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View Structure Prediction Details

Protein: NCBP1
Organism: Homo sapiens
Length: 790 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NCBP1.

Description E-value Query
Range
Subject
Range
gi|114625872 - gi|114625872|ref|XP_520138.2| PREDICTED: nuclear cap binding protein subunit 1, 80kDa [Pan troglodyt...
0.0 [1..790] [122..911]
gi|62088046 - gi|62088046|dbj|BAD92470.1| nuclear cap binding protein subunit 1, 80kDa variant [Homo sapiens]
0.0 [1..790] [14..803]
NCBP1_MOUSE - Nuclear cap-binding protein subunit 1 OS=Mus musculus GN=Ncbp1 PE=1 SV=2
0.0 [1..790] [1..790]
gi|73971412 - gi|73971412|ref|XP_532003.2| PREDICTED: similar to 80 kDa nuclear cap binding protein (NCBP 80 kDa s...
tr|M3VW75|M3VW75... - Nuclear cap binding protein subunit 1 OS=Felis catus GN=NCBP1 PE=4 SV=1
0.0 [1..790] [1..790]
gi|76624706 - gi|76624706|ref|XP_873000.1| PREDICTED: similar to 80 kDa nuclear cap binding protein (NCBP 80 kDa s...
0.0 [1..790] [1..783]
NCBP1_RAT - Nuclear cap-binding protein subunit 1 OS=Rattus norvegicus GN=Ncbp1 PE=1 SV=1
0.0 [1..790] [1..790]

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Predicted Domain #1
Region A:
Residues: [1-790]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRRRHSDEN DGGQPHKRRK TSDANETEDH LESLICKVGE KSACSLESNL EGLAGVLEAD  60
   61 LPNYKSKILR LLCTVARLLP EKLTIYTTLV GLLNARNYNF GGEFVEAMIR QLKESLKANN 120
  121 YNEAVYLVRF LSDLVNCHVI AAPSMVAMFE NFVSVTQEED VPQVRRDWYV YAFLSSLPWV 180
  181 GKELYEKKDA EMDRIFANTE SYLKRRQKTH VPMLQVWTAD KPHPQEEYLD CLWAQIQKLK 240
  241 KDRWQERHIL RPYLAFDSIL CEALQHNLPP FTPPPHTEDS VYPMPRVIFR MFDYTDDPEG 300
  301 PVMPGSHSVE RFVIEENLHC IIKSHWKERK TCAAQLVSYP GKNKIPLNYH IVEVIFAELF 360
  361 QLPAPPHIDV MYTTLLIELC KLQPGSLPQV LAQATEMLYM RLDTMNTTCV DRFINWFSHH 420
  421 LSNFQFRWSW EDWSDCLSQD PESPKPKFVR EVLEKCMRLS YHQRILDIVP PTFSALCPAN 480
  481 PTCIYKYGDE SSNSLPGHSV ALCLAVAFKS KATNDEIFSI LKDVPNPNQD DDDDEGFSFN 540
  541 PLKIEVFVQT LLHLAAKSFS HSFSALAKFH EVFKTLAESD EGKLHVLRVM FEVWRNHPQM 600
  601 IAVLVDKMIR TQIVDCAAVA NWIFSSELSR DFTRLFVWEI LHSTIRKMNK HVLKIQKELE 660
  661 EAKEKLARQH KRRSDDDDRS SDRKDGVLEE QIERLQEKVE SAQSEQKNLF LVIFQRFIMI 720
  721 LTEHLVRCET DGTSVLTPWY KNCIERLQQI FLQHHQIIQQ YMVTLENLLF TAELDPHILA 780
  781 VFQQFCALQA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1n52A
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA cap binding 6.31996430626206 bayes_pls_golite062009
RNA binding 4.20683443264388 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein binding 2.78733902345842 bayes_pls_golite062009
nucleic acid binding 2.74745843355294 bayes_pls_golite062009
mRNA binding 2.49094746544717 bayes_pls_golite062009
transcription regulator activity 2.16673352512615 bayes_pls_golite062009
DNA binding 1.95242774903625 bayes_pls_golite062009
structural molecule activity 1.49689395735141 bayes_pls_golite062009
transcription activator activity 1.33885628961586 bayes_pls_golite062009
transcription factor activity 1.20660383756339 bayes_pls_golite062009
cytoskeletal protein binding 1.03835316513447 bayes_pls_golite062009
RNA 7-methylguanosine cap binding 0.841392474686331 bayes_pls_golite062009
hydrolase activity 0.42501390959416 bayes_pls_golite062009
actin binding 0.278432079866074 bayes_pls_golite062009
transcription factor binding 0.0221966060394205 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle