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View Structure Prediction Details

Protein: UFE1
Organism: Saccharomyces cerevisiae
Length: 346 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UFE1.

Description E-value Query
Range
Subject
Range
UFE1_YEAST - Syntaxin UFE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UFE1 PE=1 SV=2
UFE1 - t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that consti...
3.0E-56 [1..346] [1..346]
gi|3123708, gi|9... - gi|9625039|ref|NP_062506.1| syntaxin 1B1 [Mus musculus], gi|3123708|dbj|BAA25986.1| syntaxin1B [Mus ...
3.0E-45 [64..342] [28..278]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-45 [65..342] [1..250]
gi|149063192, gi... - gi|349317|gb|AAA03049.1| syntaxin 2', gi|149063192|gb|EDM13515.1| epimorphin, isoform CRA_b [Rattus ...
6.0E-44 [2..342] [1..280]
gi|18859443, gi|... - gi|7107406|gb|AAF36403.1|AF229154_1 syntaxin 1B [Danio rerio], gi|18859443|ref|NP_571598.1| syntaxin...
3.0E-43 [2..342] [1..278]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
5.0E-43 [2..342] [1..278]

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Predicted Domain #1
Region A:
Residues: [1-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSDLTPIFR KYVAVIDDAR NEQNGIDDHV ERKQEDFGNS NETCEMFRDS FIKECARLLK  60
   61 FLVELNKVIK QIEKNYLDDF NMSDAEKDEF DMECRLQIQQ YFKKFEFLEN YEMERHNLSL 120
  121 KRFQSKSHRW SKILSNKNDN TKHVIHPQDI ENGVYEFRLG VLRCLNLWIK YVSSKFTTIQ 180
  181 QERLILENKM NFNSTPMPTL S

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [263-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKVETINKTI LDIVNIQNEL SNHLTVQSQN INLMLNNQDD IELNIKKGNK ELRKAKRAAG  60
   61 RTAKMTTYGA IIMGVFILFL DYVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 1dn1B_
Description: Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SNAP receptor activity 3.50393203740159 bayes_pls_golite062009
protein transporter activity 2.305772311362 bayes_pls_golite062009
binding 2.18404492932496 bayes_pls_golite062009
protein binding 1.82422117934251 bayes_pls_golite062009
phosphatidic acid binding 1.79882292156155 bayes_pls_golite062009
transporter activity 1.74189664015129 bayes_pls_golite062009
substrate-specific transporter activity 1.49085442233849 bayes_pls_golite062009
transmembrane transporter activity 1.13101548288086 bayes_pls_golite062009
SNARE binding 0.71459772253941 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.643064875848901 bayes_pls_golite062009
ion transmembrane transporter activity 0.370484918396857 bayes_pls_golite062009
channel activity 0.0647076360772156 bayes_pls_golite062009
passive transmembrane transporter activity 0.0647076360772156 bayes_pls_golite062009
substrate-specific channel activity 0.0435980899803177 bayes_pls_golite062009
phospholipid binding 0.0172309833091902 bayes_pls_golite062009
cytoskeletal protein binding 0.00476738027966683 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [202-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNADDFSADA IDISVSQSAP VETVQDEVKH YEETISKLTQ EQLQVLETEH SELLNQKNEQ  60
   61 L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 1dn1B_
Description: Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle