YRC Public Data Repository - Protein Structure Prediction

Protein:	DCI1
Organism:	Saccharomyces cerevisiae
Length:	271 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCI1.

Description	E-value	Query Range	Subject Range
gi\|241218800, gi... - gi\|241769557\|ref\|ZP_04766976.1\| Enoyl-CoA hydratase/isomerase [Sulfolobus solfataricus 98/2], gi\|241... gi\|25291790 - pir\|\|A90436 enoyl CoA hydratase (paaF-7) [imported] - Sulfolobus solfataricus gi\|13815932, gi\|... - gi\|15899349\|ref\|NP_343954.1\| enoyl CoA hydratase (paaF-7) [Sulfolobus solfataricus P2], gi\|13815932\|...	4.0E-76	[1..270]	[8..260]
gi\|15920248, gi\|... - gi\|15920248\|ref\|NP_375917.1\| 3-hydroxybutyryl-CoA dehydrogenase [Sulfolobus tokodaii str. 7], gi\|156...	1.0E-73	[4..268]	[399..647]
gi\|1903327 - gi\|1903327\|emb\|CAB07495.1\| crotonase [Thermoanaerobacterium thermosaccharolyticum] gi\|1903327\|emb\|C... - crotonase [Thermoanaerobacterium thermosaccharolyticum]	2.0E-73	[5..269]	[6..256]
gi\|14601435, gi\|... - gi\|5105168\|dbj\|BAA80482.1\| 659aa long hypothetical 3-hydroxybutyryl-CoA dehydratase [Aeropyrum perni... gi\|7450200 - pir\|\|D72628 probable 3-hydroxybutyryl-CoA dehydratase APE1484 - Aeropyrum pernix (strain K1)	1.0E-72	[3..269]	[404..655]
gi\|18145966, gi\|... - gi\|18311283\|ref\|NP_563217.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens str. 13], gi\|... gi\|110673862, gi... - gi\|110799215\|ref\|YP_696975.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens ATCC 13124],... gi\|182625533, gi... - gi\|182625533\|ref\|ZP_02953304.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens D str. JGS... gi\|170715197, gi... - gi\|170715197\|gb\|EDT27379.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens CPE str. F4969...	4.0E-72	[5..269]	[6..256]
gi\|7428375 - pir\|\|C69370 probable enoyl-CoA hydratase (EC 4.2.1.17) fad-3 - Archaeoglobus fulgidus gi\|2649635, gi\|1... - gi\|2649635\|gb\|AAB90280.1\| enoyl-CoA hydratase (fad-3) [Archaeoglobus fulgidus DSM 4304], gi\|11498568...	2.0E-71	[5..268]	[4..252]
gi\|2392294, gi\|2... - gi\|3212683\|pdb\|2DUB\|F Chain F, Enoyl-Coa Hydratase Complexed With Octanoyl-Coa, gi\|3212682\|pdb\|2DUB\|...	5.0E-70	[3..269]	[5..257]

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Predicted Domain #1

Region A:
Residues: [1-271]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRVCYHIN GPFFIIKLID PKHLNSLTFE DFVYIALLLH KANDIDSVLF TVLQSSGKYF  60
   61 SSGGKFSAVN KLNDGDVTSE VEKVSKLVSA ISSPNIFVAN AFAIHKKVLV CCLNGPAIGL 120
  121 SASLVALCDI VYSQNDSVFL LFPFSNLGFV AEVGTSVTLT QKLGINSANE HMIFSTPVLF 180
  181 KELIGTIITK NYQLTNTETF NEKVLQDIKQ NLEGLYPKSV LGMKELLHSE MKQKLIKAQA 240
  241 METNGTLPFW ASGEPFKRFK QLQEGNRRHK L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	713.529817
Match:	1hnoA_
Description:	Dienoyl-CoA isomerase (delta3-delta2-enoyl-CoA isomerase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-hydroxyacyl-CoA dehydrogenase activity	4.25084649365698	bayes_pls_golite062009
CoA carboxylase activity	3.59076614105466	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	3.4980371783229	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.34692152434862	bayes_pls_golite062009
enoyl-CoA hydratase activity	3.27044058633674	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing C=C bonds	1.97586838275054	bayes_pls_golite062009
dodecenoyl-CoA delta-isomerase activity	1.80820904754223	bayes_pls_golite062009
catalytic activity	1.46154163027498	bayes_pls_golite062009
3-hydroxybutyryl-CoA epimerase activity	1.31614278936637	bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives	1.08284170936757	bayes_pls_golite062009
ligase activity	0.98581896521131	bayes_pls_golite062009
propionyl-CoA carboxylase activity	0.2998946244546	bayes_pls_golite062009
binding	0.222808057179506	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: