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View Structure Prediction Details

Protein: EIF3E
Organism: Homo sapiens
Length: 445 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EIF3E.

Description E-value Query
Range
Subject
Range
gi|60818924 - gi|60818924|gb|AAX36482.1| eukaryotic translation initiation factor 3 subunit 6 [synthetic construct...
0.0 [1..445] [1..445]
gi|17389740 - gi|17389740|gb|AAH17887.1| Eukaryotic translation initiation factor 3, subunit E [Homo sapiens]
0.0 [1..445] [1..445]
EIF3E_BOVIN - Eukaryotic translation initiation factor 3 subunit E OS=Bos taurus GN=EIF3E PE=2 SV=1
0.0 [1..445] [1..445]
EIF3E_CHICK - Eukaryotic translation initiation factor 3 subunit E OS=Gallus gallus GN=EIF3E PE=2 SV=1
0.0 [1..445] [1..445]
gi|55730358 - gi|55730358|emb|CAH91901.1| hypothetical protein [Pongo abelii]
gi|197098998 - gi|197098998|ref|NP_001126100.1| eukaryotic translation initiation factor 3, subunit E [Pongo abelii...
0.0 [1..445] [1..445]
EIF3E_XENTR - Eukaryotic translation initiation factor 3 subunit E OS=Xenopus tropicalis GN=eif3e PE=2 SV=1
0.0 [1..445] [1..446]
EI3EB_XENLA - Eukaryotic translation initiation factor 3 subunit E-B OS=Xenopus laevis GN=eif3e-b PE=2 SV=1
0.0 [1..445] [1..446]

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Predicted Domain #1
Region A:
Residues: [1-130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN  60
   61 LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK 120
  121 HGFRQEYLDT 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 81.0
Match: PF09440.1
Description: No description for PF09440.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [131-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ NWDAAMEDLT  60
   61 RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP QYLNAIQTMC 120
  121 PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY VN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [303-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDFDGAQKKL RECESVLVND FFLVACLEDF IENARLFIFE TFCRIHQCIS INMLADKLNM  60
   61 TPEEAERWIV NLIRNARLDA KIDSKLGHVV MGNNAVSPYQ QVIEKTKSLS FRSQMLAMNI 120
  121 EKKLNQNSRS EAPNWATQDS GFY

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.74
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.83417082121324 bayes_pls_golite062009
DNA binding 4.45307043231712 bayes_pls_golite062009
nucleic acid binding 4.31598146918736 bayes_pls_golite062009
transcription factor activity 3.74401182888821 bayes_pls_golite062009
binding 3.37660003833383 bayes_pls_golite062009
structural constituent of ribosome 2.974370828939 bayes_pls_golite062009
transcription activator activity 2.95095409497726 bayes_pls_golite062009
structural molecule activity 2.72616711594099 bayes_pls_golite062009
RNA binding 2.57915942568691 bayes_pls_golite062009
sequence-specific DNA binding 2.13497236448364 bayes_pls_golite062009
transcription repressor activity 1.87251560747782 bayes_pls_golite062009
protein binding 1.77689943618029 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.30087087585117 bayes_pls_golite062009
mRNA binding 1.03970887182906 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.01831614309793 bayes_pls_golite062009
transcription factor binding 0.675707749846405 bayes_pls_golite062009
hydrolase activity 0.20695163916851 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.142921675412538 bayes_pls_golite062009
small conjugating protein ligase activity 0.124542865343065 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle