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View Structure Prediction Details

Protein: IMPA1
Organism: Homo sapiens
Length: 277 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMPA1.

Description E-value Query
Range		 Subject
Range
IMPA1_PONPY - Inositol monophosphatase - Pongo pygmaeus (Orangutan)
IMPA1_PONAB - Inositol monophosphatase 1 OS=Pongo abelii GN=IMPA1 PE=2 SV=1
 4.0E-83 [1..277] [1..277]
gi|114620630, gi... - gi|114620632|ref|XP_001168801.1| PREDICTED: inositol(myo)-1(or 4)-monophosphatase 1 isoform 7 [Pan t...
 4.0E-83 [1..277] [60..336]
gi|67971222 - gi|67971222|dbj|BAE01953.1| unnamed protein product [Macaca fascicularis]
 7.0E-83 [1..277] [1..277]
gi|109086796, gi... - gi|109086798|ref|XP_001092711.1| PREDICTED: inositol(myo)-1(or 4)-monophosphatase 1 isoform 2 [Macac...
 9.0E-83 [1..277] [1..277]
gi|2914660, gi|2... - gi|443383|pdb|2HHM|B Chain B, Structure Of Inositol Monophosphatase, The Putative Target Of Lithium ...
 5.0E-82 [2..277] [1..276]
IMPA1_PIG - Inositol monophosphatase 1 OS=Sus scrofa GN=IMPA1 PE=2 SV=1
 3.0E-81 [1..277] [1..277]
IMPA1_BOVIN - Inositol monophosphatase 1 OS=Bos taurus GN=IMPA1 PE=1 SV=1
 6.0E-81 [1..277] [1..277]
gi|57107809 - gi|57107809|ref|XP_535114.1| PREDICTED: similar to Inositol monophosphatase (IMPase) (IMP) (Inositol...
 7.0E-81 [1..277] [1..277]

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Predicted Domain #1
Region A:
Residues: [1-277] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE  60
   61 KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG 120
  121 VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPE TVRMVLSNME 180
  181 KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG 240
  241 GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.69897
Match: 1imaA
Description: Inositol monophosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphatase activity 6.94859134959555 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.73672244222293 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.8594723090245 bayes_pls_golite062009
hydrolase activity 4.43275987578288 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 3.57479316466542 bayes_pls_golite062009
inositol-1(or 4)-monophosphatase activity 3.34662957972704 bayes_pls_golite062009
carbohydrate phosphatase activity 2.20066245856029 bayes_pls_golite062009
catalytic activity 2.13229228332707 bayes_pls_golite062009
fructose 1,6-bisphosphate 1-phosphatase activity 1.61382250100271 bayes_pls_golite062009
3'(2'),5'-bisphosphate nucleotidase activity 1.03636246295147 bayes_pls_golite062009
binding 0.890627780120238 bayes_pls_golite062009
protein binding 0.286223098418614 bayes_pls_golite062009
nucleotidase activity 0.191173184964385 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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