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View Structure Prediction Details

Protein: ADARB2
Organism: Homo sapiens
Length: 739 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADARB2.

Description E-value Query
Range
Subject
Range
gi|15529506, gi|... - gi|53127005|emb|CAG31002.1| hypothetical protein [Gallus gallus], gi|45383650|ref|NP_989571.1| RNA-s...
0.0 [54..739] [1..701]
gi|27357042 - gi|27357042|gb|AAN86547.1| adenosine deaminase [Takifugu rubripes]
0.0 [1..738] [4..749]
gi|8699065 - gi|8699065|gb|AAF78580.1| RNA adenosine deaminase RED2 [Mus musculus]
0.0 [11..735] [1..731]
gi|148230009, gi... - gi|54648473|gb|AAH84960.1| LOC495438 protein [Xenopus laevis], gi|148230009|ref|NP_001088561.1| aden...
0.0 [54..739] [1..699]
gi|109065066 - gi|109065066|ref|XP_001118216.1| PREDICTED: similar to RNA-specific adenosine deaminase B1 isoform 4...
0.0 [21..738] [96..814]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKHLS PGITNTEDDD  60
   61 TLSTSSAEVK ENRNVGNLAA RPPPSGDRAR GGAPGAKRKR PLEEGNGGHL CKLQLVWKKL 120
  121 SW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [123-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVAPKNALVQ LHELRPGLQY RTVSQTGPVH APVFAVAVEV NGLTFEGTGP TKKKAKMRAA  60
   61 ELALRSFVQF PNAC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.39794
Match: 2b7tA
Description: No description for 2b7tA was found.

Predicted functions:

Term Confidence Notes
double-stranded RNA adenosine deaminase activity 5.04262574612905 bayes_pls_golite062009
RNA binding 4.18713691832357 bayes_pls_golite062009
binding 3.09705138687537 bayes_pls_golite062009
nucleic acid binding 2.95361490759242 bayes_pls_golite062009
DNA binding 1.51133867432475 bayes_pls_golite062009
double-stranded RNA binding 1.46317494664076 bayes_pls_golite062009
protein binding 1.33336414936007 bayes_pls_golite062009
structural constituent of ribosome 1.33042413200827 bayes_pls_golite062009
transcription regulator activity 1.25950932467779 bayes_pls_golite062009
structural molecule activity 1.17628321323282 bayes_pls_golite062009
transcription factor activity 0.42419387757895 bayes_pls_golite062009
protein kinase activity 0.174129357494585 bayes_pls_golite062009
mRNA binding 0.158440222485456 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [197-352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAHLAMGGGP GPGTDFTSDQ ADFPDTLFQE FEPPAPRPGL AGGRPGDAAL LSAAYGRRRL  60
   61 LCRALDLVGP TPATPAAPGE RNPVVLLNRL RAGLRYVCLA EPAERRARSF VMAVSVDGRT 120
  121 FEGSGRSKKL ARGQAAQAAL QELFDIQMPG HAPGRA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 2b7vA
Description: No description for 2b7vA was found.

Predicted functions:

Term Confidence Notes
double-stranded RNA adenosine deaminase activity 5.04262574612905 bayes_pls_golite062009
RNA binding 4.18713691832357 bayes_pls_golite062009
binding 3.09705138687537 bayes_pls_golite062009
nucleic acid binding 2.95361490759242 bayes_pls_golite062009
DNA binding 1.51133867432475 bayes_pls_golite062009
double-stranded RNA binding 1.46317494664076 bayes_pls_golite062009
protein binding 1.33336414936007 bayes_pls_golite062009
structural constituent of ribosome 1.33042413200827 bayes_pls_golite062009
transcription regulator activity 1.25950932467779 bayes_pls_golite062009
structural molecule activity 1.17628321323282 bayes_pls_golite062009
transcription factor activity 0.42419387757895 bayes_pls_golite062009
protein kinase activity 0.174129357494585 bayes_pls_golite062009
mRNA binding 0.158440222485456 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [353-739]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRTPMPQEFA DSISQLVTQK FREVTTDLTP MHARHKALAG IVMTKGLDAR QAQVVALSSG  60
   61 TKCISGEHLS DQGLVVNDCH AEVVARRAFL HFLYTQLELH LSKRREDSER SIFVRLKEGG 120
  121 YRLRENILFH LYVSTSPCGD ARLHSPYEIT TDLHSSKHLV RKFRGHLRTK IESGEGTVPV 180
  181 RGPSAVQTWD GVLLGEQLIT MSCTDKIARW NVLGLQGALL SHFVEPVYLQ SIVVGSLHHT 240
  241 GHLARVMSHR MEGVGQLPAS YRHNRPLLSG VSDAEARQPG KSPPFSMNWV VGSADLEIIN 300
  301 ATTGRRSCGG PSRLCKHVLS ARWARLYGRL STRTPSPGDT PSMYCEAKLG AHTYQSVKQQ 360
  361 LFKAFQKAGL GTWVRKPPEQ QQFLLTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 161.0
Match: 1zy7A
Description: Crystal structure of the catalytic domain of an adenosine deaminase that acts on RNA (hADAR2) bound to inositol hexakisphosphate (IHP)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle