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View Structure Prediction Details

Protein: CLN3
Organism: Homo sapiens
Length: 438 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLN3.

Description E-value Query
Range
Subject
Range
CLN3_CANLF - Battenin OS=Canis lupus familiaris GN=CLN3 PE=3 SV=1
0.0 [1..438] [1..438]
gi|55741526 - ref|NP_001006972.1| similar to CLN3 [Rattus norvegicus]
gi|149067889, gi... - gi|55741526|ref|NP_001006972.1| ceroid-lipofuscinosis, neuronal 3 [Rattus norvegicus], gi|53733504|g...
0.0 [1..437] [1..437]
gi|5801851 - gi|5801851|gb|AAD51488.1|AF077966_1 CLN3 protein [Homo sapiens]
0.0 [1..438] [1..438]
CLN3_MACFA - Battenin OS=Macaca fascicularis GN=CLN3 PE=2 SV=1
0.0 [1..438] [1..438]
CLN3_MOUSE - Battenin OS=Mus musculus GN=Cln3 PE=1 SV=1
0.0 [1..437] [1..437]
gi|2388633 - gi|2388633|gb|AAB69984.1| CLN3 [Oryctolagus cuniculus]
0.0 [1..419] [1..419]

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Predicted Domain #1
Region A:
Residues: [1-438]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGCAGSRRR FSDSEGEETV PEPRLPLLDH QGAHWKNAVG FWLLGLCNNF SYVVMLSAAH  60
   61 DILSHKRTSG NQSHVDPGPT PIPHNSSSRF DCNSVSTAAV LLADILPTLV IKLLAPLGLH 120
  121 LLPYSPRVLV SGICAAGSFV LVAFSHSVGT SLCGVVFASI SSGLGEVTFL SLTAFYPRAV 180
  181 ISWWSSGTGG AGLLGALSYL GLTQAGLSPQ QTLLSMLGIP ALLLASYFLL LTSPEAQDPG 240
  241 GEEEAESAAR QPLIRTEAPE SKPGSSSSLS LRERWTVFKG LLWYIVPLVV VYFAEYFINQ 300
  301 GLFELLFFWN TSLSHAQQYR WYQMLYQAGV FASRSSLRCC RIRFTWALAL LQCLNLVFLL 360
  361 ADVWFGFLPS IYLVFLIILY EGLLGGAAYV NTFHNIALET SDEHREFAMA ATCISDTLGI 420
  421 SLSGLLALPL HDFLCQLS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.83
Match: 1pw4A
Description: Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transporter activity 3.82096685159505 bayes_pls_golite062009
transmembrane transporter activity 3.34396155292818 bayes_pls_golite062009
substrate-specific transporter activity 3.32643461660963 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.2506965512085 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.05049771748124 bayes_pls_golite062009
ion transmembrane transporter activity 2.02370427376594 bayes_pls_golite062009
binding 1.9065830290222 bayes_pls_golite062009
cation transmembrane transporter activity 1.62538016506437 bayes_pls_golite062009
active transmembrane transporter activity 1.46819549608723 bayes_pls_golite062009
secondary active transmembrane transporter activity 0.869150152038001 bayes_pls_golite062009
polyol transmembrane transporter activity 0.339747214378126 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.339747214378126 bayes_pls_golite062009
symporter activity 0.327558013224678 bayes_pls_golite062009
solute:cation symporter activity 0.327558013224678 bayes_pls_golite062009
hexose phosphate transmembrane transporter activity 0.273403673499648 bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity 0.273403673499648 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.222664452597504 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle