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View Structure Prediction Details

Protein: CUP9
Organism: Saccharomyces cerevisiae
Length: 306 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUP9.

Description E-value Query
Range
Subject
Range
CUP9_YEAST - Homeobox protein CUP9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CUP9 PE=1 SV=1
gi|190407784 - gi|190407784|gb|EDV11049.1| DNA binding protein [Saccharomyces cerevisiae RM11-1a]
CUP9 - Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter;...
5.0E-57 [1..306] [1..306]
HSBH1_SOYBN - Homeobox protein SBH1 OS=Glycine max GN=H1 PE=2 SV=1
3.0E-51 [17..257] [145..378]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-49 [17..238] [108..322]
gi|18389212 - gi|18389212|gb|AAL67665.1| invaginata [Antirrhinum majus]
2.0E-49 [17..249] [119..341]
KNAT6_ARATH - Homeobox protein knotted-1-like 6 OS=Arabidopsis thaliana GN=KNAT6 PE=1 SV=1
2.0E-49 [17..238] [106..322]
gi|26185808 - gi|26185808|emb|CAD58394.1| putative knotted-1-like protein [Helianthus tuberosus]
2.0E-48 [17..238] [115..344]
gi|27413549 - gi|27413549|gb|AAO11694.1| Knotted-1-like homeobox protein H1 [Nicotiana tabacum]
2.0E-48 [17..238] [108..323]
gi|22074785 - gi|22074785|gb|AAM47027.1| shootmeristemless-like [Petunia x hybrida]
3.0E-48 [17..238] [106..327]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYNCEIQNR NSKNVDNQVS LPPIQVLFNS IEKRSMPELA FSNIEYSHGN LRSSTEEQNY  60
   61 PAPVLLPQHH SIAYPAINSG GTSTTATPTA STVETSKTSS SAMDTQSQYG SSKKSKSASD 120
  121 DAKPCYK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.253 0.212 specific RNA polymerase II transcription factor activity a.1.1 Globin-like
View Download 0.255 0.024 specific RNA polymerase II transcription factor activity a.91.1 Regulator of G-protein signalling, RGS
View Download 0.391 0.014 specific RNA polymerase II transcription factor activity c.53.1 Resolvase-like
View Download 0.495 0.006 specific RNA polymerase II transcription factor activity a.18.1 T4 endonuclease V
View Download 0.495 N/A N/A a.18.1 T4 endonuclease V
View Download 0.391 N/A N/A c.53.1 Resolvase-like
View Download 0.255 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.253 N/A N/A a.1.1 Globin-like

Predicted Domain #2
Region A:
Residues: [128-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAPIYEIINK EKDAGAQYNR PFSDFVESKS RRKQNSGRRS NLPKETVQIL NTWLLNHLNN  60
   61 PYPTQQEKRE LLIKTGLTKI QLSNWFINVR RRKIFSDYYT LVNSIPNDNA NNTPVERVQN 120
  121 VSAYHNTLSA TNNTMYDATS TCSTDYELSK RFAHAPVTRR KKLIDRLEEL KKLSNPDMN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.0
Match: 1b72B_
Description: pbx1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.37652234273616 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle