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View Structure Prediction Details

Protein: EFNA4
Organism: Homo sapiens
Length: 201 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EFNA4.

Description E-value Query
Range
Subject
Range
gi|157818813, gi... - gi|27693122|ref|XP_227416.1| PREDICTED: similar to Ephrin-A4 precursor (EPH-related receptor tyrosin...
4.0E-69 [1..181] [1..184]
gi|182888041 - gi|182888041|gb|AAI60329.1| Ephrin A4 [synthetic construct]
EFNA4_MOUSE - Ephrin-A4 OS=Mus musculus GN=Efna4 PE=2 SV=2
6.0E-69 [1..182] [1..187]
gi|73961612 - gi|73961612|ref|XP_547555.2| PREDICTED: similar to Ephrin-A4 precursor (EPH-related receptor tyrosin...
2.0E-63 [1..178] [1..181]
gi|155372217, gi... - gi|76612098|ref|XP_873852.1| PREDICTED: similar to LERK-4 isoform 1 [Bos taurus], gi|155372217|ref|N...
7.0E-63 [1..183] [1..186]

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Predicted Domain #1
Region A:
Residues: [1-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLLPLLRTV LWAAFLGSPL RGGSSLRHVV YWNSSNPRLL RGDAVVELGL NDYLDIVCPH  60
   61 YEGPGPPEGP ETFALYMVDW PGYESCQAEG PRAYKRWVCS LPFGHVQFSE KIQRFTPFSL 120
  121 GFEFLPGETY YYISVPTPES SGQCLRLQVS VCCKERKSES AHPVGSPGES GTSGWRGGDT 180
  181 PSPLCLLLLL LLLILRLLRI L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.045757
Match: 1shwA
Description: EphB2 / EphrinA5 Complex Structure
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ephrin receptor binding 2.36859280211986 bayes_pls_golite062009
substrate-specific transporter activity 2.36323002598215 bayes_pls_golite062009
transporter activity 2.349332206525 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.33073133834369 bayes_pls_golite062009
ion transmembrane transporter activity 2.32480642400158 bayes_pls_golite062009
transmembrane transporter activity 2.29776380543181 bayes_pls_golite062009
cation transmembrane transporter activity 2.29241843776882 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.06651640066545 bayes_pls_golite062009
transmembrane receptor activity 1.99582660272933 bayes_pls_golite062009
receptor activity 1.91940799510612 bayes_pls_golite062009
chemorepellent activity 1.90814130005669 bayes_pls_golite062009
copper ion binding 1.80505490229579 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.75949499317195 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.62698854419438 bayes_pls_golite062009
signal transducer activity 1.56471564066129 bayes_pls_golite062009
molecular transducer activity 1.56471564066129 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.56305555927578 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.53842870476418 bayes_pls_golite062009
receptor binding 1.37212317927386 bayes_pls_golite062009
protein tyrosine kinase activity 1.14077883686505 bayes_pls_golite062009
binding 1.13644448710023 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.63330965564582 bayes_pls_golite062009
ephrin receptor activity 0.605684209141979 bayes_pls_golite062009
protein binding 0.2916630712244 bayes_pls_golite062009
transmembrane-ephrin receptor activity 0.188547409516379 bayes_pls_golite062009

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