| Protein: | PRMT5 |
| Organism: | Homo sapiens |
| Length: | 637 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRMT5.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [4..637] | [1..644] |
|
|
0.0 | [7..637] | [1..631] |
|
|
0.0 | [12..637] | [19..644] |
|
|
0.0 | [12..637] | [12..637] |
|
|
0.0 | [12..637] | [12..637] |
|
|
0.0 | [12..637] | [12..637] |
|
|
0.0 | [12..637] | [19..644] |
|
Region A: Residues: [1-65] |
1 11 21 31 41 51
| | | | | |
1 MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK 60
61 NRPGP
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [66-277] |
1 11 21 31 41 51
| | | | | |
1 QTRSDLLLSG RDWNTLIVGK LSPWIRPDSK VEKIRRNSEA AMLQELNFGA YLGLPAFLLP 60
61 LNQEDNTNLA RVLTNHIHTG HHSSMFWMRV PLVAPEDLRD DIIENAPTTH TEEYSGEEKT 120
121 WMWWHNFRTL CDYSKRIAVA LEIGADLPSN HVIDRWLGEP IKAAILPTSI FLTNKKGFPV 180
181 LSKMHQRLIF RLLKLEVQFI ITGTNHHSEK EF
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [278-637] |
1 11 21 31 41 51
| | | | | |
1 CSYLQYLEYL SQNRPPPNAY ELFAKGYEDY LQSPLQPLMD NLESQTYEVF EKDPIKYSQY 60
61 QQAIYKCLLD RVPEEEKDTN VQVLMVLGAG RGPLVNASLR AAKQADRRIK LYAVEKNPNA 120
121 VVTLENWQFE EWGSQVTVVS SDMREWVAPE KADIIVSELL GSFADNELSP ECLDGAQHFL 180
181 KDDGVSIPGE YTSFLAPISS SKLYNEVRAC REKDRDPEAQ FEMPYVVRLH NFHQLSAPQP 240
241 CFTFSHPNRD PMIDNNRYCT LEFPVEVNTV LHGFAGYFET VLYQDITLSI RPETHSPGMF 300
301 SWFPILFPIK QPITVREGQT ICVRFWRCSN SKKVWYEWAV TAPVCSAIHN PTGRSYTIGL 360
361
|
| Detection Method: | |
| Confidence: | 56.154902 |
| Match: | 1orhA |
| Description: | Structure of the Predominant Protein Arginine Methyltransferase PRMT1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein-arginine N-methyltransferase activity | 5.52520020727046 | bayes_pls_golite062009 |
| arginine N-methyltransferase activity | 5.52520020727046 | bayes_pls_golite062009 |
| protein methyltransferase activity | 5.03267617653315 | bayes_pls_golite062009 |
| S-adenosylmethionine-dependent methyltransferase activity | 4.4632173842967 | bayes_pls_golite062009 |
| histone methyltransferase activity (H4-R3 specific) | 4.42061797259061 | bayes_pls_golite062009 |
| histone methyltransferase activity | 4.40911163698179 | bayes_pls_golite062009 |
| protein-arginine omega-N monomethyltransferase activity | 4.39379274790202 | bayes_pls_golite062009 |
| methyltransferase activity | 4.15445027778357 | bayes_pls_golite062009 |
| N-methyltransferase activity | 4.07806017452628 | bayes_pls_golite062009 |
| transferase activity, transferring one-carbon groups | 4.07153733729662 | bayes_pls_golite062009 |
| protein-arginine omega-N asymmetric methyltransferase activity | 3.55785970363721 | bayes_pls_golite062009 |
| histone-arginine N-methyltransferase activity | 2.86617323549909 | bayes_pls_golite062009 |
| protein-arginine omega-N symmetric methyltransferase activity | 2.80855981068149 | bayes_pls_golite062009 |
| transferase activity | 2.22303238506686 | bayes_pls_golite062009 |
| DNA-methyltransferase activity | 2.18991764495147 | bayes_pls_golite062009 |
| RNA methyltransferase activity | 1.86200407013263 | bayes_pls_golite062009 |
| rRNA methyltransferase activity | 1.79395300104934 | bayes_pls_golite062009 |
| histone methyltransferase activity (H2A-R3 specific) | 1.49229188826344 | bayes_pls_golite062009 |
| [myelin basic protein]-arginine N-methyltransferase activity | 1.49229188826344 | bayes_pls_golite062009 |
| histone methyltransferase activity (H3-R2 specific) | 1.49229188826344 | bayes_pls_golite062009 |
| catalytic activity | 1.25333584501255 | bayes_pls_golite062009 |
| RNA binding | 1.10729923226801 | bayes_pls_golite062009 |
| binding | 0.976078016260105 | bayes_pls_golite062009 |
| histone binding | 0.964746527369069 | bayes_pls_golite062009 |
| transcription regulator activity | 0.914549843668268 | bayes_pls_golite062009 |
| tRNA methyltransferase activity | 0.868107614027708 | bayes_pls_golite062009 |
| DNA binding | 0.86027591375666 | bayes_pls_golite062009 |
| lysine N-methyltransferase activity | 0.858129308056814 | bayes_pls_golite062009 |
| protein-lysine N-methyltransferase activity | 0.858129308056814 | bayes_pls_golite062009 |
| histone-lysine N-methyltransferase activity | 0.858129308056814 | bayes_pls_golite062009 |
| mRNA methyltransferase activity | 0.73490663449605 | bayes_pls_golite062009 |
| mRNA (guanine-N7-)-methyltransferase activity | 0.73490663449605 | bayes_pls_golite062009 |
| site-specific DNA-methyltransferase (adenine-specific) activity | 0.703178429468566 | bayes_pls_golite062009 |
| nucleic acid binding | 0.616949327277483 | bayes_pls_golite062009 |
| rRNA (adenine) methyltransferase activity | 0.102141401712309 | bayes_pls_golite062009 |
| rRNA (adenine-N6,N6-)-dimethyltransferase activity | 0.0251895714734512 | bayes_pls_golite062009 |
