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View Structure Prediction Details

Protein: FRE7
Organism: Saccharomyces cerevisiae
Length: 629 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE7.

Description E-value Query
Range
Subject
Range
FRE7 - Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.0 [1..629] [1..629]
RBOHB_SOLTU - Respiratory burst oxidase homolog protein B OS=Solanum tuberosum GN=RBOHB PE=1 SV=1
0.0 [60..609] [259..867]
RBOHD_ARATH - Respiratory burst oxidase homolog protein D OS=Arabidopsis thaliana GN=RBOHD PE=1 SV=1
0.0 [64..609] [315..921]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [64..609] [315..921]
gi|19715905 - gi|19715905|emb|CAC84140.1| NADPH oxidase [Nicotiana tabacum]
0.0 [60..609] [306..939]
gi|8131846, gi|8... - gi|8131890|gb|AAF73124.1|AF148534_1 whitefly-induced gp91-phox [Lycopersicon esculentum], gi|8131846...
0.0 [61..609] [304..938]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEERDLVLS NGIHCIADIH SELYARLKKE SQAATPWVYQ KQYGKFVTYF VAVIIFLSLI  60
   61 KKLAFMYYDS SEEFLPEK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [79-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNSPTTPSVF LARIMTKLVA FNRYICYRKF PTLIFSYLGI PTSVGTFLVV MATTLYTLLY  60
   61 CFVPHPFYRP CAGFGSPPLS VRAGIMAISL VPFVFSLSGK INVIGWLVGL SYEKINIYHQ 120
  121 WASILCLFFS WVHVIPFLRQ ARHEGGYERM HQRWKASDMW RSGVPPILFL NLLWLSSLPI 180
  181 ARRHFYEIFL QLHWILAVGF YISLFYHVYP ELNSHMYLVA TIVVWFAQLF YRLAVK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrogen ion transmembrane transporter activity 6.63598598376927 bayes_pls_golite062009
cation transmembrane transporter activity 5.19676916929792 bayes_pls_golite062009
ion transmembrane transporter activity 5.11036789264445 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.7380339483684 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 4.70584841199534 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 4.14430124170869 bayes_pls_golite062009
transporter activity 3.25025513931324 bayes_pls_golite062009
transmembrane transporter activity 3.15068691999889 bayes_pls_golite062009
substrate-specific transporter activity 2.88166365184739 bayes_pls_golite062009
binding 0.727993437899833 bayes_pls_golite062009
catalytic activity 0.573177797781864 bayes_pls_golite062009
protein binding 0.0725249103002593 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [315-413]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYLRPGRSFM ASTIANVSIV GEGCVELIVK DVEMAYSPGQ HIFVRTIDKG IISNHPFSIF  60
   61 PSAKYPGGIK MLIRAQKGFS KRLYESNDDM KKILIDGPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.69897
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.911136919465112 bayes_pls_golite062009
binding 0.671794680287713 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [414-553]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGIERDIRSF TNVYLICSGS GISTCLPFLQ KYGPILHKTN LEVITLDWVV RHREDISWIR  60
   61 DEMCTLSNNL RQLFLDGKIV VRIYVCSDST VPGIIKTFPQ TIDTASDQSD LAKREKDTEF 120
  121 GQDDTESNST FDKSNNEYKG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.69897
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [554-629]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LITIIPSKPD LNQVINDYQI GFRNCFICSG SDSLRYTVGN SVAVYRPRFF LTKMSKSAIY  60
   61 TARVLATSRK QMASTM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle