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View Structure Prediction Details

Protein: YBX1
Organism: Homo sapiens
Length: 324 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YBX1.

Description E-value Query
Range
Subject
Range
gi|113461768, gi... - gi|113461768|ref|YP_719837.1| large adhesin [Haemophilus somnus 129PT], gi|112823811|gb|ABI25900.1| ...
6.0E-56 [4..321] [1444..1798]
gi|109487472 - gi|109487472|ref|XP_001068252.1| PREDICTED: similar to alpha 3 type VI collagen isoform 1 precursor ...
2.0E-46 [5..322] [2033..2351]
gi|94365373 - gi|94365373|ref|XP_985045.1| PREDICTED: similar to alpha 3 type VI collagen isoform 1 precursor [Mus...
5.0E-46 [5..323] [2009..2322]
gi|114615287 - gi|114615287|ref|XP_510011.2| PREDICTED: similar to DNA-binding protein B [Pan troglodytes]
1.0E-45 [1..324] [57..379]
CO6A1_XENLA - Collagen alpha-1(VI) chain OS=Xenopus laevis GN=col6a1 PE=1 SV=1
1.0E-41 [4..321] [277..592]
CO6A2_CHICK - Collagen alpha-2(VI) chain OS=Gallus gallus GN=COL6A2 PE=2 SV=1
2.0E-41 [4..317] [268..575]

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Predicted Domain #1
Region A:
Residues: [1-128]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEAETQQP PAAPPAAPAL SAADTKPGTT GSGAGSGGPG GLTSAAPAGG DKKVIATKVL  60
   61 GTVKWFNVRN GYGFINRNDT KEDVFVHQTA IKKNNPRKYL RSVGDGETVE FDVVEGEKGA 120
  121 EAANVTGP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 1h95A
Description: Y-box protein 1 cold shock domain (YB1-CSD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.29626483284963 bayes_pls_golite062009
DNA binding 3.71771169141041 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
RNA binding 2.41160981373213 bayes_pls_golite062009
structure-specific DNA binding 2.36519400829041 bayes_pls_golite062009
single-stranded DNA binding 2.17275251213485 bayes_pls_golite062009
transcription regulator activity 2.10110937001387 bayes_pls_golite062009
sequence-specific DNA binding 1.9581702424972 bayes_pls_golite062009
transcription repressor activity 1.30343463892105 bayes_pls_golite062009
transcription activator activity 1.24141936405635 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
transcription factor activity 1.14242112812892 bayes_pls_golite062009
structural constituent of ribosome 1.04824459597896 bayes_pls_golite062009
0.966603287421221 bayes_pls_golite062009
ribonuclease activity 0.702449673647117 bayes_pls_golite062009
structural molecule activity 0.701736942766518 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.583085644017496 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.449277083957511 bayes_pls_golite062009
mRNA binding 0.4162128308402 bayes_pls_golite062009
exoribonuclease activity 0.40223812695012 bayes_pls_golite062009
translation regulator activity 0.31332179848255 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.263197317040851 bayes_pls_golite062009
chromatin binding 0.19409870825073 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.13299060447839 bayes_pls_golite062009
nuclease activity 0.111225677144242 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [129-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGVPVQGSKY AADRNHYRRY PRRRGPPRNY QQNYQNSESG EKNEGSESAP EGQAQQRRPY  60
   61 RRRRFPPYYM RRPYGRRPQY SNPPVQGEVM EGADNQGAGE QGRPVRQNMY RGYRPRFRRG 120
  121 PPRQRQPRED GNEEDKENQG DETQGQQPPQ RRYRRNFNYR RRRPENPKPQ DGKETKAADP 180
  181 PAENSSAPEA EQGGAE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle