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View Structure Prediction Details

Protein: STK24
Organism: Homo sapiens
Length: 443 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STK24.

Description E-value Query
Range
Subject
Range
gi|114650418 - gi|114650418|ref|XP_001143783.1| PREDICTED: serine/threonine kinase 24 (STE20 homolog, yeast) isofor...
0.0 [1..443] [1..443]
gi|109121160 - gi|109121160|ref|XP_001091015.1| PREDICTED: serine/threonine kinase 24 (STE20 homolog, yeast) isofor...
0.0 [1..443] [1..443]
HGNC:11403|MIM:6... - kinase 24 (STE20 homolog, yeast)
gi|61355570, gi|... - gi|61355570|gb|AAX41153.1| serine/threonine kinase 24 [synthetic construct], gi|123980018|gb|ABM8183...
gi|54696106, gi|... - gi|57160731|emb|CAI39457.1| serine/threonine kinase 24 (STE20 homolog, yeast) [Homo sapiens], gi|559...
1.0E-97 [15..443] [3..431]
gi|33304141 - gi|33304141|gb|AAQ02578.1| serine/threonine kinase 24 [synthetic construct]
1.0E-97 [15..443] [3..431]

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Predicted Domain #1
Region A:
Residues: [1-305]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSRAQLWGL ALNKRRATLP HPGGSTNLKA DPEELFTKLE KIGKGSFGEV FKGIDNRTQK  60
   61 VVAIKIIDLE EAEDEIEDIQ QEITVLSQCD SPYVTKYYGS YLKDTKLWII MEYLGGGSAL 120
  121 DLLEPGPLDE TQIATILREI LKGLDYLHSE KKIHRDIKAA NVLLSEHGEV KLADFGVAGQ 180
  181 LTDTQIKRNT FVGTPFWMAP EVIKQSAYDS KADIWSLGIT AIELARGEPP HSELHPMKVL 240
  241 FLIPKNNPPT LEGNYSKPLK EFVEACLNKE PSFRPTAKEL LKHKFILRNA KKTSYLTELI 300
  301 DRYKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.045757
Match: 1u5qA
Description: Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
cytoskeletal protein binding 1.22172815474021 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
nucleic acid binding 0.655396214040669 bayes_pls_golite062009
transcription regulator activity 0.631882811427766 bayes_pls_golite062009
DNA binding 0.599969415455862 bayes_pls_golite062009
tubulin binding 0.525721160726465 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
transcription factor activity 0.457173041568166 bayes_pls_golite062009
actin binding 0.456340967230669 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
microtubule binding 0.191960933574742 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [306-443]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WKAEQSHDDS SSEDSDAETD GQASGGSDSG DWIFTIREKD PKNLENGALQ PSDLDRNKMK  60
   61 DIPKRPFSQC LSTIISPLFA ELKEKSQACG GNLGSIEELR GAIYLAEEAC PGISDTMVAQ 120
  121 LVQRLQRYSL SGGGTSSH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle