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View Structure Prediction Details

Protein: ARE2
Organism: Saccharomyces cerevisiae
Length: 642 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARE2.

Description E-value Query
Range
Subject
Range
ARE2 - Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the...
ARE2_YEAST - Sterol O-acyltransferase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARE2 PE=1 SV=...
gi|190408982 - gi|190408982|gb|EDV12247.1| acyl-CoA cholesterol acyltransferase [Saccharomyces cerevisiae RM11-1a]
gi|151944547 - gi|151944547|gb|EDN62825.1| acyl-CoA cholesterol acyltransferase [Saccharomyces cerevisiae YJM789]
0.0 [1..642] [1..642]
gi|6625653 - gi|6625653|gb|AAF19345.1|AF129003_1 diacylglycerol acylCoA acyltransferase [Nicotiana tabacum]
0.0 [111..638] [33..518]
gi|7576941 - gi|7576941|gb|AAF64065.1|AF251794_1 putative diacylglycerol acyltransferase [Brassica napus]
0.0 [189..638] [87..487]
gi|10803053 - gi|10803053|gb|AAG23696.1|AF298815_1 diacylglycerol acyltransferase [Perilla frutescens]
0.0 [135..638] [69..520]
DGAT1_ARATH - Diacylglycerol O-acyltransferase 1 OS=Arabidopsis thaliana GN=DGAT1 PE=1 SV=2
0.0 [187..638] [104..506]
DGAT1_MOUSE - Diacylglycerol O-acyltransferase 1 OS=Mus musculus GN=Dgat1 PE=1 SV=1
0.0 [177..640] [62..484]
gi|18698659, gi|... - gi|18698659|gb|AAL78366.1|AF468650_1 acyl coenzyme A:diacylglycerol acyltransferase [Drosophila mela...
0.0 [151..639] [84..545]

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Predicted Domain #1
Region A:
Residues: [1-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKKKDLLEN EQFLRIQKLN AADAGKRQSI TVDDEGELYG LDTSGNSPAN EHTATTITQN  60
   61 HSVVASNGDV AFIPGTATEG NTEIVTEEVI ETDDNMFKTH VKTLSSKEKA RYRQGSSNFI 120
  121 SYFDDMSFEH RPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [134-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILDGSVNEPF KTKFVGPTLE KEIRRREKEL MAMRKNLHHR KSSPDAVDSV GKNDGAAPTT  60
   61 VPTAATSETV VTVETTIISS NFSGLYVAFW MAIAFGAVKA LIDYYYQHNG SFKDSEILKF 120
  121 MTTNLFTVAS VDLLMYLSTY FVVGIQYLCK WGVLKWGTTG WIFTSIYEFL FVIFYMYLTE 180
  181 NILKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.561 0.931 sterol metabolic process a.26.1 4-helical cytokines

Predicted Domain #3
Region A:
Residues: [319-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HWLSKIFLFL HSLVLLMKMH SFAFYNGYLW GIKEELQFSK SALAKYKDSI NDPKVIGALE  60
   61 KSCEFCSFEL SSQSLSDQT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.854 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3

Predicted Domain #4
Region A:
Residues: [398-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKFPNNISAK SFFWFTMFPT LIYQIEYPRT KEIRWSYVLE KICAIFGTIF LMMIDAQILM  60
   61 YPVAMRALAV RNSEWTGILD RLLKWVGLLV DIVPGFIVMY ILDFYLIWDA ILNCVAELTR 120
  121 FGDRYFYGDW WNCVSWADFS RIWNIPVHKF LLRHVYHSSM SSFKLNKSQA TLMTFFLSSV 180
  181 VHELAMYVIF KKLRFYLFFF QMLQMPLVAL TNTKFMRNRT IIGNVIFWLG ICMGPSVMCT 240
  241 LYLTF

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 130.823909
Match: PF01800
Description: No description for PF01800 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [488-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIVPGFIVMY ILDFYLIWDA ILNCVAELTR FGDRYFYGDW WNCVSWADFS RIWNIPVHKF  60
   61 LLRHVYHSSM SSFKLNKSQA TLMTFFLSSV VHELAMYVIF 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [588-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKLRFYLFFF QMLQMPLVAL TNTKFMRNRT IIGNVIFWLG ICMGPSVMCT LYLTF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle