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View Structure Prediction Details

Protein: PRS5
Organism: Saccharomyces cerevisiae
Length: 496 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRS5.

Description E-value Query
Range		 Subject
Range
KPR5_YEAST - Ribose-phosphate pyrophosphokinase 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRS...
gi|190407284 - gi|190407284|gb|EDV10551.1| phosphoribosylpyrophosphate synthetase [Saccharomyces cerevisiae RM11-1a...
PRS5 - 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleot...
gi|151945573 - gi|151945573|gb|EDN63814.1| phosphoribosylpyrophosphate synthetase [Saccharomyces cerevisiae YJM789]
 0.0 [1..496] [1..496]
PRPS1_MOUSE - Ribose-phosphate pyrophosphokinase 1 OS=Mus musculus GN=Prps1 PE=1 SV=3
 0.0 [3..307] [1..304]
PRPS1 - phosphoribosyl pyrophosphate synthetase 1
gi|208967042, gi... - gi|208967042|dbj|BAG73535.1| phosphoribosyl pyrophosphate synthetase 1-like 1 [synthetic construct],...
ENSCJAT00000043257 - null
gi|114689771, gi... - gi|114689771|ref|XP_001144504.1| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes], gi|114...
PRPS1_PONAB - Ribose-phosphate pyrophosphokinase 1 OS=Pongo abelii GN=PRPS1 PE=2 SV=1
tr|M3WGN3|M3WGN3... - Phosphoribosyl pyrophosphate synthetase 1 OS=Felis catus GN=PRPS1 PE=3 SV=1
PRPS1_PONPY - Ribose-phosphate pyrophosphokinase I - Pongo pygmaeus (Orangutan)
gi|109131827 - gi|109131827|ref|XP_001095604.1| PREDICTED: similar to Ribose-phosphate pyrophosphokinase I (Phospho...
PRPS1_MOUSE - Ribose-phosphate pyrophosphokinase 1 OS=Mus musculus GN=Prps1 PE=1 SV=4
PRPS1_BOVIN - Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus GN=PRPS1 PE=2 SV=3
gi|74008042 - gi|74008042|ref|XP_850853.1| PREDICTED: similar to Ribose-phosphate pyrophosphokinase I (Phosphoribo...
PRPS1_RAT - Ribose-phosphate pyrophosphokinase 1 OS=Rattus norvegicus GN=Prps1 PE=1 SV=2
 0.0 [3..307] [1..304]
tr|G3I9Z3|G3I9Z3... - Ribose-phosphate pyrophosphokinase 2 OS=Cricetulus griseus GN=I79_020407 PE=3 SV=1
PRPS2_RAT - Ribose-phosphate pyrophosphokinase 2 OS=Rattus norvegicus GN=Prps2 PE=1 SV=3
 4.0E-99 [3..307] [1..304]
KPRS1_LACLA, KPR... - Ribose-phosphate pyrophosphokinase 1 OS=Lactococcus lactis subsp. lactis GN=prs1 PE=3 SV=1, (Q9CHB8)...
KPRS1_LACLA - Ribose-phosphate pyrophosphokinase 1 OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=prs1 PE=...
 8.0E-98 [1..317] [1..316]
KPRS2_SPIOL - Ribose-phosphate pyrophosphokinase 2, chloroplastic OS=Spinacia oleracea GN=PRS2 PE=2 SV=1
 1.0E-97 [2..307] [81..385]
gi|25288326 - pir||AF2389 ribose-phosphate pyrophosphokinase [imported] - Nostoc sp. (strain PCC 7120)
KPRS_NOSS1 - Ribose-phosphate pyrophosphokinase OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=prs PE=3 SV=1
 2.0E-97 [4..307] [20..320]

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Predicted Domain #1
Region A:
Residues: [1-141] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMSNIVVFG GDSHPELVTK ICENLDIHPS KVELGKFSNG ETNIALRESV REKDVYIIQS  60
   61 GCGQVNDTFM QLLILISACK SASASRVTAV MPYLCYSRQP DIPYTAKGAP IISKPKENYT 120
  121 FESHPGTPVS SSLMTQRPGA E

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [296-316] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADALELSFAL IHKERRSQLL K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 425.221849
Match: 1dkrA_
Description: Phosphoribosylpyrophosphate synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [142-295] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLKSLDSAI RSTINLENPQ PIRTPNSSAT ANNNFDIKKT LSFSRIPMIP GGKLQNTSNS  60
   61 TDAGELFNAQ NAGYKLWVVQ AGTLIAHLLS AAGADHVITM DLHDPQFPGF FDIPVDNLYC 120
  121 KPIAQNYIQH RIPDYQDAVI VSPDAGGAKR ATAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 425.221849
Match: 1dkrA_
Description: Phosphoribosylpyrophosphate synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transferase activity, transferring pentosyl groups 2.53679639481311 bayes_pls_golite062009
catalytic activity 2.30431811394775 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.13729318732922 bayes_pls_golite062009
transferase activity 2.03376808731027 bayes_pls_golite062009
amidophosphoribosyltransferase activity 1.6596316647688 bayes_pls_golite062009
ribose phosphate diphosphokinase activity 1.51875493459374 bayes_pls_golite062009
adenine phosphoribosyltransferase activity 0.74614037567654 bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity 0.625087274084001 bayes_pls_golite062009
diphosphotransferase activity 0.568107429488311 bayes_pls_golite062009
binding 0.496513332710902 bayes_pls_golite062009
uracil phosphoribosyltransferase activity 0.342418548886662 bayes_pls_golite062009
protein binding 0.182081394126725 bayes_pls_golite062009
orotate phosphoribosyltransferase activity 0.148898393751978 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [317-496] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPPDATLTSG GSLPVSPRPL VTTLVSSQNT TSSGATGVAA LEMKKTTSTS STSSQSSNSS  60
   61 KFVQTTMLVG DVRNKVCIIV DDLVDTSYTI TRAAKLLKDQ GSTKVYALIT HGVFSGDALE 120
  121 RIGQSSIDKL IISNTVPQDR TLQYLGKDRV DVIDVSCIIG EAIRRIHNGE SISMLFEHGW 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.221849
Match: 1ao0A_
Description: Glutamine PRPP amidotransferase, C-terminal domain; Glutamine PRPP amidotransferase, N-terminal domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle