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View Structure Prediction Details

Protein: ARE2
Organism: Saccharomyces cerevisiae
Length: 642 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARE2.

Description E-value Query
Range
Subject
Range
ARE2 - Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the...
ARE2_YEAST - Sterol O-acyltransferase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARE2 PE=1 SV=...
gi|190408982 - gi|190408982|gb|EDV12247.1| acyl-CoA cholesterol acyltransferase [Saccharomyces cerevisiae RM11-1a]
gi|151944547 - gi|151944547|gb|EDN62825.1| acyl-CoA cholesterol acyltransferase [Saccharomyces cerevisiae YJM789]
0.0 [1..642] [1..642]
gi|6625653 - gi|6625653|gb|AAF19345.1|AF129003_1 diacylglycerol acylCoA acyltransferase [Nicotiana tabacum]
0.0 [111..638] [33..518]
gi|7576941 - gi|7576941|gb|AAF64065.1|AF251794_1 putative diacylglycerol acyltransferase [Brassica napus]
0.0 [189..638] [87..487]
gi|10803053 - gi|10803053|gb|AAG23696.1|AF298815_1 diacylglycerol acyltransferase [Perilla frutescens]
0.0 [135..638] [69..520]
DGAT1_ARATH - Diacylglycerol O-acyltransferase 1 OS=Arabidopsis thaliana GN=DGAT1 PE=1 SV=2
0.0 [187..638] [104..506]
DGAT1_MOUSE - Diacylglycerol O-acyltransferase 1 OS=Mus musculus GN=Dgat1 PE=1 SV=1
0.0 [177..640] [62..484]
gi|18698659, gi|... - gi|18698659|gb|AAL78366.1|AF468650_1 acyl coenzyme A:diacylglycerol acyltransferase [Drosophila mela...
0.0 [151..639] [84..545]

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Predicted Domain #1
Region A:
Residues: [1-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKKKDLLEN EQFLRIQKLN AADAGKRQSI TVDDEGELYG LDTSGNSPAN EHTATTITQN  60
   61 HSVVASNGDV AFIPGTATEG NTEIVTEEVI ETDDNMFKTH VKTLSSKEKA RYRQGSSNFI 120
  121 SYFDDMSFEH RPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.221 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.270 c.47.1 Thioredoxin-like
View Download 0.415 a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.375 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.415 a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.375 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.277 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.277 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.270 c.47.1 Thioredoxin-like
View Download 0.221 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.201 a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #2
Region A:
Residues: [134-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILDGSVNEPF KTKFVGPTLE KEIRRREKEL MAMRKNLHHR KSSPDAVDSV GKNDGAAPTT  60
   61 VPTAATSETV VTVETTIISS NFSGLYVAFW MAIAFGAVKA LIDYYYQHNG SFKDSEILKF 120
  121 MTTNLFTVAS VDLLMYLSTY FVVGIQYLCK WGVLKWGTTG WIFTSIYEFL FVIFYMYLTE 180
  181 NILKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.561 0.931 sterol metabolic process a.26.1 4-helical cytokines
View Download 0.800 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.800 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.790 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.561 N/A N/A a.26.1 4-helical cytokines
View Download 0.500 N/A N/A a.26.1 4-helical cytokines
View Download 0.456 N/A N/A a.26.1 4-helical cytokines
View Download 0.456 N/A N/A a.26.1 4-helical cytokines
View Download 0.418 N/A N/A a.47.2 t-snare proteins
View Download 0.412 N/A N/A d.67.3 Ribosome recycling factor, RRF
View Download 0.389 N/A N/A a.24.1 Apolipoprotein
View Download 0.388 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.368 N/A N/A a.172.1 Helical scaffold and wing domains of SecA
View Download 0.366 N/A N/A f.25.1 Cytochrome c oxidase subunit III-like
View Download 0.357 N/A N/A a.172.1 Helical scaffold and wing domains of SecA
View Download 0.354 N/A N/A d.67.3 Ribosome recycling factor, RRF
View Download 0.347 N/A N/A f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.344 N/A N/A a.47.2 t-snare proteins
View Download 0.343 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.338 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.333 N/A N/A d.173.1 Methionine synthase activation domain-like
View Download 0.309 N/A N/A a.47.2 t-snare proteins
View Download 0.305 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.296 N/A N/A a.25.1 Ferritin-like
View Download 0.294 N/A N/A a.172.1 Helical scaffold and wing domains of SecA
View Download 0.293 N/A N/A a.25.1 Ferritin-like
View Download 0.292 N/A N/A a.7.4 Smac/diablo
View Download 0.283 N/A N/A d.67.3 Ribosome recycling factor, RRF
View Download 0.280 N/A N/A a.26.1 4-helical cytokines
View Download 0.275 N/A N/A a.7.1 Spectrin repeat
View Download 0.273 N/A N/A f.25.1 Cytochrome c oxidase subunit III-like
View Download 0.273 N/A N/A c.1.10 Aldolase
View Download 0.272 N/A N/A f.21.1 Transmembrane di-heme cytochromes
View Download 0.266 N/A N/A f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.251 N/A N/A c.55.3 Ribonuclease H-like
View Download 0.250 N/A N/A a.47.1 STAT
View Download 0.250 N/A N/A a.118.1 ARM repeat
View Download 0.243 N/A N/A f.31.1 Photosystem I reaction center subunit XI, PsaL
View Download 0.242 N/A N/A a.1.1 Globin-like
View Download 0.239 N/A N/A d.67.3 Ribosome recycling factor, RRF
View Download 0.239 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.231 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.231 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.225 N/A N/A f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.225 N/A N/A d.67.3 Ribosome recycling factor, RRF
View Download 0.221 N/A N/A a.63.1 Apolipophorin-III
View Download 0.218 N/A N/A d.67.3 Ribosome recycling factor, RRF
View Download 0.217 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.214 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.213 N/A N/A a.47.2 t-snare proteins
View Download 0.212 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.210 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.209 N/A N/A a.25.1 Ferritin-like
View Download 0.209 N/A N/A a.47.1 STAT
View Download 0.207 N/A N/A a.87.1 DBL homology domain (DH-domain)
View Download 0.206 N/A N/A a.7.4 Smac/diablo
View Download 0.206 N/A N/A a.172.1 Helical scaffold and wing domains of SecA
View Download 0.204 N/A N/A d.67.3 Ribosome recycling factor, RRF
View Download 0.200 N/A N/A c.55.3 Ribonuclease H-like

Predicted Domain #3
Region A:
Residues: [319-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HWLSKIFLFL HSLVLLMKMH SFAFYNGYLW GIKEELQFSK SALAKYKDSI NDPKVIGALE  60
   61 KSCEFCSFEL SSQSLSDQT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.854 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.782 a.47.2 t-snare proteins
View Download 0.769 a.47.2 t-snare proteins
View Download 0.735 a.7.6 Ribosomal protein S20
View Download 0.730 a.16.1 S15/NS1 RNA-binding domain

Predicted Domain #4
Region A:
Residues: [398-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKFPNNISAK SFFWFTMFPT LIYQIEYPRT KEIRWSYVLE KICAIFGTIF LMMIDAQILM  60
   61 YPVAMRALAV RNSEWTGILD RLLKWVGLLV DIVPGFIVMY ILDFYLIWDA ILNCVAELTR 120
  121 FGDRYFYGDW WNCVSWADFS RIWNIPVHKF LLRHVYHSSM SSFKLNKSQA TLMTFFLSSV 180
  181 VHELAMYVIF KKLRFYLFFF QMLQMPLVAL TNTKFMRNRT IIGNVIFWLG ICMGPSVMCT 240
  241 LYLTF

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 130.823909
Match: PF01800
Description: No description for PF01800 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [488-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DIVPGFIVMY ILDFYLIWDA ILNCVAELTR FGDRYFYGDW WNCVSWADFS RIWNIPVHKF  60
   61 LLRHVYHSSM SSFKLNKSQA TLMTFFLSSV VHELAMYVIF 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [588-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKLRFYLFFF QMLQMPLVAL TNTKFMRNRT IIGNVIFWLG ICMGPSVMCT LYLTF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle