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View Structure Prediction Details

Protein: SIL1
Organism: Saccharomyces cerevisiae
Length: 421 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIL1.

Description E-value Query
Range
Subject
Range
SIL1_YEAST - Nucleotide exchange factor SIL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIL1 PE=...
SIL1 - Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, require...
0.0 [1..421] [1..421]
SLS1_YARLI, SIL1... - (Q99158) SLS1 protein precursor, Nucleotide exchange factor SIL1 OS=Yarrowia lipolytica GN=SIL1 PE=1...
SIL1_YARLI - Nucleotide exchange factor SIL1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SIL1 PE=1 SV=2
0.0 [57..375] [35..392]
SIL1_MOUSE - Nucleotide exchange factor SIL1 OS=Mus musculus GN=Sil1 PE=1 SV=2
7.0E-90 [5..306] [26..356]
gi|157928988, gi... - gi|157928988|gb|ABW03779.1| SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae) [synthetic...
SIL1 - SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
2.0E-86 [1..306] [22..352]

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Predicted Domain #1
Region A:
Residues: [1-125]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRILPIILS ALSSKLVAST ILHSSIHSVP SGGEIISAED LKELEISGNS ICVDNRCYPK  60
   61 IFEPRHDWQP ILPGQELPGG LDIRINMDTG LKEAKLNDEK NVGDNGSHEL IVSSEDMKAS 120
  121 PGDYE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein transporter activity 2.17038865096656 bayes_pls_golite062009
protein binding 2.0097220759196 bayes_pls_golite062009
binding 1.83766472499136 bayes_pls_golite062009
transporter activity 1.12250209220616 bayes_pls_golite062009
substrate-specific transporter activity 0.68280791022469 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.3757449438966 bayes_pls_golite062009
nucleic acid binding 0.371883653230174 bayes_pls_golite062009
protein transmembrane transporter activity 0.347277736469816 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.298901699355651 bayes_pls_golite062009
signal sequence binding 0.279693431859311 bayes_pls_golite062009
nuclear localization sequence binding 0.241630311762028 bayes_pls_golite062009
hydrolase activity 0.0962597719675237 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [126-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSSDFKEMRN IIDSNPTLSS QDIARLEDSF DRIMEFAHDY KHGYKIITHE FALLANLSLN  60
   61 ENLPLTLREL STRVITSCLR NNPPVVEFIN ESFPNFKSKI MAALSN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.99
Match: 1ejlI
Description: Importin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [232-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNDSNHRSSN ILIKRYLSIL NELPVTSEDL PIYSTVVLQN VYERNNKDKQ LQIKVLELIS  60
   61 KILKADMYEN DDTNLILFKR NAENWSSNLQ EWA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.99
Match: 1ejlI
Description: Importin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [325-421]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEFQEMVQNK SIDELHTRTF FDTLYNLKKI FKSDITINKG FLNWLAQQCK ARQSNLDNGL  60
   61 QERDTEQDSF DKKLIDSRHL IFGNPMAHRI KNFRDEL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.99
Match: 1ejlI
Description: Importin alpha
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle