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View Structure Prediction Details

Protein: INO1
Organism: Saccharomyces cerevisiae
Length: 533 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INO1.

Description E-value Query
Range		 Subject
Range
INO1_TOBAC - Inositol-3-phosphate synthase OS=Nicotiana tabacum PE=2 SV=1
 0.0 [9..531] [3..510]
INO1_NICPA - Inositol-3-phosphate synthase OS=Nicotiana paniculata GN=INPS1 PE=2 SV=1
 0.0 [9..531] [3..510]
INO1_SESIN - Inositol-3-phosphate synthase OS=Sesamum indicum PE=2 SV=1
 0.0 [9..531] [3..510]
gi|32492882 - gi|32492882|gb|AAP85531.1| myo-inositol-1-phosphate synthase INO1 [Xerophyta viscosa]
 0.0 [9..531] [3..510]
INO1_WHEAT - Inositol-3-phosphate synthase OS=Triticum aestivum GN=MIPS PE=2 SV=1
 0.0 [9..531] [3..510]
INO1_MESCR - Inositol-3-phosphate synthase OS=Mesembryanthemum crystallinum PE=2 SV=1
 0.0 [9..531] [3..512]
INO1_ORYSA - (O64437) Inositol-3-phosphate synthase (EC 5.5.1.4) (Myo-inositol-1-phosphate synthase) (MI-1-P synt...
gi|3062907 - gi|3062907|dbj|BAA25729.1| myo-inositol phosphate synthase [Oryza sativa Japonica Group]
 0.0 [9..531] [3..510]
gi|18181983 - gi|18181983|dbj|BAB40956.2| myo-inositol-1-phosphate synthase [Avena sativa]
 0.0 [9..531] [3..510]
gi|11762100, gi|... - gi|162464293|ref|NP_001105552.1| low phytic acid1 [Zea mays], gi|11762100|gb|AAG40328.1| myo-inosito...
 0.0 [9..531] [3..510]
INO3_ARATH - Probable inositol 3-phosphate synthase isozyme 3 OS=Arabidopsis thaliana GN=IPS3 PE=1 SV=1
 0.0 [9..531] [3..510]

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Predicted Domain #1
Region A:
Residues: [1-181] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEDNIAPIT SVKVVTDKCT YKDNELLTKY SYENAVVTKT ASGRFDVTPT VQDYVFKLDL  60
   61 KKPEKLGIML IGLGGNNGST LVASVLANKH NVEFQTKEGV KQPNYFGSMT QCSTLKLGID 120
  121 AEGNDVYAPF NSLLPMVSPN DFVVSGWDIN NADLYEAMQR SQVLEYDLQQ RLKAKMSLVK 180
  181 P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
inositol-3-phosphate synthase activity 5.14101880075866 bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity 4.83517188189564 bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity 4.46099072756569 bayes_pls_golite062009
intramolecular lyase activity 3.61355415766141 bayes_pls_golite062009
catalytic activity 2.54843319568228 bayes_pls_golite062009
glucose-6-phosphate dehydrogenase activity 1.31087146124678 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 0.503001902398942 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.461954393123963 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.38381420992976 bayes_pls_golite062009
binding 0.382774999529641 bayes_pls_golite062009
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity 0.375786741986945 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 0.0028371262047614 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [182-533] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPSIYYPDFI AANQDERANN CINLDEKGNV TTRGKWTHLQ RIRRDIQNFK EENALDKVIV  60
   61 LWTANTERYV EVSPGVNDTM ENLLQSIKND HEEIAPSTIF AAASILEGVP YINGSPQNTF 120
  121 VPGLVQLAEH EGTFIAGDDL KSGQTKLKSV LAQFLVDAGI KPVSIASYNH LGNNDGYNLS 180
  181 APKQFRSKEI SKSSVIDDII ASNDILYNDK LGKKVDHCIV IKYMKPVGDS KVAMDEYYSE 240
  241 LMLGGHNRIS IHNVCEDSLL ATPLIIDLLV MTEFCTRVSY KKVDPVKEDA GKFENFYPVL 300
  301 TFLSYWLKAP LTRPGFHPVN GLNKQRTALE NFLRLLIGLP SQNELRFEER LL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.30103
Match: 1vjpA_
Description: Crystal structure of MYO-inositol-1-phosphate synthase-related protein (TM1419) from Thermotoga maritima at 1.70 A resolution
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle