YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|21265165, gi\|...
Organism:	Homo sapiens
Length:	478 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|21265165, gi|....

Description	E-value	Query Range	Subject Range
gi\|67668083, gi\|... - gi\|67668083\|ref\|ZP_00465278.1\| General substrate transporter:Major facilitator superfamily [Burkhold...	2.0E-55	[2..437]	[1020..1479]
gi\|125807904, gi... - gi\|54635731\|gb\|EAL25134.1\| GA15593-PA [Drosophila pseudoobscura], gi\|125807904\|ref\|XP_001360559.1\| G...	9.0E-52	[9..453]	[387..852]
gi\|90307566, gi\|... - gi\|90307566\|gb\|EAS37197.1\| hypothetical protein CIMG_02551 [Coccidioides immitis RS], gi\|119196353\|r...	5.0E-51	[1..445]	[233..702]
gi\|169764102 - gi\|169764102\|ref\|XP_001727951.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83770979 - gi\|83770979\|dbj\|BAE61112.1\| unnamed protein product [Aspergillus oryzae]	6.0E-51	[1..454]	[192..670]
TRET1_AEDAE - Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1	8.0E-49	[9..442]	[335..789]
SNF3 - Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmemb... SNF3_YEAST - High-affinity glucose transporter SNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=S...	3.0E-48	[8..439]	[86..556]
gi\|49526727 - gi\|49526727\|emb\|CAG60354.1\| unnamed protein product [Candida glabrata] gi\|50289971, gi\|... - gi\|50289971\|ref\|XP_447417.1\| hypothetical protein CAGL0I03872g [Candida glabrata CBS138], gi\|4952672...	2.0E-47	[21..471]	[118..608]
gi\|50302413, gi\|... - gi\|50302413\|ref\|XP_451141.1\| unnamed protein product [Kluyveromyces lactis], gi\|49640272\|emb\|CAH0272... gi\|49640272 - gi\|49640272\|emb\|CAH02729.1\| KLLA0A03223p [Kluyveromyces lactis]	2.0E-47	[16..457]	[113..579]
gi\|16080636, gi\|... - gi\|2636109\|emb\|CAB15600.1\| ywtG [Bacillus subtilis subsp. subtilis str. 168], gi\|16080636\|ref\|NP_391... gi\|7446721, gi\|1... - pir\|\|E70070 metabolite transport protein homolog ywtG - Bacillus subtilis, gi\|1894771\|emb\|CAB07473.1...	4.0E-47	[20..444]	[7..444]
gi\|60470323, gi\|... - gi\|66816473\|ref\|XP_642246.1\| sugar transporter family protein [Dictyostelium discoideum AX4], gi\|604... gi\|60470323 - gi\|60470323\|gb\|EAL68303.1\| hypothetical protein DDB0205325 [Dictyostelium discoideum]	6.0E-47	[18..437]	[178..623]

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Predicted Domain #1

Region A:
Residues: [1-478]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI FHTTYSEIAW  60
   61 ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM VLASFSSSVV QLYLTMGFIT 120
  121 GLGLAFNLQP ALTIIGKYFY RKRPMANGLA MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI 180
  181 LGSLLLNACV AGSLMRPLGP NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS 240
  241 LFKHRGFLIY LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV 300
  301 GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG FGSVSSVLFE 360
  361 TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT GEYKYMYMSC GAIVVAASVW 420
  421 LLIGNAINYR LLAKERKEEN ARQKTRESEP LSKSKHSEDV NVKVSNAQSV TSERETNI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.522879
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
binding	0.805286077372817	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: