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View Structure Prediction Details

Protein: CUP9
Organism: Saccharomyces cerevisiae
Length: 306 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUP9.

Description E-value Query
Range
Subject
Range
CUP9_YEAST - Homeobox protein CUP9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CUP9 PE=1 SV=1
gi|190407784 - gi|190407784|gb|EDV11049.1| DNA binding protein [Saccharomyces cerevisiae RM11-1a]
CUP9 - Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter;...
5.0E-57 [1..306] [1..306]
HSBH1_SOYBN - Homeobox protein SBH1 OS=Glycine max GN=H1 PE=2 SV=1
3.0E-51 [17..257] [145..378]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-49 [17..238] [108..322]
gi|18389212 - gi|18389212|gb|AAL67665.1| invaginata [Antirrhinum majus]
2.0E-49 [17..249] [119..341]
KNAT6_ARATH - Homeobox protein knotted-1-like 6 OS=Arabidopsis thaliana GN=KNAT6 PE=1 SV=1
2.0E-49 [17..238] [106..322]
gi|26185808 - gi|26185808|emb|CAD58394.1| putative knotted-1-like protein [Helianthus tuberosus]
2.0E-48 [17..238] [115..344]
gi|27413549 - gi|27413549|gb|AAO11694.1| Knotted-1-like homeobox protein H1 [Nicotiana tabacum]
2.0E-48 [17..238] [108..323]
gi|22074785 - gi|22074785|gb|AAM47027.1| shootmeristemless-like [Petunia x hybrida]
3.0E-48 [17..238] [106..327]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYNCEIQNR NSKNVDNQVS LPPIQVLFNS IEKRSMPELA FSNIEYSHGN LRSSTEEQNY  60
   61 PAPVLLPQHH SIAYPAINSG GTSTTATPTA STVETSKTSS SAMDTQSQYG SSKKSKSASD 120
  121 DAKPCYK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [128-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAPIYEIINK EKDAGAQYNR PFSDFVESKS RRKQNSGRRS NLPKETVQIL NTWLLNHLNN  60
   61 PYPTQQEKRE LLIKTGLTKI QLSNWFINVR RRKIFSDYYT LVNSIPNDNA NNTPVERVQN 120
  121 VSAYHNTLSA TNNTMYDATS TCSTDYELSK RFAHAPVTRR KKLIDRLEEL KKLSNPDMN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.0
Match: 1b72B_
Description: pbx1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.37652234273616 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle