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View Structure Prediction Details

Protein: ATG4A
Organism: Homo sapiens
Length: 398 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATG4A.

Description E-value Query
Range
Subject
Range
gi|74008589 - gi|74008589|ref|XP_538136.2| PREDICTED: similar to autophagy-related cysteine endopeptidase 2 isofor...
0.0 [1..398] [63..460]
gi|15487240 - gi|15487240|emb|CAC69076.1| putative autophagy-related cysteine endopeptidase 2 [Homo sapiens]
0.0 [1..398] [1..398]
ATG4A_PONPY - Cysteine protease ATG4A - Pongo pygmaeus (Orangutan)
ATG4A_PONAB - Cysteine protease ATG4A OS=Pongo abelii GN=ATG4A PE=2 SV=1
0.0 [1..398] [1..398]
gi|114689790 - gi|114689790|ref|XP_529098.2| PREDICTED: autophagy-related cysteine endopeptidase 2 isoform 8 [Pan t...
0.0 [1..398] [1..398]
gi|109131850 - gi|109131850|ref|XP_001097251.1| PREDICTED: similar to autophagy-related cysteine endopeptidase 2 is...
0.0 [1..398] [1..398]
ATG4A_BOVIN - Cysteine protease ATG4A OS=Bos taurus GN=ATG4A PE=2 SV=1
0.0 [1..398] [1..398]
ATG4A_MOUSE - Cysteine protease ATG4A OS=Mus musculus GN=Atg4a PE=2 SV=2
0.0 [1..398] [1..395]

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Predicted Domain #1
Region A:
Residues: [1-398]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESVLSKYED QITIFTDYLE EYPDTDELVW ILGKQHLLKT EKSKLLSDIS ARLWFTYRRK  60
   61 FSPIGGTGPS SDAGWGCMLR CGQMMLAQAL ICRHLGRDWS WEKQKEQPKE YQRILQCFLD 120
  121 RKDCCYSIHQ MAQMGVGEGK SIGEWFGPNT VAQVLKKLAL FDEWNSLAVY VSMDNTVVIE 180
  181 DIKKMCRVLP LSADTAGDRP PDSLTASNQS KGTSAYCSAW KPLLLIVPLR LGINQINPVY 240
  241 VDAFKECFKM PQSLGALGGK PNNAYYFIGF LGDELIFLDP HTTQTFVDTE ENGTVNDQTF 300
  301 HCLQSPQRMN ILNLDPSVAL GFFCKEEKDF DNWCSLVQKE ILKENLRMFE LVQKHPSHWP 360
  361 PFVPPAKPEV TTTGAEFIDS TEQLEEFDLE EDFEILSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 155.0
Match: 2p82A
Description: No description for 2p82A was found.

Predicted functions:

Term Confidence Notes
peptidase activity 4.90619850296986 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.64381885397949 bayes_pls_golite062009
endopeptidase activity 3.75054525912786 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
hydrolase activity 2.66167923792227 bayes_pls_golite062009
binding 2.49172648273202 bayes_pls_golite062009
small conjugating protein-specific protease activity 2.06332547782769 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
microtubule binding 1.80986894246631 bayes_pls_golite062009
tubulin binding 1.65326788939069 bayes_pls_golite062009
cytoskeletal protein binding 1.61845762872724 bayes_pls_golite062009
ubiquitin-specific protease activity 1.43988355875744 bayes_pls_golite062009
nucleic acid binding 1.38318152877128 bayes_pls_golite062009
transcription regulator activity 1.34325826373515 bayes_pls_golite062009
DNA binding 1.31096468235949 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.774177093888744 bayes_pls_golite062009
transcription activator activity 0.725305894454674 bayes_pls_golite062009
transporter activity 0.69523261160023 bayes_pls_golite062009
transcription factor activity 0.656405451523439 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
transmembrane transporter activity 0.439003000540428 bayes_pls_golite062009
structural molecule activity 0.297752217869698 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
substrate-specific transporter activity 0.125654358663332 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0241561776323942 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle