YRC Public Data Repository - Protein Structure Prediction

Protein:	OYE3
Organism:	Saccharomyces cerevisiae
Length:	400 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OYE3.

Description	E-value	Query Range	Subject Range
OYE3 - Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slig... OYE3_YEAST - NADPH dehydrogenase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OYE3 PE=1 SV=2	0.0	[1..400]	[1..400]
gi\|23126675, gi\|... - gi\|23126675\|ref\|ZP_00108564.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Nosto...	0.0	[11..392]	[1..363]
gi\|5701740 - gi\|5701740\|dbj\|BAA83083.1\| LEDI-5a protein [Lithospermum erythrorhizon]	0.0	[10..395]	[1..369]
gi\|17130955, gi\|... - gi\|17229357\|ref\|NP_485905.1\| hypothetical protein all1865 [Nostoc sp. PCC 7120], gi\|17130955\|dbj\|BAB... gi\|25325984 - pir\|\|AC2039 hypothetical protein all1865 [imported] - Nostoc sp. (strain PCC 7120)	0.0	[6..392]	[33..400]
gi\|77633724, gi\|... - gi\|77633724\|ref\|ZP_00795843.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Yersi... gi\|153950748, gi... - gi\|77629364\|ref\|ZP_00791950.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Yersi... gi\|165990445, gi... - gi\|166010743\|ref\|ZP_02231641.1\| oxidoreductase, FAD/FMN-binding [Yersinia pestis biovar Antiqua str.... gi\|165921640, gi... - gi\|165926419\|ref\|ZP_02222251.1\| oxidoreductase, FAD/FMN-binding [Yersinia pestis biovar Orientalis s... gi\|149292123, gi... - gi\|149365710\|ref\|ZP_01887745.1\| NADH:flavin oxidoreductase / NADH oxidase family protein [Yersinia p... gi\|145598070, gi... - gi\|145598070\|ref\|YP_001162146.1\| N-ethylmaleimide reductase [Yersinia pestis Pestoides F], gi\|145209... gi\|108807720, gi... - gi\|108807720\|ref\|YP_651636.1\| N-ethylmaleimide reductase [Yersinia pestis Antiqua], gi\|108779633\|gb\|... gi\|229680641, gi... - gi\|229902306\|ref\|ZP_04517426.1\| NADH:flavin oxidoreductase / NADH oxidase family protein [Yersinia p... gi\|89103792, gi\|... - gi\|89103792\|ref\|ZP_01176356.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Yersi... gi\|167400926, gi... - gi\|167400926\|ref\|ZP_02306432.1\| oxidoreductase, FAD/FMN-binding [Yersinia pestis biovar Antiqua str.... gi\|166207777, gi... - gi\|166210597\|ref\|ZP_02236632.1\| oxidoreductase, FAD/FMN-binding [Yersinia pestis biovar Antiqua str.... gi\|25325966 - pir\|\|AD0290 NADH flavin oxidoreductase / NADH oxidase family protein YPO2379 [imported] - Yersinia p... gi\|167470352 - gi\|167470352\|ref\|ZP_02335056.1\| oxidoreductase, FAD/FMN-binding protein [Yersinia pestis FV-1] gi\|229837903, gi... - gi\|229837903\|ref\|ZP_04458062.1\| NADH:flavin oxidoreductase / NADH oxidase family protein [Yersinia p... gi\|166958908, gi... - gi\|167422096\|ref\|ZP_02313849.1\| oxidoreductase, FAD/FMN-binding [Yersinia pestis biovar Orientalis s... gi\|229701952, gi... - gi\|229895064\|ref\|ZP_04510241.1\| NADH:flavin oxidoreductase / NADH oxidase family protein [Yersinia p... gi\|218929470, gi... - gi\|218929470\|ref\|YP_002347345.1\| N-ethylmaleimide reductase [Yersinia pestis CO92], gi\|16122602\|ref\|... gi\|229688510, gi... - gi\|229898466\|ref\|ZP_04513612.1\| NADH:flavin oxidoreductase / NADH oxidase family protein [Yersinia p... gi\|45441957, gi\|... - gi\|45441957\|ref\|NP_993496.1\| N-ethylmaleimide reductase [Yersinia pestis biovar Microtus str. 91001]... gi\|170024110, gi... - gi\|170024110\|ref\|YP_001720615.1\| N-ethylmaleimide reductase [Yersinia pseudotuberculosis YPIII], gi\|...	0.0	[12..389]	[1..365]
gi\|125619970, gi... - gi\|75831420\|ref\|ZP_00760684.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Vibri... gi\|121726403, gi... - gi\|75817101\|ref\|ZP_00747556.1\| COG1902: NADH:flavin oxidoreductases, Old Yellow Enzyme family [Vibri... gi\|9658435, gi\|1... - gi\|9658435\|gb\|AAF96889.1\| N-ethylmaleimide reductase [Vibrio cholerae O1 biovar eltor str. N16961], ... gi\|11280134 - pir\|\|C82391 N-ethylmaleimide reductase VCA0993 [imported] - Vibrio cholerae (strain N16961 serogroup... gi\|121587041, gi... - gi\|121587041\|ref\|ZP_01676819.1\| N-ethylmaleimide reductase [Vibrio cholerae 2740-80], gi\|121548776\|g... gi\|124119449, gi... - gi\|153221694\|ref\|ZP_01952599.1\| N-ethylmaleimide reductase [Vibrio cholerae MAK 757], gi\|124119449\|g... gi\|153818192, gi... - gi\|153818192\|ref\|ZP_01970859.1\| N-ethylmaleimide reductase [Vibrio cholerae NCTC 8457], gi\|126511298... gi\|227812558, gi... - gi\|227812558\|ref\|YP_002812568.1\| N-ethylmaleimide reductase [Vibrio cholerae M66-2], gi\|227011700\|gb... gi\|229352719, gi... - gi\|229510274\|ref\|ZP_04399754.1\| 2,4-dienoyl-CoA reductase [NADPH] [Vibrio cholerae B33], gi\|22935271... gi\|229505872, gi... - gi\|229505872\|ref\|ZP_04395381.1\| 2,4-dienoyl-CoA reductase [NADPH] [Vibrio cholerae BX 330286], gi\|22... gi\|229517595, gi... - gi\|229517595\|ref\|ZP_04407040.1\| 2,4-dienoyl-CoA reductase [NADPH] [Vibrio cholerae RC9], gi\|22934563... gi\|229605405, gi... - gi\|229605405\|ref\|YP_002876109.1\| 2,4-dienoyl-CoA reductase (NADPH) [Vibrio cholerae MJ-1236], gi\|229...	0.0	[14..392]	[1..365]
OYE1_SACPS - NADPH dehydrogenase 1 OS=Saccharomyces pastorianus GN=OYE1 PE=1 SV=3 gi\|320802 - pir\|\|A39495 NADPH2 dehydrogenase (EC 1.6.99.1) chain OYE1 - yeast (Saccharomyces cerevisiae) (strai...	0.0	[1..399]	[1..399]

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Predicted Domain #1

Region A:
Residues: [1-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFVKGFEPI SLRDTNLFEP IKIGNTQLAH RAVMPPLTRM RATHPGNIPN KEWAAVYYGQ  60
   61 RAQRPGTMII TEGTFISPQA GGYDNAPGIW SDEQVAEWKN IFLAIHDCQS FAWVQLWSLG 120
  121 WASFPDVLAR DGLRYDCASD RVYMNATLQE KAKDANNLEH SLTKDDIKQY IKDYIHAAKN 180
  181 SIAAGADGVE IHSANGYLLN QFLDPHSNKR TDEYGGTIEN RARFTLEVVD ALIETIGPER 240
  241 VGLRLSPYGT FNSMSGGAEP GIIAQYSYVL GELEKRAKAG KRLAFVHLVE PRVTDPSLVE 300
  301 GEGEYSEGTN DFAYSIWKGP IIRAGNYALH PEVVREQVKD PRTLIGYGRF FISNPDLVYR 360
  361 LEEGLPLNKY DRSTFYTMSA EGYTDYPTYE EAVDLGWNKN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10110.0
Match:	1oya__
Description:	Old yellow enzyme (OYE)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.50791144647902	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	2.11027907327307	bayes_pls_golite062009
catalytic activity	1.94749091175302	bayes_pls_golite062009
coenzyme binding	0.99234662301893	bayes_pls_golite062009
binding	0.724672865863266	bayes_pls_golite062009
nucleic acid binding	0.350068675013616	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.0276497014195508	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: