWI/SNF related matrix associated actin dependent regulator of chromatin ... gi\|13937941, gi\|... - gi\|30583191\|gb\|AAP35840.1\| SWI/SNF related, matrix associated, actin dependent regulator of chromati...	3.0E-39	[1..411]	[1..411]
gi\|60653639, gi\|... - gi\|60653641\|gb\|AAX29514.1\| SWI/SNF related matrix associated actin dependent regulator of chromatin ...	3.0E-39	[1..411]	[1..411]
gi\|194378168 - gi\|194378168\|dbj\|BAG57834.1\| unnamed protein product [Homo sapiens] gi\|197102747 - gi\|197102747\|ref\|NP_001127230.1\| SWI/SNF related, matrix associated, actin dependent regulator of ch... gi\|55726577 - gi\|55726577\|emb\|CAH90055.1\| hypothetical protein [Pongo abelii] gi\|109115239 - gi\|109115239\|ref\|XP_001099623.1\| PREDICTED: similar to SWI/SNF-related matrix-associated actin-depen... gi\|114667537 - gi\|114667537\|ref\|XP_001170025.1\| PREDICTED: hypothetical protein LOC454655 isoform 5 [Pan troglodyte...	2.0E-37	[19..411]	[1..393]
gi\|57530577, gi\|... - gi\|57530577\|ref\|NP_001006335.1\| SWI/SNF related, matrix associated, actin dependent regulator of chr...	3.0E-37	[1..410]	[1..410]

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Predicted Domain #1

Region A:
Residues: [1-107]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP  60
   61 KPPKPPDKPL MPYMRYSRKV WDQVKASNPD LKLWEIGKII GGMWRDL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.66
Match:	1wgfA
Description:	Solution structure of the 4th HMG-box of mouse UBF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA binding	4.84246149108405	bayes_pls_golite062009
nucleic acid binding	4.73451137188048	bayes_pls_golite062009
transcription regulator activity	4.70526716815828	bayes_pls_golite062009
transcription factor activity	3.57291699480776	bayes_pls_golite062009
binding	3.45976454780353	bayes_pls_golite062009
transcription repressor activity	2.98484462586223	bayes_pls_golite062009
sequence-specific DNA binding	2.64790748689391	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.54168984559574	bayes_pls_golite062009
transcription activator activity	1.46271038594364	bayes_pls_golite062009
chromatin binding	1.42879477692352	bayes_pls_golite062009
protein binding	1.06660874927515	bayes_pls_golite062009
transcription factor binding	0.97374076531363	bayes_pls_golite062009
DNA bending activity	0.428738547626155	bayes_pls_golite062009
specific transcriptional repressor activity	0.227668272391718	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.0671309267769598	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [108-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDEEKQEYLN EYEAEKIEYN ESMKAYHNSP AYLAYINAKS RAEAALEEES RQRQSRMEKG  60
   61 EPYMSIQPAE DPDDYDDGFS MKHTATARFQ RNHRLISEIL SESVVPDVRS VVTTARMQVL 120
  121 KRQVQSLMVH QRKLEAELLQ IEERHQEKKR KFLESTDSFN NELKRLCGLK VEVDMEKIAA 180
  181 EIAQAEEQAR KRQEEREKEA AEQAERSQSS IVPEEEQAAN KGEEKKDDEN IPMETEETHL 240
  241 EETTESQQNG EEGTSTPEDK ESGQEGVDSM AEEGTSDSNT GSESNSATVE EPPTDPIPED 300
  301 EKKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.69897
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: