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View Structure Prediction Details

Protein: SIL1
Organism: Saccharomyces cerevisiae
Length: 421 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIL1.

Description E-value Query
Range
Subject
Range
SIL1_YEAST - Nucleotide exchange factor SIL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIL1 PE=...
SIL1 - Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, require...
0.0 [1..421] [1..421]
SLS1_YARLI, SIL1... - (Q99158) SLS1 protein precursor, Nucleotide exchange factor SIL1 OS=Yarrowia lipolytica GN=SIL1 PE=1...
SIL1_YARLI - Nucleotide exchange factor SIL1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SIL1 PE=1 SV=2
0.0 [57..375] [35..392]
SIL1_MOUSE - Nucleotide exchange factor SIL1 OS=Mus musculus GN=Sil1 PE=1 SV=2
7.0E-90 [5..306] [26..356]
gi|157928988, gi... - gi|157928988|gb|ABW03779.1| SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae) [synthetic...
SIL1 - SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
2.0E-86 [1..306] [22..352]

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Predicted Domain #1
Region A:
Residues: [1-125]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRILPIILS ALSSKLVAST ILHSSIHSVP SGGEIISAED LKELEISGNS ICVDNRCYPK  60
   61 IFEPRHDWQP ILPGQELPGG LDIRINMDTG LKEAKLNDEK NVGDNGSHEL IVSSEDMKAS 120
  121 PGDYE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein transporter activity 2.17038865096656 bayes_pls_golite062009
protein binding 2.0097220759196 bayes_pls_golite062009
binding 1.83766472499136 bayes_pls_golite062009
transporter activity 1.12250209220616 bayes_pls_golite062009
substrate-specific transporter activity 0.68280791022469 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.3757449438966 bayes_pls_golite062009
nucleic acid binding 0.371883653230174 bayes_pls_golite062009
protein transmembrane transporter activity 0.347277736469816 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.298901699355651 bayes_pls_golite062009
signal sequence binding 0.279693431859311 bayes_pls_golite062009
nuclear localization sequence binding 0.241630311762028 bayes_pls_golite062009
hydrolase activity 0.0962597719675237 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [126-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSSDFKEMRN IIDSNPTLSS QDIARLEDSF DRIMEFAHDY KHGYKIITHE FALLANLSLN  60
   61 ENLPLTLREL STRVITSCLR NNPPVVEFIN ESFPNFKSKI MAALSN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.99
Match: 1ejlI
Description: Importin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [232-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNDSNHRSSN ILIKRYLSIL NELPVTSEDL PIYSTVVLQN VYERNNKDKQ LQIKVLELIS  60
   61 KILKADMYEN DDTNLILFKR NAENWSSNLQ EWA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.99
Match: 1ejlI
Description: Importin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [325-421]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEFQEMVQNK SIDELHTRTF FDTLYNLKKI FKSDITINKG FLNWLAQQCK ARQSNLDNGL  60
   61 QERDTEQDSF DKKLIDSRHL IFGNPMAHRI KNFRDEL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.99
Match: 1ejlI
Description: Importin alpha
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle