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View Structure Prediction Details

Protein: PSMD11
Organism: Homo sapiens
Length: 422 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSMD11.

Description E-value Query
Range
Subject
Range
gi|109488638 - gi|109488638|ref|XP_220754.3| PREDICTED: similar to 26S proteasome non-ATPase regulatory subunit 11 ...
2.0E-84 [1..422] [78..499]
gi|74193694 - gi|74193694|dbj|BAE22795.1| unnamed protein product [Mus musculus]
1.0E-78 [1..422] [1..422]
gi|62901920 - gi|62901920|gb|AAY18911.1| unknown [synthetic construct]
4.0E-78 [2..422] [26..446]
gi|2150046 - gi|2150046|gb|AAB58732.1| 26S proteasome subunit 9 [Homo sapiens]
7.0E-78 [1..422] [1..422]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAAVVEFQ RAQSLLSTDR EASIDILHSI VKRDIQENDE EAVQVKEQSI LELGSLLAKT  60
   61 GQAAELGGLL KYVRPFLNSI SKAKAARLVR SLLDLFLDME A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [102-249]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATGQEVELCL ECIEWAKSEK RTFLRQALEA RLVSLYFDTK RYQEALHLGS QLLRELKKMD  60
   61 DKALLVEVQL LESKTYHALS NLPKARAALT SARTTANAIY CPPKLQATLD MQSGIIHAAE 120
  121 EKDWKTAYSY FYEAFEGYDS IDSPKAIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1na0A
Description: Designed protein cTPR3
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [250-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLKYMLLCKI MLNTPEDVQA LVSGKLALRY AGRQTEALKC VAQASKNRSL ADFEKALTDY  60
   61 RAELRDDPII 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [320-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STHLAKLYDN LLEQNLIRVI EPFSRVQIEH ISSLIKLSKA DVERKLSQMI LDKKFHGILD  60
   61 QGEGVLIIFD EPPVDKTYEA ALETIQNMSK VVDSLYNKAK KLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.50995556050336 bayes_pls_golite062009
nucleic acid binding 3.38144578566524 bayes_pls_golite062009
binding 3.33026160538031 bayes_pls_golite062009
DNA binding 3.30822066787723 bayes_pls_golite062009
transcription factor activity 2.60537570879007 bayes_pls_golite062009
hydrolase activity 2.30467124306022 bayes_pls_golite062009
structural constituent of ribosome 1.46680509390433 bayes_pls_golite062009
sequence-specific DNA binding 1.32971938164691 bayes_pls_golite062009
transcription activator activity 1.08566311616647 bayes_pls_golite062009
transcription repressor activity 0.95491822926452 bayes_pls_golite062009
protein binding 0.653872239015235 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.42135864069093 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
small conjugating protein ligase activity 0.118016217031359 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle