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View Structure Prediction Details

Protein: RTS1
Organism: Saccharomyces cerevisiae
Length: 757 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RTS1.

Description E-value Query
Range
Subject
Range
ENSPTRT00000033615 - null
PPP2R5D - protein phosphatase 2, regulatory subunit B', delta
gi|167774187 - gi|167774187|gb|ABZ92528.1| protein phosphatase 2, regulatory subunit B', delta isoform [synthetic c...
0.0 [192..748] [18..543]
gi|148691584, gi... - gi|74180345|dbj|BAE32340.1| unnamed protein product [Mus musculus], gi|74141162|dbj|BAE35894.1| unna...
0.0 [192..748] [18..535]
2A5D_RABIT - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Oryctolagus cunic...
0.0 [192..748] [2..527]
gi|1168144 - gi|1168144|gb|AAB35312.1| SCS1 product [Saccharomyces cerevisiae]
0.0 [1..757] [1..757]

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Predicted Domain #1
Region A:
Residues: [1-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRGFKQRLI KKTTGSSSSS SSKKKDKEKE KEKSSTTSST SKKPASASSS SHGTTHSSAS  60
   61 STGSKSTTEK GKQSGSVPSQ GKHHSSSTSK TKTATTPSSS SSSSRSSSVS RSGSSSTKKT 120
  121 SSRKGQEQSK QSQQPSQSQK QGSSSSSAAI MNPTPVLTVT KDDKSTSGED HAHPTLLGAV 180
  181 SAVPSSPISN ASGTAVSSDV ENGNSNNNNM NINTSNTQDA NHASSQSIDI PRSSHSFERL 240
  241 PTPTKLNPDT DLELIKTPQR HSSSRFEPSR YTPLTKLPNF NE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 12.27
Match: 1ei3A
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [283-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSPEERIPLF IAKVDQCNTM FDFNDPSFDI QGKEIKRSTL DELIEFLVTN RFTYTNEMYA  60
   61 HVVNMFKINL FRPIPPPVNP VGDIYDPDED EP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.461 N/A N/A a.1.1 Globin-like
View Download 0.582 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.614 N/A N/A a.46.1 Methionine synthase domain
View Download 0.587 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.550 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.458 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.438 N/A N/A c.48.1 TK C-terminal domain-like
View Download 0.409 N/A N/A a.118.1 ARM repeat
View Download 0.375 N/A N/A a.47.2 t-snare proteins
View Download 0.374 N/A N/A d.58.17 Metal-binding domain
View Download 0.370 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.369 N/A N/A d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.369 N/A N/A d.68.6 DNA-binding protein Sso10b (AlbA)
View Download 0.360 N/A N/A a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.348 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.341 N/A N/A a.64.1 Saposin
View Download 0.319 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.302 N/A N/A d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.292 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.291 N/A N/A d.195.1 YopH tyrosine phosphatase N-terminal domain
View Download 0.290 N/A N/A a.2.3 Chaperone J-domain
View Download 0.269 N/A N/A a.3.1 Cytochrome c
View Download 0.263 N/A N/A c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.255 N/A N/A d.146.1 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
View Download 0.254 N/A N/A a.26.1 4-helical cytokines
View Download 0.251 N/A N/A a.156.1 S13-like H2TH domain
View Download 0.250 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.248 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.243 N/A N/A a.39.1 EF-hand
View Download 0.241 N/A N/A a.29.2 Bromodomain
View Download 0.237 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.235 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.233 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.229 N/A N/A a.3.1 Cytochrome c
View Download 0.227 N/A N/A d.57.1 DNA damage-inducible protein DinI
View Download 0.225 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.224 N/A N/A a.1.1 Globin-like
View Download 0.219 N/A N/A d.38.1 Thioesterase/thiol ester dehydrase-isomerase
View Download 0.217 N/A N/A i.1.1 Ribosome and ribosomal fragments
View Download 0.213 N/A N/A c.57.1 Molybdenum cofactor biosynthesis proteins
View Download 0.212 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.211 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.211 N/A N/A d.99.1 Ribosomal protein L9 C-domain
View Download 0.210 N/A N/A a.7.7 BAG domain
View Download 0.209 N/A N/A a.3.1 Cytochrome c
View Download 0.209 N/A N/A d.95.2 Homing endonucleases
View Download 0.209 N/A N/A a.24.4 Hemerythrin
View Download 0.204 N/A N/A d.78.1 RPB5-like RNA polymerase subunit
View Download 0.204 N/A N/A a.16.1 S15/NS1 RNA-binding domain
View Download 0.202 N/A N/A c.23.12 Formate/glycerate dehydrogenase catalytic domain-like

Predicted Domain #3
Region A:
Residues: [375-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNELAWPHMQ AVYEFFLRFV ESPDFNHQIA KQYIDQDFIL KLLELFDSED IRERDCLKTT  60
   61 LHRIYGKFLS LRSFIRRSMN NIFLQFIYET EKFNG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.75
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 7.41566231556356 bayes_pls_golite062009
phosphatase activity 6.2815295903206 bayes_pls_golite062009
protein serine/threonine phosphatase activity 6.23975872771765 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.04343158483355 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.13001603767079 bayes_pls_golite062009
protein phosphatase type 2A regulator activity 4.9046120881035 bayes_pls_golite062009
phosphatase regulator activity 2.6399267580941 bayes_pls_golite062009
binding 2.6374633159018 bayes_pls_golite062009
protein phosphatase regulator activity 2.60055057218296 bayes_pls_golite062009
hydrolase activity 1.97016752220053 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
enzyme regulator activity 0.698613639309592 bayes_pls_golite062009
kinase activity 0.60321289927821 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.590594379094637 bayes_pls_golite062009
nucleic acid binding 0.549076739943715 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.500341303844313 bayes_pls_golite062009
cytoskeletal protein binding 0.410980330975135 bayes_pls_golite062009
transferase activity 0.23030640245878 bayes_pls_golite062009
myosin phosphatase activity 0.0443887387331605 bayes_pls_golite062009
protein kinase activity 0.0343779350724151 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.0332743336452223 bayes_pls_golite062009
GTPase regulator activity 0.0268373969988844 bayes_pls_golite062009
guanyl ribonucleotide binding 0.00234756529236324 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [470-757]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAELLEILGS IINGFALPLK EEHKVFLVRI LIPLHKVRCL SLYHPQLAYC IVQFLEKDPL  60
   61 LTEEVVMGLL RYWPKINSTK EIMFLNEIED IFEVIEPLEF IKVEVPLFVQ LAKCISSPHF 120
  121 QVAEKVLSYW NNEYFLNLCI ENAEVILPII FPALYELTSQ LELDTANGED SISDPYMLVE 180
  181 QAINSGSWNR AIHAMAFKAL KIFLETNPVL YENCNALYLS SVKETQQRKV QREENWSKLE 240
  241 EYVKNLRINN DKDQYTIKNP ELRNSFNTAS ENNTLNEENE NDCDSEIQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.75
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle