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View Structure Prediction Details

Protein: URE2
Organism: Saccharomyces cerevisiae
Length: 354 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for URE2.

Description E-value Query
Range		 Subject
Range
URE2_SACPA - Protein URE2 OS=Saccharomyces paradoxus GN=URE2 PE=3 SV=1
URE2_SACDO - Protein URE2 OS=Saccharomyces douglasii GN=URE2 PE=3 SV=1
 2.0E-91 [1..354] [1..359]
gi|151944317 - gi|151944317|gb|EDN62595.1| prion [Saccharomyces cerevisiae YJM789]
URE2_YEAST - Transcriptional regulator URE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URE2 PE=1...
gi|190409200 - gi|190409200|gb|EDV12465.1| protein URE2 [Saccharomyces cerevisiae RM11-1a]
gi|207341870 - gi|207341870|gb|EDZ69810.1| YNL229Cp-like protein [Saccharomyces cerevisiae AWRI1631]
URE2 - Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcripti...
 3.0E-89 [1..354] [1..354]
URE2_KLULA - Protein URE2 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1...
URE2_KLULA - Protein URE2 OS=Kluyveromyces lactis GN=URE2 PE=3 SV=1
 5.0E-78 [6..354] [11..389]
URE2_CANAL - Protein URE2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URE2 PE=3 SV=1
URE2_CANAL - Protein URE2 OS=Candida albicans GN=URE2 PE=3 SV=1
 1.0E-58 [16..354] [8..344]
gi|25287116, gi|... - gi|4127352|emb|CAA09190.1| glutathione transferase [Alopecurus myosuroides], pir||T52085 glutathione...
 3.0E-55 [111..349] [1..209]
GSTF_HYOMU - Glutathione S-transferase OS=Hyoscyamus muticus PE=1 SV=1
 2.0E-54 [113..351] [2..208]

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Predicted Domain #1
Region A:
Residues: [1-91] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNNNGNQVS NLSNALRQVN IGNRNSNTTT DQSNINFEFS TGVNNNNNNN SSSNNNNVQN  60
   61 NNSGRNGSQN NDNENNIKNT LEQHRQQQQA F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.428 0.100 response to aluminum ion d.1.1 Microbial ribonucleases
View Download 0.253 0.039 response to aluminum ion d.66.1 Alpha-L RNA-binding motif
View Download 0.283 0.022 response to aluminum ion a.20.1 PGBD-like
View Download 0.352 0.007 response to aluminum ion a.150.1 Anti-sigma factor AsiA
View Download 0.268 0.005 response to aluminum ion d.58.36 Sulfite reductase, domains 1 and 3
View Download 0.204 N/A N/A d.95.2 Homing endonucleases

Predicted Domain #2
Region A:
Residues: [92-199] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDMSHVEYSR ITKFFQEQPL EGYTLFSHRS APNGFKVAIV LSELGFHYNT IFLDFNLGEH  60
   61 RAPEFVSVNP NARVPALIDH GMDNLSIWES GAILLHLVNK YYKETGNP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [347-354] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIKALRGE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1625.39794
Match: 1g6wA_
Description: Yeast prion protein ure2p, nitrogen regulation fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.66884588063322 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
glutathione binding 3.12157603958172 bayes_pls_golite062009
selenium binding 2.6356580403901 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
glutathione transferase activity 1.85683051472829 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 1.8187537496904 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
transcription regulator activity 1.27179487791083 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
phospholipid-hydroperoxide glutathione peroxidase activity 0.874146425427531 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
transferase activity 0.245320538630117 bayes_pls_golite062009
protein binding 0.134341907247724 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [200-346] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLWSDDLADQ SQINAWLFFQ TSGHAPMIGQ ALHFRYFHSQ KIASAVERYT DEVRRVYGVV  60
   61 EMALAERREA LVMELDTENA AAYSAGTTPM SQSRFFDYPV WLVGDKLTIA DLAFVPWNNV 120
  121 VDRIGINIKI EFPEVYKWTK HMMRRPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1625.39794
Match: 1g6wA_
Description: Yeast prion protein ure2p, nitrogen regulation fragment
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle