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View Structure Prediction Details

Protein: IGHG4
Organism: Homo sapiens
Length: 327 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IGHG4.

Description E-value Query
Range
Subject
Range
gi|184848 - gi|184848|gb|AAA73002.1| [Human Ig rearranged gamma chain mRNA, V-J-C region and complete cds.], gen...
1.0E-59 [2..323] [24..346]
gi|9665263|gb|AA... - FV/M4 [synthetic construct]
gi|9665263 - gi|9665263|gb|AAB37424.2| FV/M4 [synthetic construct]
1.0E-51 [3..327] [152..487]

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Predicted Domain #1
Region A:
Residues: [1-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS  60
   61 GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPSCP APEFLGGPSV 120
  121 FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY 180
  181 RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK 240
  241 NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG 300
  301 NVFSCSVMHE ALHNHYTQKS LSLSLGK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.39794
Match: 1hzhH
Description: Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma; Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma; Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antigen binding 6.15874156332332 bayes_pls_golite062009
peptide antigen binding 3.64034637674979 bayes_pls_golite062009
binding 1.98262954718581 bayes_pls_golite062009
receptor activity 1.9202781107236 bayes_pls_golite062009
receptor binding 1.67130413402976 bayes_pls_golite062009
IgG binding 1.6222936767122 bayes_pls_golite062009
transmembrane receptor activity 1.50492718932189 bayes_pls_golite062009
signal transducer activity 1.11174153927545 bayes_pls_golite062009
molecular transducer activity 1.11174153927545 bayes_pls_golite062009
immunoglobulin receptor activity 1.06402558628866 bayes_pls_golite062009
protein binding 0.925738463571838 bayes_pls_golite062009
immunoglobulin binding 0.48272957113121 bayes_pls_golite062009
cytokine binding 0.372406716355349 bayes_pls_golite062009
MHC class II receptor activity 0.251167772391909 bayes_pls_golite062009
growth factor binding 0.0566162403218091 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle