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View Structure Prediction Details

Protein: RGA3_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 969 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RGA3_SCHPO.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
406.0 [0..2] [338..2533]
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
395.0 [0..2] [534..710]
gi|109125970 - gi|109125970|ref|XP_001115785.1| PREDICTED: similar to zinc finger protein 665 [Macaca mulatta]
389.0 [0..4] [504..253]
gi|114586410 - gi|114586410|ref|XP_526188.2| PREDICTED: zinc finger protein ZFP [Pan troglodytes]
387.0 [0..2] [611..395]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIFRKSISKS PSSKGSTVCF RCGQAFQRRE TPISFGGHMW HKDCFCCTKC DKGLEHSDQM  60
   61 LVQTSDGRPV CSSCAHTCTA CRMRIKDYAL MSGYDSYHRE CFRCHDCRKQ IIDSNFKRDN 120
  121 RTIFCNDCKQ VRHPSRSSDE SADYHNFEVD VTIKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [156-448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TETKSSVESN KSLSIEIMSP QKPPLSPFGG SRDRLVSETP TNMSQAEGGN VPNDGQDSNL  60
   61 ASNSADSLLP SAKNRSFSSF TSFESPMKYD DSFFPISPSI SPLQKVNKQQ QIESPTATFP 120
  121 LSKNTWKNRF HTFHKQSFTP VNDSSSSDSL KPTINEEALD DFAGSASPYK TMSLTDRAEP 180
  181 IVMNGHMRSL HNATSPFRPF SPSYRSSDTH SPRTRSPNVQ THKKTSSQPS DLSSFAQLLS 240
  241 PPQVLSPKPN GGGHKSFRHS HSLSETSQQT LVPSLGSNGE YHLPTNDHSS TPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [449-969]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSERDSDVEE LREQLENLTA LTKKLSERLS SSTFDNSKFI RTEDKDTVRS AKLEICEKFF  60
   61 SFADVTDDPT LKDPKHQDLV AAANAYMAML RESYGTEINN LLERRNELLD DYNNVQKILN 120
  121 ESLEASVHLN TKNLELADLN NNLVKQIQHR VPPENQSNLE HTITTSSKNT TSSINPLTAV 180
  181 SSNSGQSSGR PGPLSPNLNV TTRIDIKGKK GSMHLQPRDV NRKVPFKSMH TKSKSADPVV 240
  241 GNEDRTQCDH VFHVNAIFKP SRCYICSESV WGSELRCFHC SISCHSRCLK RLFAESEHEK 300
  301 TMSETVSENS KWMPEMPTRM PPPGPSPTMF GRSLENQLKI EGSVLPQVIA MCVSCVDAHG 360
  361 LEVEGIYRIS GSASQVRVLV DEFENGSIRM EHLTSDLFAC TSVLKTYLHR LPEPVIPGTQ 420
  421 YEELLEAEKI EKEEEKIERV VEVMKTLHPA HLSVFRFLIA HLGRVCKHAE KNLMNSKNVS 480
  481 TVFAPTLMRD KVNRFDLQHA TKKSTALQFM LDNVDKILHN L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.522879
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Rho GTPase activator activity 4.58620967349979 bayes_pls_golite062009
Rac GTPase activator activity 4.48279904625182 bayes_pls_golite062009
GTPase regulator activity 2.70614727793157 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.68579854252375 bayes_pls_golite062009
binding 2.15139804299723 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.06038764955701 bayes_pls_golite062009
enzyme regulator activity 1.9750017471254 bayes_pls_golite062009
small GTPase regulator activity 1.95738547986197 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
Ras GTPase activator activity 1.09070479183477 bayes_pls_golite062009
cytoskeletal protein binding 1.08705453507613 bayes_pls_golite062009
diacylglycerol binding 1.02792245495259 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 0.967362611034944 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.958295643211986 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
GTPase activator activity 0.717730683557543 bayes_pls_golite062009
actin binding 0.542172162219949 bayes_pls_golite062009
enzyme activator activity 0.298334474872045 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009
Rho GTPase binding 0.150587174126097 bayes_pls_golite062009
transcription regulator activity 0.0455432286632499 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle