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Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nucleotidase activity
Acc: GO:0008252
Aspect: Molecular Function
Desc: Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.
Synonyms:
  • nucleotide-specific phosphatase activity
  • NSP II
  • NSP I
  • acid nucleotidase activity
  • deoxyinosine-activated nucleotidase (DIAN)
  • deoxyribonucleoside-activated nucleotidase (DAN)
  • nucleotide phosphohydrolase activity
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 76 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008252 - nucleotidase activity (interactive image map)
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Created and Maintained by: Michael Riffle